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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1LBK18     tetraethylazanium hydrochloride

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Disease relevance of tetraethylammonium


High impact information on tetraethylammonium


Biological context of tetraethylammonium

  • To determine whether these assemblies were functional we created rSK3VF, an rSK3 mutant with an enhanced affinity for tetraethylammonium chloride (TEA) (IC50 of 0.3 mM) [9].
  • However, vasodilation caused by the 2 lower doses of BK were significantly attenuated after K(Ca) channel activity was blocked with tetraethylammonium chloride (0.1 mg. 100 mL FAV(-1). min(-1)), suggesting that in the lower dose range, BK mediates vasodilation through the opening of vascular potassium channels [10].
  • On the basis of its kinetics, a reversal potential of -85 +/- 6 mV (n = 6), sensitivity to intracellularly injected tetraethylammonium chloride (TEA), and its slow and partial inactivation (approximately 25%) this mechanism is classified as a delayed rectifier potassium conductance [11].
  • The thermal stability of interspecies DNA duplexes was measured in a solvent (2.4 M tetraethylammonium chloride) that suppresses the effect of base composition on melting temperature [12].
  • Tetraethylammonium chloride (TEA), a blocker of the calcium (Ca2+)-dependent K+ conductances of GH3, was found to reversibly inhibit cell proliferation, as measured by 3H-thymidine incorporation [13].

Anatomical context of tetraethylammonium


Associations of tetraethylammonium with other chemical compounds


Gene context of tetraethylammonium


Analytical, diagnostic and therapeutic context of tetraethylammonium


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  9. The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system. Monaghan, A.S., Benton, D.C., Bahia, P.K., Hosseini, R., Shah, Y.A., Haylett, D.G., Moss, G.W. J. Biol. Chem. (2004) [Pubmed]
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  17. The effect of tetraethylammonium chloride on calcium fluxes in smooth muscle from rabbit main pulmonary artery. Haeusler, G., Kuhn, H., Thorens, S. J. Physiol. (Lond.) (1980) [Pubmed]
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  25. PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP. Mei, Y.A., Vaudry, D., Basille, M., Castel, H., Fournier, A., Vaudry, H., Gonzalez, B.J. Eur. J. Neurosci. (2004) [Pubmed]
  26. Correlation of hepatocyte growth factor-induced proliferation and calcium-activated potassium current in human gastric cancer cells. Liu, S.I., Chi, C.W., Lui, W.Y., Mok, K.T., Wu, C.W., Wu, S.N. Biochim. Biophys. Acta (1998) [Pubmed]
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  31. Calcium dependent action potentials produced in leech Retzius cells by tetraethylammonium chloride. Kleinhaus, A.L., Prichard, J.W. J. Physiol. (Lond.) (1975) [Pubmed]
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