Disease relevance of Cefminox

• In vitro activities of cefminox against anaerobic bacteria compared with those of nine other compounds [1].
• Cefminox was especially active against Bacteroides fragilis (MIC90, 2.0 microg/ml), Bacteroides thetaiotaomicron (MIC90, 4.0 microg/ml), fusobacteria (MIC90, 1.0 microg/ml), peptostreptococci (MIC90, 2.0 microg/ml), and clostridia, including Clostridium difficile (MIC90, 2.0 microg/ml) [1].
• Effect of inoculum size on bacteriolytic activity of cefminox and four other beta-lactam antibiotics against Escherichia coli [2].
• Synthesis of cefminox by cell-free extracts of Streptomyces clavuligerus [3].
• The formation of cefminox was detected both by a biological assay with Proteus vulgaris GN 76/C-1 and by high performance liquid chromatography [3].

High impact information on Cefminox

• When selecting antibiotics for prophylactic use against infections in the retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy, on the basis of drug transfer, flomoxef, cefminox, cefbuperazone, ceftazidime, and cefpimizole were considered to be the drugs of first choice at a dose of 1 g [4].
• Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers [5].
• Comparative susceptibility of cefminox and cefoxitin to beta-lactamases of Bacteroides spp [6].
• Efficacy of cefminox compared with amoxicillin/clavulanic acid as a single dose for the prevention of intra-abdominal sepsis in mice intraperitoneally infected with different strains of Escherichia coli and one strain of Bacteroides fragilis [7].
• A postmarketing surveillance of cefminox sodium (Meicelin, CMNX) for intravenous injection was conducted for about 4 years from August 1987 through June 1991, and 13,431 patients were followed up to evaluate the safety of the drug [8].

Chemical compound and disease context of Cefminox

• Pretreatment with piperacillin for 1 h followed by combined treatment with cefminox showed a profound enhancement of the bacteriolytic activity against 12 out of 20 strains, especially against Serratia, Enterobacter and Pseudomonas species [9].
• Comparative in vitro and in vivo activity of cefminox (MT-141), cefotaxime and cefoperazone against gram-negative bacteria [10].

Associations of Cefminox with other chemical compounds

• Bacteriolytic combination effect of cefminox and piperacillin evaluated by turbidimetry [9].
• The bacteriolytic combination effect of cefminox (a potent bactericidal cephamycin) and piperacillin (a broad spectrum ureidopenicillin) was investigated using turbidimetry and expressed as a measure of the combination effect by the relative ratios of bacteriolytic area under the growth curves [9].

Analytical, diagnostic and therapeutic context of Cefminox

• Cefminox displayed an earlier onset and a higher rate of bactericidal action than the other cephamycins against the test organisms, although the minimum inhibitory concentrations of cefminox were similar to or higher than those of the other drugs [11].

References