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Chemical Compound Review

CEFBUPERAZONE     (6R,7R)-7-[[(2S,3R)-2-[(4- ethyl-2,3-dioxo...

Synonyms: Cefbuperazona, Cefbuperzaone, Cerbuperazone, Cefbuperazonum, SureCN1649528, ...
 
 
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Disease relevance of CEFBUPERAZONE

 

Psychiatry related information on CEFBUPERAZONE

 

High impact information on CEFBUPERAZONE

  • By DNA blot hybridization analysis we show that the alkylation-sensitive E. coli mutant BS23 [Sedgwick, B. & Lindahl, T. (1982) J. Mol. Biol. 154, 169-175] is a deletion mutant lacking the entire ada-alkB operon [7].
  • Similar translation-assembly experiments with Drosophila poly(A)+ mRNA reveal that a Mr 26,000 protein identified previously in Drosophila U1 RNP [Wieben, E. D. & Pederson, T. (1982) Mol. Cell. Biol. 2, 914-920] also binds to U1 RNA in vitro [8].
  • This sequence shows high homology with Tylorrhynchus chain I (Suzuki, T., Takagi, T., and Gotoh, T. (1982) Biochem. Biophys. Acta 708, 253-258) and Lumbricus chain AIII (Garlick, R. L., and Riggs, A. F. (1982) J. Biol. Chem. 257, 9005-9015) [9].
  • The conformation of the dephosphorylated 10 S monomer is highly unusual in that the 1500 A long myosin tail is folded into approximately equal thirds (Onishi, H., and Wakabayashi, T. (1982) J. Biochem. (Tokyo) 92, 871-879; Trybus, K. M., Huiatt, T. W., and Lowey, S. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 6151-6155) [10].
  • The E. coli L-factor enhances transcription pausing at this site (Farnham, P. J., Greenblatt, J., and Platt, T. (1982) Cell 29, 945-951); presumably it does so by facilitating recognition of the RNA hairpin by polymerase [11].
 

Chemical compound and disease context of CEFBUPERAZONE

 

Biological context of CEFBUPERAZONE

 

Anatomical context of CEFBUPERAZONE

  • A subcellular particulate fraction from normal neutrophils that was enriched in NADPH-dependent O-.2-generating activity (Gabig, T. G., Schervish, E. W., and Santinga, J. T. (1982) J. Biol. Chem. 257, 4114-4119) has been further characterized [17].
  • Although mice did not die when treated with an L. monocytogenes-resistant broad-spectrum cephalosporin, sodium cefbuperazone, before and during infection, the number of L. monocytogenes bacteria increased in the feces [18].
  • The maximum concentrations after administration of a 1-g dose in the exudate of the pelvic retroperitoneal space were 37.9 micrograms/ml with cefminox, 30.3 micrograms/ml with cefpimizole, 21.6 micrograms/ml with flomoxef, 21.5 micrograms/ml with ceftazidime, and 17.6 micrograms/ml with cefbuperazone, which were relatively high [19].
  • In thirteen patients with normal liver function, the mean concentrations of cefbuperazone in hepatic bile, gall bladder bile and gallbladder tissue 30 min after injection were 1134.8 +/- 36.8 (mean +/- S.E.M.) mg/l, 6.6 +/- 3.0 mg/l and 26.1 +/- 7.6 mg/l, respectively [20].
  • (Jonas, A.J., Smith, M.L. and Schneider, J.A. (1982) J. Biol. Chem. 257, 13185-13188), that the lysosomal proton-translocating ATPase (Okhuma, S., Moriyama, Y. and Takano, T. (1982) Proc. Natl. Acad. Sci. USA 79, 2758-2762) is not impaired in cystinotic fibroblasts [21].
 

Associations of CEFBUPERAZONE with other chemical compounds

 

Gene context of CEFBUPERAZONE

  • Its properties were the same as those of intact lysosomes reported previously (Ohkuma, S., Moriyama, Y., & Takano, T. (1982) Proc. Natl. Acad. Sci. U.S. 79, 2758-2762; Moriyama, Y., Takano, T., & Ohkuma, S. (1982) J. Biochem. 92, 1333-1336) [23].
  • Hansen [Hansen M. T. (1982) Mutat. Res. 106, 209-216], after a study of the photobinding of psoralen to nucleic acids in the acrA mutant, also suggested that DNA environment was modified in acrA cells [24].
  • In vitro activity of cefbuperazone compared with that of other new beta-lactam agents against anaerobic gram-negative bacilli and contribution of beta-lactamase to resistance [25].
  • The present observation together with our previous finding of sequence homology between barley trypsin inhibitor and wheat alpha-amylase inhibitor (Odani, S., Koide, T., & Ono, T. (1982) FEBS Lett. 141, 279-282) suggest an unusual evolutionary relationship between cereal enzyme inhibitors and animal proteinase inhibitors of the Kazal type [26].
  • Previously, we (Onishi, H. & Wakabayashi, T. (1982) J. Biochem. 92, 871) reported that the ATP-induced disassembly of chicken gizzard "thick filaments" resulted in myosin monomers with "looped" tails [27].
 

