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Gene Review

AGAP2  -  ArfGAP with GTPase domain, ankyrin repeat...

Homo sapiens

Synonyms: AGAP-2, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, CENTG1, Centaurin-gamma-1, Cnt-g1, ...
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Disease relevance of CENTG1


Psychiatry related information on CENTG1

  • The Child Behaviour Check List (CBCL; Achenbach and Edelbrock, 1979), the Piers-Harris (1984) Self-Esteem measure and the Harter and Pike (1984) Self-Competence Scale were completed and questionnaires and semi-structured interviews were conducted with both the girls and their clinicians [6].

High impact information on CENTG1

  • The sensitivities of hematopoietic colony-forming cells (CFC) to N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide (NSC-249992) (m-AMSA) were measured with an in vitro clonogenic assay, a modification of the Robinson and Pike human marrow culture system [7].
  • Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival [8].
  • Snyderman and Pike 159 and Chusid and co-workers 160 emphasized the existence of a large number of other neutrophil bactericidal abnormalities resulting from as yet unexplained cellular defects [9].
  • Based on these results, we concluded that the closely related Arf GAPs, AGAP1 and AGAP2, distinguish between these related heterotetrameric adaptor protein complexes to specifically regulate AP-3 endosomes and AP-1 recycling endosomes [10].
  • Aromatic cluster 1 of alpha-lactalbumin (LA), a substructure adjacent to the cleft, is important for its interaction with galactosyltransferase (GT) and effects on glucose binding in the lactose synthase complex [Grobler, J. A., Wang, M., Pike, A. K., & Brew, K. (1994) J. Biol. Chem. 269, 5106-5114] [11].

Biological context of CENTG1

  • The PIKE family includes three members, PIKE-L, PIKE-S and PIKE-A, which are originated from a single gene (CENTG1) through alternative splicing or differential transcription initiation [12].
  • These studies demonstrate that this cosmid is derived from a remarkably gene-dense region and add two new transcripts (KIAA0167 and 6E5.2) to the list of sequences that are expressed in tumors bearing amplification of this region [13].
  • WAODA aids in implementation of dental health education program in Pike County [14].
  • Against the backcloth of te quantitative picture of general practice activity described in the companion paper (Beaumont and Pike, Ecol. Dis. 2, 45, 1983), the question of health-environment interaction is addressed [15].
  • Fluorimetric titrations of parvalbumin II (pI 4.2) of pike (Pike II) with Ca2+ and Tb3+ show the CD and EF binding sites to be non-equivalent [16].

Anatomical context of CENTG1

  • A matched pairs analysis to evaluate crude relative risk according to Pike [7] and a logistic model fitted by maximum likelihood according to the method described by Cox [8] supported the conclusion that there was an elevated risk of cancer in the cervix among Lesotho women who consumed indigenous alcohols [17].
  • The bone marrow granulocyte-macrophage progenitor cells (CFU-C) in patients with systemic lupus erythematosus (SLE) were estimated according to the double-layer soft agar system of Pike and Robinson [18].

Associations of CENTG1 with chemical compounds

  • Helmet use was significantly (P < .001) higher in Beachwood, with legislation and education, than in the other communities; helmet use was significantly (P < .001) higher in Orange, with legislation alone, than in Moreland Hills and Pepper Pike, with no programs [19].
  • For Pike III, acidic pH, sodium dodecyl sulfate or complete removal of Ca2+ show little effect in the far ultraviolet region but rather strong effects in the near ultraviolet [20].

Analytical, diagnostic and therapeutic context of CENTG1

  • The apparatus is particularly useful for the microtitre tray antibody-forming cell plaque assay described by Pike et al [21].
  • Data from a case-control study of breast cancer in 441 cases and matched controls aged less than or equal to 38 in Los Angeles is fitted to two models of carcinogenesis: the two-stage model of Moolgavkar and Knudson; and a multistage adaptation of the log/log model proposed by Pike et al [22].


