Gene Review:
Tg - thyroglobulin
Mus musculus
Synonyms:
Tgn, Thyroglobulin, cog
- The congenital goiter mutation is linked to the thyroglobulin gene in the mouse. Taylor, B.A., Rowe, L. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Pax8 has a key role in thyroid cell differentiation. Pasca di Magliano, M., Di Lauro, R., Zannini, M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Genetic deletion of sonic hedgehog causes hemiagenesis and ectopic development of the thyroid in mouse. Fagman, H., Grände, M., Gritli-Linde, A., Nilsson, M. Am. J. Pathol. (2004)
- A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. Kim, P.S., Hossain, S.A., Park, Y.N., Lee, I., Yoo, S.E., Arvan, P. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis. Verginis, P., Stanford, M.M., Carayanniotis, G. J. Immunol. (2002)
- Independent expression of a regulatory idiotype on heavy and light chains. A further immunochemical analysis with anti-heavy and anti-light chain antibodies. Zanetti, M., Rogers, J. J. Immunol. (1987)
- Defective thyroglobulin synthesis and secretion causing goiter and hypothyroidism. Medeiros-Neto, G., Targovnik, H.M., Vassart, G. Endocr. Rev. (1993)
- Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction. Witsch, E.J., Cao, H., Fukuyama, H., Weigert, M. J. Exp. Med. (2006)
- A thyroxine-containing peptide can induce murine experimental autoimmune thyroiditis. Hutchings, P.R., Cooke, A., Dawe, K., Champion, B.R., Geysen, M., Valerio, R., Roitt, I.M. J. Exp. Med. (1992)
- Effect of the synthetic immunomodulator, linomide, on experimental models of thyroiditis. Hutchings, P., Hedlund, G., Dawe, K., Howlett, S., Cooke, A. Immunology (1999)
- Results of passive and active immunization directed against ferric aerobactin in experimental enterobacterial infections in mice and chickens. Le Roy, D., Crouzier, C., Dho-Moulin, M., Dumont, A.S., Bouchet, A., Lafont, J.P., Andremont, A. Res. Microbiol. (1995)
- TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. Zannini, M., Avantaggiato, V., Biffali, E., Arnone, M.I., Sato, K., Pischetola, M., Taylor, B.A., Phillips, S.J., Simeone, A., Di Lauro, R. EMBO J. (1997)
- A dominant negative CREB (cAMP response element-binding protein) isoform inhibits thyrocyte growth, thyroid-specific gene expression, differentiation, and function. Nguyen, L.Q., Kopp, P., Martinson, F., Stanfield, K., Roth, S.I., Jameson, J.L. Mol. Endocrinol. (2000)
- Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice. Meunier, D., Aubin, J., Jeannotte, L. Dev. Dyn. (2003)
- Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma. Johnston, D., Hatzis, D., Sunday, M.E. Oncogene (1998)
- Thyrotropin dependent and independent thyroid cell lines selected from FRTL-5 derived tumors grown in nude mice. Ossendorp, F.A., Bruning, P.F., Schuuring, E.M., Van Den Brink, J.A., van der Heide, D., De Vijlder, J.J., De Bruin, T.W. Endocrinology (1990)
- Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Marians, R.C., Ng, L., Blair, H.C., Unger, P., Graves, P.N., Davies, T.F. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Gene expression profile in thyroid of transgenic mice overexpressing the adenosine receptor 2a. Goffard, J.C., Jin, L., Mircescu, H., Van Hummelen, P., Ledent, C., Dumont, J.E., Corvilain, B. Mol. Endocrinol. (2004)
- Inherited congenital goiter in mice. Beamer, W.G., Maltais, L.J., DeBaets, M.H., Eicher, E.M. Endocrinology (1987)
- Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. VII. Generation of thyroid-specific cytotoxic effector cells. Salamero, J., Charreire, J. Cell. Immunol. (1985)
- Viral mediated gene therapy for the management of metastatic thyroid carcinoma. DeGroot, L.J., Zhang, R. Curr. Drug Targets Immune Endocr. Metabol. Disord. (2004)
- IFN-gamma-deficient mice develop severe granulomatous experimental autoimmune thyroiditis with eosinophil infiltration in thyroids. Tang, H., Sharp, G.C., Peterson, K.P., Braley-Mullen, H. J. Immunol. (1998)
- HMGI-C gene expression is not required for in vivo thyroid cell transformation. Scala, S., Portella, G., Vitagliano, D., Ledent, C., Chiappetta, G., Giancotti, V., Dumont, J., Fusco, A. Carcinogenesis (2001)
- The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci. Eicher, E.M., Lee, B.K. Genetics (1990)
- Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. Ledent, C., Denef, J.F., Cottecchia, S., Lefkowitz, R., Dumont, J., Vassart, G., Parmentier, M. Endocrinology (1997)
- Thyroglobulin increases cell proliferation and suppresses Pax-8 in mesangial cells. Sellitti, D.F., Suzuki, K., Doi, S.Q., LaGranha, C., Machado, M., Matos, T., Kohn, L.D. Biochem. Biophys. Res. Commun. (2001)
- Mutant gene-induced disorders of structure, function and thyroglobulin synthesis in congenital goitre (cog/cog) in mice. Adkison, L.R., Taylor, S., Beamer, W.G. J. Endocrinol. (1990)
- The thyroglobulin gene resides on chromosome 8 in man and on chromosome 7 in the rat. Brocas, H., Szpirer, J., Lebo, R.V., Levan, G., Szpirer, C., Cheung, M.C., Vassart, G. Cytogenet. Cell Genet. (1985)