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Chemical Compound Review

BW-A4C     N-hydroxy-N-[(E)-3-(3- phenoxyphenyl)prop-2...

Synonyms: Bwa-4C, BWA4C, BW4C, CHEMBL314360, Bwa 4C, ...
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Disease relevance of Bwa 4C


High impact information on Bwa 4C

  • Mast cell- and lymphocyte-induced eosinophil survival were completely reversed by SB 201146, SKF 104353, BW A4C, and MK 886 [5].
  • Furthermore, the release-enhancing effect of McNeil A 343 (10 microM) on noradrenaline release was also not altered by the 5-lipoxygenase inhibitor, BW A4C [6].
  • For comparison, the effects of a 5-lipoxygenase inhibitor, BW A4C (1 x 10(-9)-10(-5) M), and a corticosteroid, budesonide (1 x 10(-10)-10(-5) M) were also examined [7].
  • Likewise, when BW A4C was administered to guinea pigs intravenously (3 mg/kg), we observed a rapid and marked (approximately 90%) reduction in whole blood LTB4 production which returned to control (pre-drug values) by 5 hr [8].
  • Indomethacin (3 microM) and the 5-lipoxygenase inhibitor, BW A4C (1 microM) were without effect on basal or evoked [3H]NE release, suggesting that endogenously formed arachidonic acid metabolites have no significant modulatory role in this in vitro system [9].

Biological context of Bwa 4C


Anatomical context of Bwa 4C

  • 7. The accumulation of leucocytes in sponge exudates was reduced dose-dependently by BW A4C (ED50 = 54 mg kg-1) and BW A797C (ED50 = 16.7 mg kg-1) [1].
  • The effects of BW A4C, a selective arachidonate 5-lipoxygenase (5-LO) inhibitor, on the progression of myocardial tissue injury were examined in anaesthetised, open-chest beagle dogs subjected to 90-min occlusion of the left anterior descending coronary artery (LAD) followed by 120-min reperfusion [12].

Associations of Bwa 4C with other chemical compounds


Gene context of Bwa 4C


Analytical, diagnostic and therapeutic context of Bwa 4C

  • Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion [12].


  1. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on acute inflammatory responses. Higgs, G.A., Follenfant, R.L., Garland, L.G. Br. J. Pharmacol. (1988) [Pubmed]
  2. Possible involvement of eicosanoids in alpha-naphthylthiourea-induced pulmonary oedema and alteration of angiotensin-converting enzyme activity. Ercan, Z.S., Eren, S., Zengil, H., Türker, R.K. Pharmacology (1993) [Pubmed]
  3. Bradykinin induces eosinophil accumulation in the rat pleural cavity. Pasquale, C.P., Martins, M.A., Bozza, P.T., Silva, P.M., Faria Neto, H.C., Pires, A.L., Cordeiro, R.S. Int. Arch. Allergy Appl. Immunol. (1991) [Pubmed]
  4. Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart. Gök, S., Ulker, S., Hüseyinov, A., Evinç, A. Gen. Pharmacol. (1997) [Pubmed]
  5. Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals. Lee, E., Robertson, T., Smith, J., Kilfeather, S. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  6. Evidence that M1 muscarinic receptors enhance noradrenaline release in mouse atria by activating protein kinase C. Costa, M., Barrington, M., Majewski, H. Br. J. Pharmacol. (1993) [Pubmed]
  7. The effects of beta 2-adrenoceptor agonists and a corticosteroid, budesonide, on the secretion of inflammatory mediators from monocytes. Linden, M. Br. J. Pharmacol. (1992) [Pubmed]
  8. Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. Spaethe, S.M., Snyder, D.W., Pechous, P.A., Clarke, T., VanAlstyne, E.L. Biochem. Pharmacol. (1992) [Pubmed]
  9. Prejunctional inhibitory effects of prostanoids on sympathetic neurotransmission in the rabbit iris-ciliary body. Ohia, S.E., Jumblatt, J.E. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  10. Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo. Tateson, J.E., Randall, R.W., Reynolds, C.H., Jackson, W.P., Bhattacherjee, P., Salmon, J.A., Garland, L.G. Br. J. Pharmacol. (1988) [Pubmed]
  11. A comparison of the anti-inflammatory activity of selective 5-lipoxygenase inhibitors with dexamethasone and colchicine in a model of zymosan induced inflammation in the rat knee joint and peritoneal cavity. Griffiths, R.J., Li, S.W., Wood, B.E., Blackham, A. Agents Actions (1991) [Pubmed]
  12. Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion. Maxwell, M.P., Marston, C., Hadley, M.R., Salmon, J.A., Garland, L.G. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  13. Interleukin-1 beta and interleukin-6 stimulate neurohypophysial hormone release in vitro. Yasin, S.A., Costa, A., Forsling, M.L., Grossman, A. J. Neuroendocrinol. (1994) [Pubmed]
  14. BW A4C and other hydroxamic acids are potent inhibitors of linoleic acid 8R-dioxygenase of the fungus Gaeumannomyces graminis. Brodowsky, I.D., Hamberg, M., Oliw, E.H. Eur. J. Pharmacol. (1994) [Pubmed]
  15. Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Payne, A.N., Jackson, W.P., Salmon, J.A., Nicholls, A., Yeadon, M., Garland, L.G. Agents Actions Suppl. (1991) [Pubmed]
  16. Participation of interleukin-5 and interleukin-8 in the eosinophil migration induced by a large volume of saline. Oliveira, S.H., Faccioli, L.H., Cunha, F.Q., Ferreira, S.H. Int. Arch. Allergy Immunol. (1996) [Pubmed]
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