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Chemical Compound Review

BW-755C     1-[3- (trifluoromethyl)phenyl]- 4,5...

Synonyms: CHEMBL274642, AG-G-48466, SureCN2573191, CHEBI:103667, AC1L2IRR, ...
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Disease relevance of BW-755C

  • To determine whether invading leukocytes mediate these responses, acute inflammatory cell influx was suppressed either by inducing leukopenia with nitrogen mustard or by administration of BW-755C, a mixed cyclooxygenase-lipoxygenase inhibitor [1].
  • The protein inhibited edema when rats were pretreated with agents that depleted mast-cell amines, kininogen, or polymorphonuclear leukocytes prior to initiation of the carrageenin edema but had no inhibitory action when rats were pretreated with the dual cyclooxygenase/lipoxygenase inhibitor BW 755C [2].
  • BW755C significantly reduced myocardial infarct size compared with that in control animals, as measured by infarct/risk areas by histochemical staining (39 +/- 5% vs. 63 +/- 7%, p < 0.05) [3].
  • In 9 control and 10 study pigs pretreated with intravenous BW755C (10 mg/kg body weight) 30 min before coronary occlusion, ischemia was induced by a 50-min occlusion of the mid-left anterior descending coronary artery, followed by 3 h of reperfusion [3].
  • Using mesentery, the effects were tested of BW755C, a lipoxygenase inhibitor, and of SM9064, a LTB4 receptor antagonist, upon the increase in leucocyte adherence observed during hypoxia [4].

High impact information on BW-755C


Chemical compound and disease context of BW-755C


Biological context of BW-755C


Anatomical context of BW-755C


Associations of BW-755C with other chemical compounds

  • In ischemic gerbils treated with 15 and 100 mg/kg AA-861 and 30 mg/kg BW-755C, the average neuronal densities were 12 +/- 1, 13 +/- 1, and 14 +/- 2, respectively [23].
  • In ischemic gerbils with vehicle administration, the average neuronal densities were 13 +/- 2, 14 +/- 2, 13 +/- 2, and 13 +/- 1 for piroxicam, flurbiprofen, AA-861, and BW-755C, respectively [23].
  • In addition to histamine-H1 blockers, lipoxygenase inhibitors (nordihydroguaiarectic acid and BW 755C) and leukotriene blockers (FPL 55712 and LY 171883) are also potent inhibitors of CBE-induced RGC secretion [24].
  • Phenidone and BW 755C are also to be cyclooxygenase inhibitors [25].
  • Moreover, the inhibitory effect of 8-OH-DPAT on the carbachol response was blocked by 10 microM quinacrine (a phospholipase A2 inhibitor) but not by BW 755C (100 microM), a cyclooxygenase and lipoxygenase inhibitor [26].

Gene context of BW-755C


Analytical, diagnostic and therapeutic context of BW-755C

  • In animals treated with BW755C, renal allograft blood flow was maintained over the postoperative 5-day period at levels comparable to blood flow to the native kidneys [32].
  • BW755C (10 mg/kg i.v., n = 10) significantly reduced this mural platelet deposition by more than 50% to 25.4 +/- 5.3 x 10(6)/cm2 (P < .05) and decreased 111In neutrophil deposition from 240.6 +/- 30.4 x 10(3)/cm2 in the control group to 114.4 +/- 20.4 x 10(3)/cm2 (P < .005) in the treated group [17].
  • These results indicate that the dual lipoxygenase/cyclooxygenase inhibitor BW755C prevents the acute thrombotic and vasomotor responses related to arterial injury by angioplasty, predominantly through inhibition of neutrophil function [17].
  • Thirty minutes before occlusion, animals randomly received BW755C, 3 mg/kg (n = 7), or 10 mg/kg (n = 8), or saline (n = 16) by intravenous infusion [33].
  • Atropine and leukotriene inhibitors (LY171883 and BW755C) were not found to have a significant protective effect on WDE-induced constriction [34].


