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Gene Review

CDIPT  -  CDP-diacylglycerol--inositol 3...

Homo sapiens

Synonyms: PI synthase, PIS, PIS1, Phosphatidylinositol synthase, PtdIns synthase
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Disease relevance of CDIPT


High impact information on CDIPT

  • These data illustrate that the levels of Cds1 and Pis1 protein expression are not critical determinants of cellular PtdIns content and argue against a determining role for the activity of either of these enzymes in the regulation of PtdIns biosynthesis [4].
  • Strongly luminescent heterocycles based on the INI unit were synthesized by 1,3-dipolar cycloaddition reactions between pyrido[2,1-a]isoindole (PIS) and acetylene or ethylene derivatives [5].
  • Inositol monophosphatase (EC is a crucial enzyme in the biosynthesis of free myo-inositol from inositol-1-phosphate, a key substrate for the phosphatidylinositol synthase in mycobacteria [6].
  • The results strongly suggest that at least a portion of the PtdIns synthase in turkey erythrocytes is located in the plasma membrane and has direct access to an agonist-sensitive pool of inositol phospholipids [7].
  • Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes [7].

Biological context of CDIPT

  • PIS was also found to be associated with a strongly predominant haplotype and seems to be the second most recent PI common allele, while M2 and M3 show weaker associations, suggesting more ancient origins of their corresponding mutations [8].
  • These data demonstrate that changes in PtdIns synthase activity by some agents acting via different mechanisms are associated with parallel changes in thymidine incorporation, and suggest that PtdIns production is tightly coupled to cell proliferation in human amnion cells [9].
  • An insertion element (Pis1) has been found integrated into the 5' flanking sequence of the legC legumin seed storage protein gene [10].
  • The new model, which also accounts for the CIS and PIS distinction, shows more reasonable results since the frequencies of tolerant, immune or autoimmune responses to an antigen are now correct [11].

Anatomical context of CDIPT


Associations of CDIPT with chemical compounds

  • There were two coincident peaks of carbachol-stimulated [3H]CMP-phosphatidate and PtdIns synthase activity, respectively [1].
  • The first peak of accumulated [3H]CMP-phosphatidate and PtdIns synthase activity is characteristic of a 'light vesicle' fraction, since it sediments at sucrose densities similar to that of endocytosed 125I-transferrin [1].
  • The changes in PtdIns synthase activity occurred in parallel with changes in mitogenic activity caused by increasing the dose of exogenous Ca2+ or A23187 [9].
  • Median deviations of PIS with PIM from that with TTC were only 1.01% and -0.53%, at 24 hr and 48 hr [15].
  • In cells with PtdIns synthase activity decreased by exogenous Ca2+, [3H]thymidine incorporation was also inhibited, while A23187 caused dose-dependent enhancement of thymidine incorporation [9].

Other interactions of CDIPT


Analytical, diagnostic and therapeutic context of CDIPT

  • Re: The role of radical cystectomy in the management of high grade superficial bladder cancer (PA, P1, PIS and P2) [20].
  • One liter PIS, prewarmed to 40 degrees C, was used for each lavage [14].
  • For 65 rehabilitation participants, 5-year patients satisfaction scores did not relate closely with VAS, PIS, and OPQ improvements during treatment (r = 0.15, 0.01, and 0.14) [21].
  • In PNHS and PIS close correlation (r = 0.75, P < 0.0001 and r = 0.71, P < 0.005) was demonstrated between postnicardipine improvement (21 +/- 4% to 37 +/- 9%, P < 0.0001, and 16 +/- 7% to 20 +/- 8%, P < 0.0005) and 6 months after PTCA improvement (21 +/- 4% to 33 +/- 7%, P < 0.0001, and 16 +/- 7% to 19 +/- 9%, P < 0.0005) of wall motion [2].


