The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Aldrithiol-2     2-pyridin-2- yldisulfanylpyridine

Synonyms: Aldrithiol 2, PubChem12536, CHEMBL118678, D5767_SIGMA, ANW-13694, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pyridine disulfide analog


High impact information on Pyridine disulfide analog


Biological context of Pyridine disulfide analog

  • The rate of reaction of ALDH with 2,2'-dithiodipyridine is only slightly reduced by DES, suggesting that the site at which thiol modifiers react and the DES binding site are different [11].

Anatomical context of Pyridine disulfide analog

  • 2,2'-Dithiodipyridine (2,2'-DTDP), a reactive disulphide that mobilizes Ca2+ from ryanodine-sensitive Ca2+ stores in muscle, induced a biphasic increase in cytoplasmic free Ca2+ concentration ([Ca2+]i) in pancreatic beta-cells loaded with fura 2 [10].
  • Human lymphoid cell cultures were treated with 2,2'-dithiodipyridine, a thiol reacting agent which produces SS bridges inside the living cells [12].
  • In 2001, we showed in vitro that dendritic cells (DCs) of HIV-infected patients loaded with autologous HIV chemically inactivated by aldrithiol-2 were capable of raising an HIV-specific cellular immune response powerful enough to allow the destruction of autologous HIV- infected CD4 T cells [13].

Associations of Pyridine disulfide analog with other chemical compounds


Gene context of Pyridine disulfide analog


Analytical, diagnostic and therapeutic context of Pyridine disulfide analog


  1. Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo. Fitzgerald, W., Sylwester, A.W., Grivel, J.C., Lifson, J.D., Margolis, L.B. J. Virol. (2004) [Pubmed]
  2. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. Rossio, J.L., Esser, M.T., Suryanarayana, K., Schneider, D.K., Bess, J.W., Vasquez, G.M., Wiltrout, T.A., Chertova, E., Grimes, M.K., Sattentau, Q., Arthur, L.O., Henderson, L.E., Lifson, J.D. J. Virol. (1998) [Pubmed]
  3. CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Choudhary, S.K., Walker, R.M., Powell, D.M., Planelles, V., Walsh, C., Camerini, D. Virology (2006) [Pubmed]
  4. Presentation of exogenous whole inactivated simian immunodeficiency virus by mature dendritic cells induces CD4+ and CD8+ T-cell responses. Frank, I., Santos, J.J., Mehlhop, E., Villamide-Herrera, L., Santisteban, C., Gettie, A., Ignatius, R., Lifson, J.D., Pope, M. J. Acquir. Immune Defic. Syndr. (2003) [Pubmed]
  5. Chemical inactivation of retroviral infectivity by targeting nucleocapsid protein zinc fingers: a candidate SIV vaccine. Arthur, L.O., Bess, J.W., Chertova, E.N., Rossio, J.L., Esser, M.T., Benveniste, R.E., Henderson, L.E., Lifson, J.D. AIDS Res. Hum. Retroviruses (1998) [Pubmed]
  6. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Rassa, J.C., Meyers, J.L., Zhang, Y., Kudaravalli, R., Ross, S.R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. Functional consequences of sulfhydryl modification in the pore-forming subunits of cardiovascular Ca2+ and Na+ channels. Chiamvimonvat, N., O'Rourke, B., Kamp, T.J., Kallen, R.G., Hofmann, F., Flockerzi, V., Marban, E. Circ. Res. (1995) [Pubmed]
  8. Divergent consequences arise from metallothionein overexpression in astrocytes: zinc buffering and oxidant-induced zinc release. Malaiyandi, L.M., Dineley, K.E., Reynolds, I.J. Glia (2004) [Pubmed]
  9. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. Aizenman, E., Stout, A.K., Hartnett, K.A., Dineley, K.E., McLaughlin, B., Reynolds, I.J. J. Neurochem. (2000) [Pubmed]
  10. Thiol oxidation by 2,2'-dithiodipyridine causes a reversible increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. Role for inositol 1,4,5-trisphosphate-sensitive Ca2+ stores. Islam, M.S., Kindmark, H., Larsson, O., Berggren, P.O. Biochem. J. (1997) [Pubmed]
  11. Effects of diethylstilbestrol, 2,2'-dithiodipyridine, and chloral hydrate on the esterase activity of sheep liver cytoplasmic aldehyde dehydrogenase. Kitson, T.M. Biochemistry (1986) [Pubmed]
  12. The effect of SH-SS transition in the structural organization of mitotic chromosomes. Kosztolányi, G., Bühler, E.M. Hum. Genet. (1978) [Pubmed]
  13. A dendritic cell-based vaccine for treating HIV infection: background and preliminary results. Andrieu, J.M., Lu, W. J. Intern. Med. (2007) [Pubmed]
  14. Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin. Nicklin, M.J., Barrett, A.J. Biochem. J. (1984) [Pubmed]
  15. Reaction of hemerythrin with disulfides. Harrington, P.C., Wilkins, R.G. Biochemistry (1985) [Pubmed]
  16. Radiation effects on erythrocyte membrane structure studied by the intrinsic fluorescence. Yonei, S., Todo, T., Kato, M. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1979) [Pubmed]
  17. Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin L in vitro and in vivo. Hashida, S., Towatari, T., Kominami, E., Katunuma, N. J. Biochem. (1980) [Pubmed]
  18. Thiol-disulphide interchange in tubulin: kinetics and the effect on polymerization. Britto, P.J., Knipling, L., McPhie, P., Wolff, J. Biochem. J. (2005) [Pubmed]
  19. The activation of aldehyde dehydrogenase by diethylstilboestrol and 2,2'-dithiodipyridine. Kitson, T.M. Biochem. J. (1982) [Pubmed]
  20. The effect of some amine oxides and disulphide compounds on the activity of acetylcholinesterase. Dawson, R.M. Biochem. J. (1975) [Pubmed]
  21. Characterization of the covalent chromatography of thymidylate synthase on thiopropyl-Sepharose 6B. Bradshaw, T.P., Dunlap, R.B. Biochim. Biophys. Acta (1993) [Pubmed]
WikiGenes - Universities