Disease relevance of TRIETHYLENE GLYCOL DIMETHACRYLATE

• In the in situ experiments guinea pigs (n = 4) received TEGDMA (0.02 mmol/kg body weight labelled with a tracer dose 14C-TEGDMA 0.7 kBq/g body weight) injected into the jugular vein [1].

High impact information on TRIETHYLENE GLYCOL DIMETHACRYLATE

• The induction of apoptosis by TEGDMA in human pulp cells has been associated with an inhibition of the phosphatidylinositol 3-kinase (PI3-K) cell-survival signaling pathway [2].
• The formation of micronuclei is indicative of chromosomal damage and the induction of DNA strand breaks detected with monomers like TEGDMA and 2-hydroxyethyl methacrylate (HEMA) [2].
• Moreover, Akt phosphorylation was inhibited in the presence of TEGDMA [3].
• At low concentrations, urethane dimethacrylate (UDMA), bisglycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), and bis-phenol A (BPA) increased spleen cell proliferation to concanavalin A (con A) [4].
• After 3h incubation, TEGDMA induced an increase of lipid peroxidation associated with LDH leakage [5].

Biological context of TRIETHYLENE GLYCOL DIMETHACRYLATE

• Here we examined apoptosis and necrosis induced by TEGDMA in human primary pulp cells [3].
• Thus, the present results suggest that TEGDMA induces lipid peroxidation and mitochondrial damage, which contribute to cell death [5].
• TEGDMA and BisGMA monomers were incubated with human saliva derived esterase activity (HSDEA) and their respective hydrolysis was monitored using high performance liquid chromatography (HPLC) [6].
• It is concluded that MMA, HEMA, and TEGDMA interfere with the function of blood vessels by inducing vasorelaxation via different mechanisms, which, depending upon the type of resin, may at least involve the release of nitric oxide and prostanoid(s), and the activation of smooth muscle K(ATP) channels [7].

Anatomical context of TRIETHYLENE GLYCOL DIMETHACRYLATE

• This is demonstrated by the collapse of mitochondrial membrane potential (MMP) in HGF treated with TEGDMA [5].
• Recent studies in vitro have demonstrated that TEGDMA induced GSH depletion and production of radical oxygen species (ROS) in human gingival fibroblasts (HGF) but the exact mechanism of these events remains unclear [5].
• Glybenclamide selectively attenuated TEGDMA-induced relaxation of the tissues with and without endothelium to a similar extent, suggesting the activation of vascular smooth muscle K(ATP) channels by this resin [7].
• OBJECTIVES: Previous work has demonstrated diffusion of the monomer triethylene glycol dimethacrylate (TEGDMA) from resin composite through dentine in vitro [8].
• The excretion of the dental composite component triethylene glycol dimethacrylate (TEGDMA) in feces and urine in vivo and, using the pendular perfusion technique with segments of jejunum and colon, the biliary and enteric excretion in situ were investigated in anesthetized guinea pigs [1].

Associations of TRIETHYLENE GLYCOL DIMETHACRYLATE with other chemical compounds

• She and 2 dental nurses were allergic to aliphatic acrylates, including triethylene glycol dimethacrylate (TREGDMA) and triethylene diglycol diacrylate (TREGDA) [9].
• Methyl methacrylate (MMA) and triethylene glycol dimethacrylate (TEGDMA) were common sensitizers in dental technicians but not in other patients [10].
• Studies have shown that inflammatory (cholesterol esterase, CE) and salivary (pseudo-cholinesterase, PCE) enzymes can cause the breakdown of bisphenol-A diglycidyl dimethacrylate (bisGMA) and triethylene glycol dimethacrylate (TEGDMA) components from composite resins [11].

Gene context of TRIETHYLENE GLYCOL DIMETHACRYLATE

• The maximum MTBS and FS values of the resin adhesives were observed when the ratio of Bis-GMA/TEGDMA was 60/40 [12].
• These results suggest that depression of PI3K signaling may be a primary target in TEGDMA-induced apoptosis [3].
• The K(m) for triethylene glycol dimethacrylate (TEGDMA) was 197 microM for ACHE and 1107 microM for CHE [13].
• Upon biodegradation, the Z250 composite yielded higher amounts of BisGMA and TEGDMA related products relative to the TPH composite [6].

Analytical, diagnostic and therapeutic context of TRIETHYLENE GLYCOL DIMETHACRYLATE

• However, a population shift among cells in apoptosis and necrosis was detected when cell cultures were exposed to 2 mmol/L TEGDMA [3].

References