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Chemical Compound Review

Otrivine     2-[(2,6-dimethyl-4-tert- butyl...

Synonyms: Novorin, Otriven, Otrivin, Otrix, stas, ...
 
 
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Analytical, diagnostic and therapeutic context of Otrivin

  • They were divided into the test group which received shea butter, the control group which was treated with xylometazoline and the 'placebo' group which received white petroleum jelly B.P. 4 The results showed that nasal congestion was relieved more satisfactorily in the test group than in the other two groups [24].
  • Determination of xylometazoline in plasma and urine by gas chromatography using a fused-silica capillary column and an electron-capture detector [25].
  • Fifty-four healthy children (28 male), median age 9.5 years (range 5.9-16.0), performed full forced respiratory maneuvers through: 1) the mouth, 2) the nose, 3) the nose after application of an external stent (Breathe Right (BR) strip), and 4) the nose following instillation of xylometazoline [26].
  • There was no correlation between the percentage change in airflow (rhinomanometry) and the percentage change in blood flux (laser Doppler) following xylometazoline [27].
  • The assumption was made that the degree of swelling could be related to the degree of decongestive effect of xylometazoline, and measured by acoustic rhinometry [28].

References

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  3. Inhibition of nitric oxide synthase by nasal decongestants. Westerveld, G.J., Voss, H.P., van der Hee, R.M., de Haan-Koelewijn, G.J., den Hartog, G.J., Scheeren, R.A., Bast, A. Eur. Respir. J. (2000) [Pubmed]
  4. Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study. Otten, F.W., Grote, J.J. Laryngoscope (1990) [Pubmed]
  5. Adenosine-induced increase in myocardial adenine nucleotides without adenosine-induced systemic hypotension. Isselhard, W., Hamaji, M., Mäurer, W., Erkens, H., Welter, H. Basic Res. Cardiol. (1985) [Pubmed]
  6. Anti-oxidant actions of oxymethazoline and xylomethazoline. Westerveld, G.J., Scheeren, R.A., Dekker, I., Griffioen, D.H., Voss, H.P., Bast, A. Eur. J. Pharmacol. (1995) [Pubmed]
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  9. No effect of a nasal decongestant on eustachian tube function in children with ventilation tubes. van Heerbeek, N., Ingels, K.J., Zielhuis, G.A. Laryngoscope (2002) [Pubmed]
  10. Hypoxia depresses nitric oxide output in the human nasal airways. Haight, J.S., Qian, W., Daya, H., Chalmers, P., Zamel, N. Laryngoscope (2000) [Pubmed]
  11. Nasal vasoconstrictor activity of a novel PGE2 analog. Jackson, R.T., Birnbaum, J.E. Prostaglandins (1981) [Pubmed]
  12. Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation. Ertl, G., Fuchs, M. Basic Res. Cardiol. (1980) [Pubmed]
  13. Comparison of decongestive capacity of xylometazoline and pseudoephedrine with rhinomanometry and MRI. Caenen, M., Hamels, K., Deron, P., Clement, P. Rhinology. (2005) [Pubmed]
  14. Function and structure of the nasal mucosa after 6 weeks' use of nose-drops. Petruson, B., Hansson, H.A. Acta Otolaryngol. (1982) [Pubmed]
  15. The effects of nasal drops and their additives on human nasal mucociliary clearance. van de Donk, H.J., van den Heuvel, A.G., Zuidema, J., Merkus, F.W. Rhinology. (1982) [Pubmed]
  16. Correlation between the sensitivity of the ciliary beat frequency of human adenoid tissue and chicken embryo tracheas for some drugs. van de Donk, H.J., Zuidema, J., Merkus, F.W. Rhinology. (1982) [Pubmed]
  17. The effect of Xylometazoline on the mucosa of human maxillary sinus. Falck, B., Svanholm, H., Aust, R. Rhinology. (1990) [Pubmed]
  18. Treatment of perennial allergic rhinitis by sodium cromoglycate plus 0.025 per cent xylometazoline (a double-blind study). Fradis, M., Podoshin, L., Gertner, R. The Journal of laryngology and otology. (1987) [Pubmed]
  19. Evaluation of protective and therapeutic effects of dexpanthenol on nasal decongestants and preservatives: results of cytotoxic studies in vitro. Klöcker, N., Rudolph, P., Verse, T. American journal of rhinology. (2004) [Pubmed]
  20. Nasal responses to local unilateral stimuli in man. Haight, J.S., Cole, P. Rhinology. (1983) [Pubmed]
  21. Central action of narcotic analgesics. Part IV. Noradrenergic influences on the activity of analgesics in rats. Malec, D., Grabowska, E., Langwiński, R. Polish journal of pharmacology and pharmacy. (1978) [Pubmed]
  22. Coma in a neonate following single intranasal dose of xylometazoline. Dunn, C., Gauthier, M., Gaudreault, P. Eur. J. Pediatr. (1993) [Pubmed]
  23. Decongestant effects of nasal xylometazoline and mometasone furoate in persistent allergic rhinitis. Barnes, M.L., Biallosterski, B.T., Gray, R.D., Fardon, T.C., Lipworth, B.J. Rhinology. (2005) [Pubmed]
  24. Preliminary studies on nasal decongestant activity from the seed of the shea butter tree, Butyrospermum parkii. Tella, A. British journal of clinical pharmacology. (1979) [Pubmed]
  25. Determination of xylometazoline in plasma and urine by gas chromatography using a fused-silica capillary column and an electron-capture detector. Sioufi, A., Leroux, F., Dubois, J.P. J. Chromatogr. (1989) [Pubmed]
  26. Nasal flow limitation in children. Pickering, D.N., Beardsmore, C.S. Pediatr. Pulmonol. (1999) [Pubmed]
  27. A comparison of the effects of xylometazoline on nasal airflow, and on blood flux as measured by laser Doppler flowmetry. Wight, R.G., Cochrane, T. Acta Otolaryngol. (1989) [Pubmed]
  28. Nasal congestion in relation to low air exchange rate in schools. Evaluation by acoustic rhinometry. Wålinder, R., Norbäck, D., Wieslander, G., Smedje, G., Erwall, C. Acta Otolaryngol. (1997) [Pubmed]
 
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