Analytical, diagnostic and therapeutic context of CEFBUPERAZONE

References

  1. Characterization of a Na+/H+ antiporter gene of Escherichia coli. Goldberg, E.B., Arbel, T., Chen, J., Karpel, R., Mackie, G.A., Schuldiner, S., Padan, E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Late sigma factor of bacteriophage T4. Formation and properties of RNA polymerase-promoter complexes. Malik, S., Goldfarb, A. J. Biol. Chem. (1988) [Pubmed]
  3. In vitro activity of Sch 34343 and cefbuperazone against anaerobic bacteria. Shafran, S.D., Wong, J., Chow, A.W. Antimicrob. Agents Chemother. (1985) [Pubmed]
  4. In vitro activity of cefbuperazone against Bacteroides spp. Dias, M.B., Jacobus, N.V., Gorbach, S.L., Tally, F.P. Antimicrob. Agents Chemother. (1985) [Pubmed]
  5. In vitro activity of cefbuperazone against anaerobic bacteria. Wexler, H., Carter, W.T., Harris, B.H., Finegold, S.M. Antimicrob. Agents Chemother. (1985) [Pubmed]
  6. In vivo activity of cefbuperazone (T-1982) against various experimental infections in mice. Suzuki, I., Senda, H., Yokota, T. J. Antibiot. (1985) [Pubmed]
  7. A second DNA methyltransferase repair enzyme in Escherichia coli. Rebeck, G.W., Coons, S., Carroll, P., Samson, L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Protein binding sites are conserved in U1 small nuclear RNA from insects and mammals. Wieben, E.D., Madore, S.J., Pederson, T. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  9. Subunit structure of extracellular hemoglobin from the polychaete Tylorrhynchus heterochaetus and amino acid sequence of the constituent polypeptide chain (IIC). Suzuki, T., Furukohri, T., Gotoh, T. J. Biol. Chem. (1985) [Pubmed]
  10. Conformational states of smooth muscle myosin. Effects of light chain phosphorylation and ionic strength. Trybus, K.M., Lowey, S. J. Biol. Chem. (1984) [Pubmed]
  11. A complementary DNA oligomer releases a transcription pause complex. Fisher, R., Yanofsky, C. J. Biol. Chem. (1983) [Pubmed]
  12. In vitro activity of cefbuperazone, a new cephamycin, against anaerobic bacteria. Prabhala, R.H., Thadepalli, H., Rao, B., Bansal, M.B., Marshall, R. Antimicrob. Agents Chemother. (1985) [Pubmed]
  13. Testicular toxicity of N-methyltetrazolethiol cephalosporin analogs in the juvenile rat. Comereski, C.R., Bregman, C.L., Buroker, R.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1987) [Pubmed]
  14. Impact of cefbuperazone on the colonic microflora in patients undergoing colorectal surgery. Kager, L., Brismar, B., Malmborg, A.S., Nord, C.E. Drugs under experimental and clinical research. (1986) [Pubmed]
  15. Experimental studies on the pharmacokinetics and therapeutic effect of cefbuperazone in biliary infection. Kameyama, J., Tsukamoto, M., Asano, T., Senda, H., Amemiya, K., Murakami, N., Kaneda, N. Current medical research and opinion. (1989) [Pubmed]
  16. The activity of cefbuperazone, a 7 alpha-methoxy 7 beta acyl ureido cephalosporin. Neu, H.C., Chin, N.X., Labthavikul, P. Chemioterapia : international journal of the Mediterranean Society of Chemotherapy. (1985) [Pubmed]
  17. The NADPH-dependent O-.2-generating oxidase from human neutrophils. Gabig, T.G. J. Biol. Chem. (1983) [Pubmed]
  18. Host resistance to an intragastric infection with Listeria monocytogenes in mice depends on cellular immunity and intestinal bacterial flora. Okamoto, M., Nakane, A., Minagawa, T. Infect. Immun. (1994) [Pubmed]
  19. Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy. Ito, K., Hayasaki, M., Tamaya, T. Antimicrob. Agents Chemother. (1990) [Pubmed]
  20. Biliary penetration of cefbuperazone in the presence and absence of obstructive jaundice. Tanaka, H., Nishino, H., Sawada, T., Kawaguchi, N., Azuma, T., Yoshii, Y., Satake, K. J. Antimicrob. Chemother. (1987) [Pubmed]
  21. The intralysosomal pH in cultured human skin fibroblasts in relation to cystine accumulation in patients with cystinosis. Oude Elferink, R.P., Harms, E., Strijland, A., Tager, J.M. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  22. In vitro and in vivo antibacterial activity of T-1982, a new semisynthetic cephamycin antibiotic. Tai, M., Fukuoka, Y., Yotsuji, A., Kumano, K., Takahata, M., Mikami, H., Yasuda, T., Saikawa, I., Mitsuhashi, S. Antimicrob. Agents Chemother. (1982) [Pubmed]
  23. Proton translocating ATPase in lysosomal membrane ghosts. Evidence that alkaline Mg2+-ATPase acts as a proton pump. Moriyama, Y., Takano, T., Ohkuma, S. J. Biochem. (1984) [Pubmed]
  24. Effect of mutation, electric membrane potential, and metabolic inhibitors on the accessibility of nucleic acids to ethidium bromide in Escherichia coli cells. Lambert, B., Le Pecq, J.B. Biochemistry (1984) [Pubmed]
  25. In vitro activity of cefbuperazone compared with that of other new beta-lactam agents against anaerobic gram-negative bacilli and contribution of beta-lactamase to resistance. Del Bene, V.E., Carek, P.J., Twitty, J.A., Burkey, L.J. Antimicrob. Agents Chemother. (1985) [Pubmed]
  26. A possible evolutionary relationship between plant trypsin inhibitor, alpha-amylase inhibitor, and mammalian pancreatic secretory trypsin inhibitor (Kazal). Odani, S., Koide, T., Ono, T. J. Biochem. (1983) [Pubmed]
  27. Electron microscopic studies on myosin molecules from chicken gizzard muscle III. Myosin dimers. Onishi, H., Wakabayashi, T. J. Biochem. (1984) [Pubmed]
  28. Effects of cefbuperazone on the chemiluminescence of human neutrophils. Kumae, T., Saburi, Y., Nasu, M., Misumi, J., Kawata, N. Chemotherapy. (1989) [Pubmed]
 
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