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Gene Review

ANAPC10  -  anaphase promoting complex subunit 10

Homo sapiens

Synonyms: APC10, Anaphase-promoting complex subunit 10, Cyclosome subunit 10, DKFZP564L0562, DOC1
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Disease relevance of ANAPC10

  • BACKGROUND: We previously reported differential expression of the growth suppressor, deleted in oral cancer-1 (DOC-1), in microsatellite-unstable (MSI+) versus microsatellite-stable colorectal cancer (CRC) cell lines [1].

High impact information on ANAPC10

  • We further provide biochemical evidence that the C-terminus of APC10 binds to CDC27/APC3, an APC subunit that contains multiple tetratrico peptide repeats [2].
  • Unexpectedly, this structure is highly similar to ligand-binding domains of several bacterial and eukaryotic proteins, such as galactose oxidase and coagulation factor Va, raising the possibility that APC10 may function by binding a yet unidentified ligand [2].
  • APC activation by CDH1 depends on a conserved C-terminal motif that is also found in CDC20 and APC10 [3].
  • We have further identified an APC10 homology region, which we propose to call the DOC domain, in several protein sequences that also contain either cullin or HECT domains [4].
  • Here, we show that Doc1/Apc10 is a subunit of the yeast APC throughout the cell cycle [4].

Biological context of ANAPC10


Anatomical context of ANAPC10


Associations of ANAPC10 with chemical compounds

  • From the total of 50 subjects, a new relationship was developed: Log10 (APC10) = 0.68 log10 (HPC20 X SS) (r = 0.82) from which 46 of 50 (92%) of allergen PC20 values fall within 2 doubling concentrations of the regression line (and all within 3) [9].

Other interactions of ANAPC10

  • In addition, the protein levels of HEF1 are subjected to the regulation of overexpressed APC10 and CDH1 [10].
  • Significantly, EGF stimulated autophosphorylation of the EGFR of APC-10 was 8-10-fold lower than that of PC-10 [7].

Analytical, diagnostic and therapeutic context of ANAPC10


  1. Deleted in oral cancer-1 expression upregulates proapoptosis elements in microsatellite-unstable human colorectal cancer. Sotsky Kent, T., Yuan, Z., Miller, A., Weber, T.K. Ann. Surg. Oncol. (2004) [Pubmed]
  2. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt, K.S., Vodermaier, H.C., Jacob, U., Gieffers, C., Gmachl, M., Peters, J.M., Huber, R., Sondermann, P. Nat. Struct. Biol. (2001) [Pubmed]
  3. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Vodermaier, H.C., Gieffers, C., Maurer-Stroh, S., Eisenhaber, F., Peters, J.M. Curr. Biol. (2003) [Pubmed]
  4. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. Grossberger, R., Gieffers, C., Zachariae, W., Podtelejnikov, A.V., Schleiffer, A., Nasmyth, K., Mann, M., Peters, J.M. J. Biol. Chem. (1999) [Pubmed]
  5. Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. Kurasawa, Y., Todokoro, K. Oncogene (1999) [Pubmed]
  6. Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis. Eiras, S., Fernández, P., Piñeiro, R., Iglesias, M.J., González-Juanatey, J.R., Lago, F. Cardiovasc. Res. (2006) [Pubmed]
  7. Loss of cytotoxic effect of epidermal growth factor (EGF) on EGF receptor overexpressing cells is associated with attenuation of EGF receptor tyrosine kinase activity. Gardner, D.P., Shimizu, N. J. Cell. Physiol. (1994) [Pubmed]
  8. PLXDC1 (TEM7) is identified in a genome-wide expression screen of glioblastoma endothelium. Beaty, R.M., Edwards, J.B., Boon, K., Siu, I.M., Conway, J.E., Riggins, G.J. J. Neurooncol. (2007) [Pubmed]
  9. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Cockcroft, D.W., Murdock, K.Y., Kirby, J., Hargreave, F. Am. Rev. Respir. Dis. (1987) [Pubmed]
  10. Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. Nourry, C., Maksumova, L., Pang, M., Liu, X., Wang, T. BMC Cell Biol. (2004) [Pubmed]
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