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Gene Review

LAMA1  -  laminin, alpha 1

Homo sapiens

Synonyms: LAMA, Laminin A chain, Laminin subunit alpha-1, Laminin-1 subunit alpha, Laminin-3 subunit alpha, ...
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Disease relevance of LAMA1


High impact information on LAMA1


Chemical compound and disease context of LAMA1

  • For each of 3 separate evaluations, 6 fasted llamas (Lama glama) were sedated with xylazine (1.1 mg/kg of body weight, IV) and then 15 minutes later were given normal saline solution (5.0 ml, IV; control values), doxapram (2.2 mg/kg, IV), or 4-amino-pyridine (0.3 mg/kg, IV) and yohimbine (0.125 mg/kg, IV) [10].

Biological context of LAMA1


Anatomical context of LAMA1


Associations of LAMA1 with chemical compounds

  • Sulfatide-binding domain of the laminin A chain [20].
  • Interactions between the proteasome inhibitor bortezomib and histone deacetylase inhibitors (HDIs) have been examined in Bcr/Abl+ human leukemia cells (K562 and LAMA 84) [21].
  • Similar events were observed in other Bcr/Abl(+) cells (i.e., LAMA 84), and in cells exposed to STI571 in combination with the HDI sodium butyrate [22].
  • The sequence similarity corresponds to the G domain of laminin A chain, which binds heparin and type IV collagen [23].
  • STI571 and SAHA also interacted synergistically to induce apoptosis in STI571-resistant K562 and LAMA 84 cells that display increased Bcr/Abl protein expression [22].

Physical interactions of LAMA1

  • Amino acid sequencing of the approximately 55 kDa fragment identified a conformationally dependent Abeta-binding site within laminin localized to the globular repeats on the laminin A chain [24].

Enzymatic interactions of LAMA1

  • We have previously demonstrated that a synthetic peptide derived from amino acids 2091-2108 of the laminin A chain (designated LamA2091-2108) can significantly enhance t-PA-catalyzed Pg activation [14].

