Gene Review:
EBP - emopamil binding protein (sterol isomerase)
Homo sapiens
Synonyms:
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase, CDPX2, CHO2, CPX, CPXD, ...
- Mutations in the gene encoding 3 beta-hydroxysteroid-delta 8, delta 7-isomerase cause X-linked dominant Conradi-Hünermann syndrome. Braverman, N., Lin, P., Moebius, F.F., Obie, C., Moser, A., Glossmann, H., Wilcox, W.R., Rimoin, D.L., Smith, M., Kratz, L., Kelley, R.I., Valle, D. Nat. Genet. (1999)
- CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation. Grant, C., Nonnemacher, M., Jain, P., Pandya, D., Irish, B., Williams, S.C., Wigdahl, B. Virology (2006)
- CCAAT/enhancer-binding protein-d is induced in mesangial area during the early stages of anti-Thy1.1 glomerulonephritis and regulates cell proliferation and inflammatory gene expression in cultured rat mesangial cells. Miyoshi, K., Okura, T., Fukuoka, T., Higaki, J. Clin. Exp. Nephrol. (2007)
- Disruption of a C/EBP binding site in the factor IX promoter is associated with haemophilia B. Crossley, M., Brownlee, G.G. Nature (1990)
- Structural and functional evolution of human immunodeficiency virus type 1 long terminal repeat CCAAT/enhancer binding protein sites and their use as molecular markers for central nervous system disease progression. Hogan, T.H., Stauff, D.L., Krebs, F.C., Gartner, S., Quiterio, S.J., Wigdahl, B. J. Neurovirol. (2003)
- Children and evidence-based practice. Burns, B.J. Psychiatr. Clin. North Am. (2003)
- Enhancing the EBP repertoire of substance abuse counselors: A commentary on Kerwin, Walker-Smith, and Kirby. Horvatich, P.K. Journal of substance abuse treatment. (2006)
- McBindall--a better name for CCAAT/enhancer binding proteins? McKnight, S.L. Cell (2001)
- Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry, J.M., Gormally, E., Means, G.D., Zhao, W., Meindl, A., Kelley, R.I., Boyd, Y., Herman, G.E. Nat. Genet. (1999)
- Impaired cyclic AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line. Vallejo, M., Gosse, M.E., Beckman, W., Habener, J.F. Mol. Cell. Biol. (1995)
- Prostaglandin E(2)-mediated activation of HIV-1 long terminal repeat transcription in human T cells necessitates CCAAT/enhancer binding protein (C/EBP) binding sites in addition to cooperative interactions between C/EBPbeta and cyclic adenosine 5'-monophosphate response element binding protein. Dumais, N., Bounou, S., Olivier, M., Tremblay, M.J. J. Immunol. (2002)
- Role of CAAT-enhancer binding protein isoforms in the cytokine regulation of acute-phase plasma protein genes. Baumann, H., Morella, K.K., Campos, S.P., Cao, Z., Jahreis, G.P. J. Biol. Chem. (1992)
- Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1. Srisodsai, A., Kurotani, R., Chiba, Y., Sheikh, F., Young, H.A., Donnelly, R.P., Kimura, S. J. Biol. Chem. (2004)
- C/EBP alpha and beta mimic retinoic acid activation of IGFBP-5 in neuroblastoma cells by a mechanism independent from binding to their site. Cesi, V., Giuffrida, M.L., Vitali, R., Tanno, B., Mancini, C., Calabretta, B., Raschellà, G. Exp. Cell Res. (2005)
- Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity. Moebius, F.F., Fitzky, B.U., Wietzorrek, G., Haidekker, A., Eder, A., Glossmann, H. Biochem. J. (2003)
- Insulin-like growth factor-I augments interleukin-8 promoter activity through induction of activator protein-1 complex formation. Kooijman, R., Coppens, A., Van den Keybus, C. Int. J. Biochem. Cell Biol. (2006)
- The Conradi-Hünermann-Happle syndrome (CDPX2) and emopamil binding protein: novel mutations, and somatic and gonadal mosaicism. Has, C., Bruckner-Tuderman, L., Müller, D., Floeth, M., Folkers, E., Donnai, D., Traupe, H. Hum. Mol. Genet. (2000)
- Identification of a novel mutation in 3beta-hydroxysteroid-Delta8-Delta7-isomerase in a case of Conradi-Hünermann-Happle syndrome. Becker, K., Csikós, M., Horváth, A., Kárpáti, S. Exp. Dermatol. (2001)
- Phenylalkylamine Ca2+ antagonist binding protein. Molecular cloning, tissue distribution, and heterologous expression. Hanner, M., Moebius, F.F., Weber, F., Grabner, M., Striessnig, J., Glossmann, H. J. Biol. Chem. (1995)
- Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Pirot, P., Ortis, F., Cnop, M., Ma, Y., Hendershot, L.M., Eizirik, D.L., Cardozo, A.K. Diabetes (2007)
- Adipocyte differentiation and leptin expression. Hwang, C.S., Loftus, T.M., Mandrup, S., Lane, M.D. Annu. Rev. Cell Dev. Biol. (1997)
- Antagonism between C/EBPbeta and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors. Querfurth, E., Schuster, M., Kulessa, H., Crispino, J.D., Döderlein, G., Orkin, S.H., Graf, T., Nerlov, C. Genes Dev. (2000)
- GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells. Kim, S.H., Hwang, C.I., Park, W.Y., Lee, J.H., Song, Y.S. Carcinogenesis (2006)
- Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis. Eiras, S., Fernández, P., Piñeiro, R., Iglesias, M.J., González-Juanatey, J.R., Lago, F. Cardiovasc. Res. (2006)
- The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive protein gene promoter. Cha-Molstad, H., Young, D.P., Kushner, I., Samols, D. Mol. Immunol. (2007)
- SR31747A is a sigma receptor ligand exhibiting antitumoural activity both in vitro and in vivo. Berthois, Y., Bourrié, B., Galiègue, S., Vidal, H., Carayon, P., Martin, P.M., Casellas, P. Br. J. Cancer (2003)
- Identification of common transcriptional regulatory elements in interleukin-17 target genes. Shen, F., Hu, Z., Goswami, J., Gaffen, S.L. J. Biol. Chem. (2006)
- The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals. Horndasch, M., Lienkamp, S., Springer, E., Schmitt, A., Pavenstädt, H., Walz, G., Gloy, J. Oncogene (2006)
- Regulation of the human oxytocin receptor by nuclear factor-kappaB and CCAAT/enhancer-binding protein-beta. Terzidou, V., Lee, Y., Lindström, T., Johnson, M., Thornton, S., Bennett, P.R. J. Clin. Endocrinol. Metab. (2006)
- Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). Ron, D., Brasier, A.R., McGehee, R.E., Habener, J.F. J. Clin. Invest. (1992)
- Identification of a C/EBP-Rel complex in avian lymphoid cells. Diehl, J.A., Hannink, M. Mol. Cell. Biol. (1994)
- Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression. Khanna-Gupta, A., Zibello, T., Sun, H., Gaines, P., Berliner, N. Blood (2003)