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Chemical Compound Review

CHEMBL2074648     (2S)-2-amino-3- (carboxymethylcarbamoyl)pro...

Synonyms: AR-1J3566, AKOS006274882, NSC 186908, AC1L413E, 3790-52-1, ...
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Disease relevance of beta-Aspartylglycine


High impact information on beta-Aspartylglycine


Anatomical context of beta-Aspartylglycine

  • Relative caecal weights, the ratio of secondary to primary bile acids, the presence of filamentous segmented bacteria in the small intestine and faecal beta-aspartylglycine were normal 5 days after direct contact and 15 days after indirect contact [8].
  • Bodyweight and the following intestinal parameters were determined for the 3 groups: colonization resistance to E. coli, relative caecal weight, villus:crypt ratio (ileum), beta-aspartylglycine (faeces), volatile fatty acids (caecum), and bile acids (faeces) [9].

Associations of beta-Aspartylglycine with other chemical compounds


Gene context of beta-Aspartylglycine


Analytical, diagnostic and therapeutic context of beta-Aspartylglycine

  • This method was used to determine beta-aspartylpeptidase activity in faecal supernatants of healthy human volunteers and antibiotic-treated patients with beta-aspartylglycine as substrate [14].
  • This study describes and compares four methods--(1) dansylation with thin-layer chromatography, (2) ion-exchange chromatography, (3) thin-layer electrophoresis, (4) high-voltage paper electrophoresis--to determine the concentration of beta-aspartylglycine in fecal supernatants of leukemic patients treated with antimicrobial agents [15].
  • This substance was isolated from hemodialysate by the methods of ion-exchange chromatography, gel-filtration and paper electrophoresis, and identified as beta-aspartylglycine by amino acid analysis, N-terminal amino acid determination and comparison with authentic sample synthesized in this laboratory [2].
  • The results indicate that monitoring the normalization (association) process can be accomplished in several ways, but the level of colonization-resistance is most easily measured by high-voltage paper electrophoresis of faecal supernatants to determine the concentration of beta-aspartylglycine [16].


  1. Influence of temocillin on colonisation resistance and consequences for therapy. De Vries-Hospers, H.G., Hofstra, W., Welling, G.W., Van der Waaij, D. Drugs (1985) [Pubmed]
  2. Identification of beta-aspartylglycine in uremic serum and its toxicity. Gejyo, F., Kinoshita, Y., Ito, G., Ikenaka, T. Contributions to nephrology. (1978) [Pubmed]
  3. Enterobacteriaceae suppression by three different oral doses of polymyxin E in human volunteers. van Saene, J.J., van Saene, H.K., Tarko-Smit, N.J., Beukeveld, G.J. Epidemiol. Infect. (1988) [Pubmed]
  4. Confirmation of D-aspartic acid in the novel dipeptide beta-aspartylglycine isolated from tissue extract of Aplysia kurodai. Sato, M., Yamaguchi, T., Kanno, N., Sato, Y. Biochem. J. (1989) [Pubmed]
  5. Synthesis of the novel dipeptide beta-aspartylglycine by Aplysia ganglia. McCaman, M.W., Stetzler, J. J. Neurochem. (1985) [Pubmed]
  6. Isolation and characterization of 101-beta-lysozyme that possesses the beta-aspartyl sequence at aspartic acid-101. Yamada, H., Ueda, T., Kuroki, R., Fukumura, T., Yasukochi, T., Hirabayashi, T., Fujita, K., Imoto, T. Biochemistry (1985) [Pubmed]
  7. Selective decontamination of the digestive tract by pipemidic acid. Muytjens, H.L., van Veldhuizen, G.L., Welling, G.W., van der Ros-van de Repe, J., Boerema, H.B., van der Waaij, D. Antimicrob. Agents Chemother. (1983) [Pubmed]
  8. 'Normalization' of germfree mice after direct and indirect contact with mice having a 'normal' intestinal microflora. Koopman, J.P., Kennis, H.M., Lankhorst, A., Welling, G.W., Hectors, M.P., Nagengast, F. Lab. Anim. (1986) [Pubmed]
  9. The 'normalization' of germ-free rabbits with host-specific caecal microflora. Boot, R., Koopman, J.P., Kruijt, B.C., Lammers, R.M., Kennis, H.M., Lankhorst, A., Mullink, J.W., Stadhouders, A.M., De Boer, H., Welling, G.W. Lab. Anim. (1985) [Pubmed]
  10. Establishment of a biochemically active intestinal ecosystem in ex-germfree rats. Midtvedt, T., Carlstedt-Duke, B., Höverstad, T., Midtvedt, A.C., Norin, K.E., Saxerholt, H. Appl. Environ. Microbiol. (1987) [Pubmed]
  11. Enteral nutrition and the function of the intestinal microflora in healthy adults. Leijonmarck, C.E., Carlstedt-Duke, B., Gustafsson, A., Midtvedt, A.C., Norin, K.E., Saxerholt, H., Midtvedt, T. Clinical nutrition (Edinburgh, Scotland) (1990) [Pubmed]
  12. Biochemical intestinal parameters in pigs reared outdoors and indoors, and in germ-free pigs. Collinder, E., Cardona, M.E., Kozakova, H., Norin, E., Stern, S., Midtvedt, T. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. (2002) [Pubmed]
  13. Six intestinal microflora-associated characteristics in sport horses. Collinder, E., Lindholm, A., Midtvedt, T., Norin, E. Equine Vet. J. (2000) [Pubmed]
  14. Determination of beta-aspartylpeptidase activity in human faeces by high-performance liquid chromatography using pre-column derivatization with phenyl isothiocyanate. van der Leij, F.R., Welling, G.W. J. Chromatogr. (1986) [Pubmed]
  15. Comparison of methods for the determination of beta-aspartylglycine in fecal supernatants of leukemic patients treated with antimicrobial agents. Welling, G.W. J. Chromatogr. (1982) [Pubmed]
  16. Biochemical effects on germ-free mice of association with several strains of anaerobic bacteria. Welling, G.W., Groen, G., Tuinte, J.H., Koopman, J.P., Kennis, H.M. J. Gen. Microbiol. (1980) [Pubmed]
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