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Chemical Compound Review

Rubidium-86     rubidium

Synonyms: AC1O3RN9, 86Rb, 14932-53-7, UNII-EHJ48551WX, Rubidium, isotope of mass 86
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Disease relevance of rubidium


High impact information on rubidium

  • This study examined the effect of moderate ethanol intake on systolic blood pressure, platelet cytosolic free calcium, aortic calcium, and rubidium-86 uptake in Wistar-Kyoto rats [3].
  • Several analogues have been compared with cromakalim (1) for their effects on potassium ion efflux in the rabbit mesenteric artery using rubidium-86 as a marker [4].
  • Large concentrations of potassium were used to stimulate the release of rubidium-86 from preloaded cortical synaptosomes, so that the pharmacological sensitivity of this efflux could be examined [5].
  • In T3-treated rats, rubidium-86 (86Rb) uptake (measured as a marker of Na/K ATPase activity) in ex vivo hypothalamic tissue increased (P<0.01) while the content of ATP in the ventral hypothalamus declined following T3 treatment (P<0.01) [6].
  • The stimulatory effect on human erythrocyte rubidium-86 uptake by anti-cardiac-glycoside antibodies [7].

Biological context of rubidium


Anatomical context of rubidium


Associations of rubidium with other chemical compounds

  • The ability of each compound to enhance rubidium-86 efflux is approximately parallelled by its blood pressure lowering activity, and thus these analogues, like compound (1), belong to the series of drugs which have been classified as potassium-channel activators [4].
  • The effect of ouabain on myocardial nutritional circulation (rubidium-86 extraction) and regional myocardial blood flow (radioactive microspheres) was studied in the isolated supported canine heart preparation perfused at a constant coronary blood flow [15].
  • Chromium-51 ethylenediaminetetraacetic acid ((51)Cr-EDTA) and rubidium-86 chloride ((86)RbCl) were deposited intraluminally to determine the extent of the increase in intestinal permeability and ion channel disruption [16].
  • To examine how cell culture in hypokalemic media would affect the Na,K pump, we determined ouabain-sensitive rubidium-86 uptake in the presence of monensin plus foetal calf serum in cells incubated for 24 hours in low and normal potassium containing culture media [9].
  • The effect of noradrenaline on myocardial sodium-pump activity has been studied, using a direct measure of active ion transport via the pump; namely, the ouabain-sensitive uptake of the radioisotope and potassium analogue rubidium-86 into guinea pig ventricular tissue slices [17].

Analytical, diagnostic and therapeutic context of rubidium


  1. Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution. Herrera, V.L., Ruiz-Opazo, N. Science (1990) [Pubmed]
  2. Rubidium-86 uptake by red blood cells of breast cancer patients. Telfer, N., Lee, Y.T., Merrill, Q., Bauer, F.K. Journal of surgical oncology. (1981) [Pubmed]
  3. Platelet-free calcium and vascular calcium uptake in ethanol-induced hypertensive rats. Vasdev, S., Sampson, C.A., Prabhakaran, V.M. Hypertension (1991) [Pubmed]
  4. Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans. Ashwood, V.A., Cassidy, F., Coldwell, M.C., Evans, J.M., Hamilton, T.C., Howlett, D.R., Smith, D.M., Stemp, G. J. Med. Chem. (1990) [Pubmed]
  5. Efflux of rubidium in rat cortical synaptosomes is blocked by sigma and dextromethorphan binding site ligands. Fletcher, E.J., Drew, C., Lodge, D., O'Shaughnessy, C.T. Neuropharmacology (1989) [Pubmed]
  6. Effects of thyroid hormone on food intake, hypothalamic Na/K ATPase activity and ATP content. Luo, L., MacLean, D.B. Brain Res. (2003) [Pubmed]
  7. The stimulatory effect on human erythrocyte rubidium-86 uptake by anti-cardiac-glycoside antibodies. Balzan, S., Montali, U., Pieraccini, L., Di Bartolo, V., Pegoraro, S., Revoltella, R., Ghione, S. The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR). (1995) [Pubmed]
  8. Influence of surface charge and transmembrane potential on rubidium-86 efflux of human red blood cells. Bernhardt, I., Donath, E., Glaser, R. J. Membr. Biol. (1984) [Pubmed]
  9. Effects of alterations in cell phenotype and hypokalemia on sodium-potassium pump activity in rabbit vascular smooth muscle. Little, P.J., Bobik, A. Clinical and experimental hypertension. Part A, Theory and practice. (1985) [Pubmed]
  10. Cellular injury from sustained vs. acute hydrogen peroxide exposure in cultured human corneal endothelium and human lens epithelium. Polansky, J.R., Fauss, D.J., Hydorn, T., Bloom, E. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc. (1990) [Pubmed]
  11. Rubidium-86 uptake and energy metabolism in suspended human erythrocytes monitored by microdialysis. Ljungberg, I., Waldenström, A., Ronquist, G. J. Int. Med. Res. (2004) [Pubmed]
  12. The effect of cholesterol on glycerophosphono- and glycerophosphinocholines. Permeability measurements in lipid vesicles. Bittman, R., Clejan, S., Fugler, L., Rosenthal, A.F. Biochim. Biophys. Acta (1986) [Pubmed]
  13. Effect of sexual cycle on red cell membrane permeability as revealed by influx of Rubidium-86 and adenosinetriphosphatase in female rats. Sarkar, S.R., Singh, L.R., Banerji, R., Chaudhuri, B.N. Indian J. Physiol. Pharmacol. (1983) [Pubmed]
  14. Intracellular pH influences the resting membrane potential of isolated rat hepatocytes. Bear, C.E., Davison, J.S., Shaffer, E.A. Biochim. Biophys. Acta (1988) [Pubmed]
  15. The effect of ouabain on nutritional circulation and regional myocardial blood flow. Gross, G.J., Warltier, D.C., Hardman, H.F., Somani, P. Am. Heart J. (1977) [Pubmed]
  16. Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury. Abel, E., Ekman, T., Warnhammar, E., Hultborn, R., Jennische, E., Lange, S. Dig. Dis. Sci. (2005) [Pubmed]
  17. Effects of noradrenaline on the sodium pump of guinea pig ventricle. Wanless, R.B., Noble, M.I., Drake-Holland, A.J. Advances in myocardiology. (1985) [Pubmed]
  18. Na,K-ATPase response to osmotic stress in primary dog lens epithelial cells. Old, S.E., Carper, D.A., Hohman, T.C. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  19. Evaluation of methods for estimating renal medullary blood flow. Hansell, P. Renal physiology and biochemistry. (1992) [Pubmed]
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