  1. Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. Sillence, D.J., Downes, C.P. Biochem. J. (1993) [Pubmed]
  2. Pre-PTCA detection of chronic but reversible postischemic myocardial dysfunction by nicardipine. Pust, B., Surlan, M. Angiology. (1998) [Pubmed]
  3. Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells. Nakamura, J., Del Monte, M.A., Shewach, D., Lattimer, S.A., Greene, D.A. Am. J. Physiol. (1992) [Pubmed]
  4. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. Lykidis, A., Jackson, P.D., Rock, C.O., Jackowski, S. J. Biol. Chem. (1997) [Pubmed]
  5. Synthesis and properties of highly fluorescent indolizino[3,4,5-ab]isoindoles. Mitsumori, T., Bendikov, M., Dautel, O., Wudl, F., Shioya, T., Sato, H., Sato, Y. J. Am. Chem. Soc. (2004) [Pubmed]
  6. Purification and biochemical characterization of Mycobacterium tuberculosis SuhB, an inositol monophosphatase involved in inositol biosynthesis. Nigou, J., Dover, L.G., Besra, G.S. Biochemistry (2002) [Pubmed]
  7. Direct labelling of hormone-sensitive phosphoinositides by a plasma-membrane-associated PtdIns synthase in turkey erythrocytes. Vaziri, C., Downes, C.P., Macfarlane, S.C. Biochem. J. (1993) [Pubmed]
  8. Analysis of the allelic diversity of a (CA)n repeat polymorphism among alpha 1-antitrypsin gene products from northern Portugal. Rocha, J., Pinto, D., Santos, M.T., Amorim, A., Amil-Dias, J., Cardoso-Rodrigues, F., Aguiar, A. Hum. Genet. (1997) [Pubmed]
  9. Evidence of a role for phosphatidylinositol synthesis in human amnion cell proliferation. Ohno, T., Imai, A., Furui, T., Matsunami, K., Matsuda, T., Tamaya, T. Biol. Reprod. (1992) [Pubmed]
  10. A transposon-like structure in the 5' flanking sequence of a legumin gene from Pisum sativum. Shirsat, A.H. Mol. Gen. Genet. (1988) [Pubmed]
  11. Natural and induced tolerance in an immune network model. León, K., Carneiro, J., Peréz, R., Montero, E., Lage, A. J. Theor. Biol. (1998) [Pubmed]
  12. Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes. McPhee, F., Lowe, G., Vaziri, C., Downes, C.P. Biochem. J. (1991) [Pubmed]
  13. Ontogenesis of female-to-male sex-reversal in XX polled goats. Pailhoux, E., Vigier, B., Vaiman, D., Servel, N., Chaffaux, S., Cribiu, E.P., Cotinot, C. Dev. Dyn. (2002) [Pubmed]
  14. The effect of postbreeding uterine lavage on pregnancy rate in mares. Brinsko, S.P., Varner, D.D., Blanchard, T.L., Meyers, S.A. Theriogenology (1990) [Pubmed]
  15. Percent infarct mapping: an R1-map-based CE-MRI method for determining myocardial viability distribution. Surányi, P., Kiss, P., Brott, B.C., Simor, T., Elgavish, A., Ruzsics, B., Saab-Ismail, N.H., Elgavish, G.A. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2006) [Pubmed]
  16. myo-[3H]-inositol loaded erythrocytes and white ghosts: two models to investigate the phosphatidylinositol synthesis in human red cells. Piatti, E., Piacentini, M.P., Fraternale, D., Bucchini, A., Mangani, F., Accorsi, A. Biochimie (1999) [Pubmed]
  17. Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles. de Serres, F.J., Luisetti, M., Ferrarotti, I., Blanco, I., Fernández-Bustillo, E. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo. (2005) [Pubmed]
  18. Phosphatidylinositol synthase from mammalian tissues. Antonsson, B. Biochim. Biophys. Acta (1997) [Pubmed]
  19. Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Implications for its priming action on human neutrophils. MacPhee, C.H. Biochem. J. (1992) [Pubmed]
  20. Re: The role of radical cystectomy in the management of high grade superficial bladder cancer (PA, P1, PIS and P2). Sandeman, T.F. J. Urol. (1992) [Pubmed]
  21. Chronic low back pain: The relationship between patient satisfaction and pain, impairment, and disability outcomes. Hazard, R.G., Haugh, L.D., Green, P.A., Jones, P.L. Spine. (1994) [Pubmed]
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