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  2. Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. Cirino, G., Peers, S.H., Flower, R.J., Browning, J.L., Pepinsky, R.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  3. Limitation of myocardial infarct size in pigs with a dual lipoxygenase-cyclooxygenase blocking agent by inhibition of neutrophil activity without reduction of neutrophil migration. Amsterdam, E.A., Pan, H.L., Rendig, S.V., Symons, J.D., Fletcher, M.P., Longhurst, J.C. J. Am. Coll. Cardiol. (1993) [Pubmed]
  4. Effect of acute systemic hypoxia on vascular permeability and leucocyte adherence in the anaesthetised rat. Mian, R., Marshall, J.M. Cardiovasc. Res. (1993) [Pubmed]
  5. Inhibition of tissue damage by the arachidonate lipoxygenase inhibitor BW755C. Higgs, G.A., Mugridge, K.G., Moncada, S., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  6. Vanadate activates platelets by enhancing arachidonic acid release. McNicol, A., Robertson, C., Gerrard, J.M. Blood (1993) [Pubmed]
  7. Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis. Snyder, D.S., Desforges, J.F. Blood (1986) [Pubmed]
  8. Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor-mediated rat hepatocyte proliferation. Adachi, T., Nakashima, S., Saji, S., Nakamura, T., Nozawa, Y. Hepatology (1995) [Pubmed]
  9. Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors. Denis, D., Falgueyret, J.P., Riendeau, D., Abramovitz, M. J. Biol. Chem. (1991) [Pubmed]
  10. Relationships between tumour necrosis factor, eicosanoids and platelet-activating factor as mediators of endotoxin-induced shock in mice. Myers, A.K., Robey, J.W., Price, R.M. Br. J. Pharmacol. (1990) [Pubmed]
  11. Reduction of apparent indicators of liver cirrhosis in rats by the arachidonate lipoxygenase inhibitor BW755C. Mourelle, M., Amezcua, J.L., Pérez-Alvarez, V. Eur. J. Pharmacol. (1987) [Pubmed]
  12. Effects of cyclo- and lipoxygenase inhibitors on hypoxic vasoconstriction in isolated ferret lungs. Gottlieb, J.E., McGeady, M., Adkinson, N.F., Sylvester, J.T. J. Appl. Physiol. (1988) [Pubmed]
  13. Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice. Wang, J.P., Hsu, M.F., Raung, S.L., Kuo, S.C. Naunyn Schmiedebergs Arch. Pharmacol. (1994) [Pubmed]
  14. Do inhibitors of lipoxygenase and cyclooxygenase block neonatal hypoxic pulmonary vasoconstriction? Cassin, S., Gause, G., Davis, T., ter Riet, M., Baker, R. J. Appl. Physiol. (1989) [Pubmed]
  15. Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes. Lennartz, M.R., Brown, E.J. J. Immunol. (1991) [Pubmed]
  16. Aggregation and/or oxygenated products of arachidonic acid are not required for collagen-induced deacylation of phosphatidylcholine in human platelets. Piché, L.A., Mahadevappa, V.G. Biochem. J. (1989) [Pubmed]
  17. BW755C, a dual lipoxygenase/cyclooxygenase inhibitor, reduces mural platelet and neutrophil deposition and vasoconstriction after angioplasty injury in pigs. Provost, P., Merhi, Y. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  18. Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. Boukili, M.A., Bureau, M., Lagente, V., Lefort, J., Lellouch-Tubiana, A., Malanchère, E., Vargaftig, B.B. Br. J. Pharmacol. (1986) [Pubmed]
  19. Arachidonic acid metabolism in the murine eosinophil. III. Effect of nonsteroid anti-inflammatory drugs on lymphokine-directed eosinophil migration in vivo. Rand, T.H., Clanton, J.A., Colley, D.G. J. Immunol. (1983) [Pubmed]
  20. Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation. Seaman, W.E. J. Immunol. (1983) [Pubmed]
  21. Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid. Seaman, W.E., Woodcock, J. J. Allergy Clin. Immunol. (1984) [Pubmed]
  22. Human neutrophil adhesion to bovine aortic endothelium. Evidence for endothelial lipoxygenase activity. Damtew, B., Goldsmith, G., Tserng, K.Y., Spagnuolo, P.J. J. Leukoc. Biol. (1993) [Pubmed]
  23. Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus. Nakagomi, T., Sasaki, T., Kirino, T., Tamura, A., Noguchi, M., Saito, I., Takakura, K. Stroke (1989) [Pubmed]
  24. The effect of cotton bract extract on respiratory glycoconjugate secretion from human airways in vitro. Marom, Z., Schachter, E.N., Goswami, S., Witek, T., Buck, M. J. Allergy Clin. Immunol. (1989) [Pubmed]
  25. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway. Nakadate, T., Yamamoto, S., Ishii, M., Kato, R. Carcinogenesis (1982) [Pubmed]
  26. Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. Claustre, Y., Benavides, J., Scatton, B. J. Neurochem. (1991) [Pubmed]
  27. Effects of inhibitors of inflammatory mediators and cytokines on eosinophil and neutrophil accumulation induced by Mycobacterium bovis bacillus Calmette-Guérin in mouse pleurisy. Menezes-de-Lima-Júnior, O., Werneck-Barroso, E., Cordeiro, R.S., Henriques, M.G. J. Leukoc. Biol. (1997) [Pubmed]
  28. Endothelin modulation of neuroeffector transmission in smooth muscle. Wiklund, N.P., Wiklund, C.U., Cederqvist, B., Ohlén, A., Hedqvist, P., Gustafsson, L.E. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  29. Enkephalinase inhibitor potentiates mammalian tachykinin-induced contraction in ferret trachea. Sekizawa, K., Tamaoki, J., Graf, P.D., Basbaum, C.B., Borson, D.B., Nadel, J.A. J. Pharmacol. Exp. Ther. (1987) [Pubmed]
  30. Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. Vedelago, H.R., Mahadevappa, V.G. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  31. Beta-endorphin and adrenocorticotropin release from rat adenohypophysis in vitro: evidence for local modulation by arachidonic acid metabolites of the cyclooxygenase and lipoxygenase pathway. Vlaskovska, M., Knepel, W. Neuroendocrinology (1984) [Pubmed]
  32. Eicosanoid synthesis inhibition and renal allograft function during acute rejection. Mangino, M.J., Jendrisak, M.D., Brunt, E., Anderson, C.B. Transplantation (1988) [Pubmed]
  33. Effect of BW755C in an occlusion-reperfusion model of ischemic myocardial injury. Jolly, S.R., Lucchesi, B.R. Am. Heart J. (1983) [Pubmed]
  34. Pharmacologic characterization of wool dust extract in isolated guinea pig trachea. Schachter, E.N., Zuskin, E., Buck, M.G., Maayani, S., Marom, Z., Goswami, S., Rienzi, N. Environmental research. (1995) [Pubmed]
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