Other interactions of LAMA1


Analytical, diagnostic and therapeutic context of LAMA1


  1. Keratosis pilaris/ulerythema ophryogenes and 18p deletion: is it possible that the LAMA1 gene is involved? Zouboulis, C.C., Stratakis, C.A., Gollnick, H.P., Orfanos, C.E. J. Med. Genet. (2001) [Pubmed]
  2. Primary structure of the human laminin A chain. Limited expression in human tissues. Nissinen, M., Vuolteenaho, R., Boot-Handford, R., Kallunki, P., Tryggvason, K. Biochem. J. (1991) [Pubmed]
  3. Modulation of plasminogen activation and type IV collagenase activity by a synthetic peptide derived from the laminin A chain. Stack, S., Gray, R.D., Pizzo, S.V. Biochemistry (1991) [Pubmed]
  4. Isolation of shiga toxin-producing Escherichia coli from a South American camelid (Lama guanicoe) with diarrhea. Mercado, E.C., Rodríguez, S.M., Elizondo, A.M., Marcoppido, G., Parreño, V. J. Clin. Microbiol. (2004) [Pubmed]
  5. Erythrocyte dyscrasia, anemia, and hypothyroidism in chronically underweight llamas. Smith, B.B., Reed, P.J., Pearson, E.G., Long, P., Lassen, E.D., Watrous, B.J., Lovelady, S., Sims, D.E., Snyder, S.P. J. Am. Vet. Med. Assoc. (1991) [Pubmed]
  6. Neuroscience meeting draws fire over Dalai Lama lecture. Cyranoski, D. Nat. Med. (2005) [Pubmed]
  7. Killing of laminin receptor-positive human lung cancers by tumor infiltrating lymphocytes bearing gammadelta(+) t-cell receptors. Ferrarini, M., Heltai, S., Pupa, S.M., Mernard,, S., Zocchi, R. J. Natl. Cancer Inst. (1996) [Pubmed]
  8. Reciprocal expression of laminin A-chain isoforms along the crypt-villus axis in the human small intestine. Beaulieu, J.F., Vachon, P.H. Gastroenterology (1994) [Pubmed]
  9. A synthetic peptide derived from the carboxy terminus of the laminin A chain represents a binding site for the alpha 3 beta 1 integrin. Gehlsen, K.R., Sriramarao, P., Furcht, L.T., Skubitz, A.P. J. Cell Biol. (1992) [Pubmed]
  10. Reversal of xylazine-induced sedation in llamas, using doxapram or 4-aminopyridine and yohimbine. Riebold, T.W., Kaneps, A.J., Schmotzer, W.B. J. Am. Vet. Med. Assoc. (1986) [Pubmed]
  11. Morphological classification of nuchal skin in human fetuses with trisomy 21, 18, and 13 at 12-18 weeks and in a trisomy 16 mouse. von Kaisenberg, C.S., Krenn, V., Ludwig, M., Nicolaides, K.H., Brand-Saberi, B. Anat. Embryol. (1998) [Pubmed]
  12. The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. Moser, T.L., Enghild, J.J., Pizzo, S.V., Stack, M.S. J. Biol. Chem. (1993) [Pubmed]
  13. Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. Olsen, D., Nagayoshi, T., Fazio, M., Peltonen, J., Jaakkola, S., Sanborn, D., Sasaki, T., Kuivaniemi, H., Chu, M.L., Deutzmann, R. Lab. Invest. (1989) [Pubmed]
  14. The effect of substituted laminin A chain-derived peptides on the conformation and activation kinetics of plasminogen. Stack, M.S., Pizzo, S.V. Arch. Biochem. Biophys. (1994) [Pubmed]
  15. Appearance and distribution of laminin A chain isoforms and integrin alpha 2, alpha 3, alpha 6, beta 1, and beta 4 subunits in the developing human small intestinal mucosa. Perreault, N., Vachon, P.H., Beaulieu, J.F. Anat. Rec. (1995) [Pubmed]
  16. Tissue-specific expression in the salivary glands of transgenic mice. Mikkelsen, T.R., Brandt, J., Larsen, H.J., Larsen, B.B., Poulsen, K., Ingerslev, J., Din, N., Hjorth, J.P. Nucleic Acids Res. (1992) [Pubmed]
  17. Basal lamina formation by epithelial cell lines correlates with laminin A chain synthesis and secretion. Ecay, T.W., Valentich, J.D. Exp. Cell Res. (1992) [Pubmed]
  18. A synthetic peptide deduced from the sequence in the cross-region of laminin A chain mediates neurite outgrowth, cell attachment and heparin binding. Tashiro, K., Nagata, I., Yamashita, N., Okazaki, K., Ogomori, K., Tashiro, N., Anai, M. Biochem. J. (1994) [Pubmed]
  19. Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo. Grant, D.S., Kinsella, J.L., Fridman, R., Auerbach, R., Piasecki, B.A., Yamada, Y., Zain, M., Kleinman, H.K. J. Cell. Physiol. (1992) [Pubmed]
  20. Sulfatide-binding domain of the laminin A chain. Taraboletti, G., Rao, C.N., Krutzsch, H.C., Liotta, L.A., Roberts, D.D. J. Biol. Chem. (1990) [Pubmed]
  21. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Yu, C., Rahmani, M., Conrad, D., Subler, M., Dent, P., Grant, S. Blood (2003) [Pubmed]
  22. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells. Yu, C., Rahmani, M., Almenara, J., Subler, M., Krystal, G., Conrad, D., Varticovski, L., Dent, P., Grant, S. Cancer Res. (2003) [Pubmed]
  23. Sex hormone-binding globulin, androgen-binding protein, and vitamin K-dependent protein S are homologous to laminin A, merosin, and Drosophila crumbs protein. Joseph, D.R., Baker, M.E. FASEB J. (1992) [Pubmed]
  24. Laminin inhibition of beta-amyloid protein (Abeta) fibrillogenesis and identification of an Abeta binding site localized to the globular domain repeats on the laminin a chain. Castillo, G.M., Lukito, W., Peskind, E., Raskind, M., Kirschner, D.A., Yee, A.G., Snow, A.D. J. Neurosci. Res. (2000) [Pubmed]
  25. A new nomenclature for the laminins. Burgeson, R.E., Chiquet, M., Deutzmann, R., Ekblom, P., Engel, J., Kleinman, H., Martin, G.R., Meneguzzi, G., Paulsson, M., Sanes, J. Matrix Biol. (1994) [Pubmed]
  26. Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain. Richards, A.J., al-Imara, L., Carter, N.P., Lloyd, J.C., Leversha, M.A., Pope, F.M. Genomics (1994) [Pubmed]
  27. Proteolytic digestion of non-collagenous basement membrane proteins by the hemorrhagic metalloproteinase Ht-e from Crotalus atrox venom. Baramova, E.N., Shannon, J.D., Fox, J.W., Bjarnason, J.B. Biomed. Biochim. Acta (1991) [Pubmed]
  28. Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor. Murdoch, A.D., Dodge, G.R., Cohen, I., Tuan, R.S., Iozzo, R.V. J. Biol. Chem. (1992) [Pubmed]
  29. Purification and characterization of matrix metalloproteinase 9 from U937 monocytic leukaemia and HT1080 fibrosarcoma cells. Morodomi, T., Ogata, Y., Sasaguri, Y., Morimatsu, M., Nagase, H. Biochem. J. (1992) [Pubmed]
  30. Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. Nagayoshi, T., Mattei, M.G., Passage, E., Knowlton, R., Chu, M.L., Uitto, J. Genomics (1989) [Pubmed]
  31. Proteoglycans of basement membranes. Timpl, R. EXS. (1994) [Pubmed]
  32. Molecular cloning of the cDNA encoding human laminin A chain. Haaparanta, T., Uitto, J., Ruoslahti, E., Engvall, E. Matrix (1991) [Pubmed]
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