  1. Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas. Knobbe, C.B., Trampe-Kieslich, A., Reifenberger, G. Neuropathol. Appl. Neurobiol. (2005) [Pubmed]
  2. Risk factors for breast cancer according to family history of breast cancer.For the Nurses' Health Study Research Group. Colditz, G.A., Rosner, B.A., Speizer, F.E. J. Natl. Cancer Inst. (1996) [Pubmed]
  3. Epidemiology of sarcoidosis in the Isle of Man--2: Evidence for space-time clustering. Hills, S.E., Parkes, S.A., Baker, S.B. Thorax (1987) [Pubmed]
  4. Mathematical models of ovarian cancer incidence. Rosner, B.A., Colditz, G.A., Webb, P.M., Hankinson, S.E. Epidemiology (Cambridge, Mass.) (2005) [Pubmed]
  5. Quantitation of differential sensitivity of normal marrow myeloid progenitor cells to anthracene derivatives. Bron, D., Dodion, P., Rozencweig, M., Delforge, A., Mattelaer, M.A., Kenis, Y., Stryckmans, P. Investigational new drugs. (1986) [Pubmed]
  6. The specific effects of incest on prepubertal girls from dysfunctional families. Hotte, J.P., Rafman, S. Child abuse & neglect. (1992) [Pubmed]
  7. Chemotherapeutic sensitivity of normal and leukemic hematopoietic progenitor cells to N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide, a new anticancer agent. Spiro, T.E., Socquet, M., Delforge, A., Stryckmans, P. J. Natl. Cancer Inst. (1981) [Pubmed]
  8. Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival. Tang, X., Feng, Y., Ye, K. Cell Death Differ. (2007) [Pubmed]
  9. Cell biology of leukocyte abnormalities--membrane and cytoskeletal function in normal and defective cells. A review. Oliver, J.M. Am. J. Pathol. (1978) [Pubmed]
  10. The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. Nie, Z., Fei, J., Premont, R.T., Randazzo, P.A. J. Cell. Sci. (2005) [Pubmed]
  11. Functional site in alpha-lactalbumin encompasses a region corresponding to a subsite in lysozyme and parts of two adjacent flexible substructures. Malinovskii, V.A., Tian, J., Grobler, J.A., Brew, K. Biochemistry (1996) [Pubmed]
  12. PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell deathPIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. Chan, C.B., Ye, K., Chan, C.B., Ye, K. J. Cell. Mol. Med. (2007) [Pubmed]
  13. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. Elkahloun, A.G., Krizman, D.B., Wang, Z., Hofmann, T.A., Roe, B., Meltzer, P.S. Genomics (1997) [Pubmed]
  14. WAODA aids in implementation of dental health education program in Pike County. Kaiser, J.H. The Ohio dental journal. (1975) [Pubmed]
  15. General practice--a quantitative study, 2. Spatial and temporal variation in morbidity. Pike, L.A., Beaumont, C.D. Ecology of disease. (1983) [Pubmed]
  16. Interaction of parvalbumin of pike II with calcium and terbium ions. Eberspach, I., Strassburger, W., Glatter, U., Gerday, C., Wollmer, A. Biochim. Biophys. Acta (1988) [Pubmed]
  17. Cervical cancer in relation to tobacco and alcohol consumption in Lesotho, southern Africa. Martin, P.M., Hill, G.B. Cancer Detect. Prev. (1984) [Pubmed]
  18. Colony forming units in culture and colony stimulating activity of systemic lupus erythematosus. Yamauchi, K. Tokai J. Exp. Clin. Med. (1981) [Pubmed]
  19. Association between bicycle helmet legislation, bicycle safety education, and use of bicycle helmets in children. Macknin, M.L., Medendorp, S.V. Archives of pediatrics & adolescent medicine. (1994) [Pubmed]
  20. Conformational studies on parvalbumins by circular dichroism. Closset, J., Gerday, C. Biochim. Biophys. Acta (1975) [Pubmed]
  21. An indexing stage for microscopic scanning of microtitre tray wells. Darling, W., Justin, O., Pike, B.L., Jennings, G., Shortman, K. J. Immunol. Methods (1982) [Pubmed]
  22. Fitting models of carcinogenesis to a case-control study of breast cancer. Krailo, M., Thomas, D.C., Pike, M.C. Journal of chronic diseases. (1987) [Pubmed]
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