Disease relevance of CENTG1

• Here, we investigated two further Pi3k/Akt pathway genes, namely PIK3CA (3q26.3) and phosphatidylinositol-3-kinase enhancer (PIKE) (CENTG1, 12q14), for genetic alteration and aberrant expression in a series of 97 primary glioblastomas [1].
• PURPOSE: Using a modified extended log-incidence Pike model, we prospectively examined the impact of risk factors for breast cancer among women with and without a family history of the disease [2].
• The case-control test for space-time clustering developed by Pike and Smith was applied to 96 cases of sarcoidosis diagnosed in the Isle of Man from 1962 to 1983 [3].
• BACKGROUND: Pike has proposed "protected time" as one summary method for modeling reproductive risk factors in relation to ovarian cancer incidence [4].
• The effect of 3 anthracene derivatives, mitoxantrone, ametantrone, bisantrene, on 4 normal human bone marrows, was studied using the myeloid stem cell assay developed by Pike and Robinson, in order to define to what extent this test could be used to predict the relative clinical hematologic toxicity of new anticancer agents [5].

Psychiatry related information on CENTG1

• The Child Behaviour Check List (CBCL; Achenbach and Edelbrock, 1979), the Piers-Harris (1984) Self-Esteem measure and the Harter and Pike (1984) Self-Competence Scale were completed and questionnaires and semi-structured interviews were conducted with both the girls and their clinicians [6].

High impact information on CENTG1

• The sensitivities of hematopoietic colony-forming cells (CFC) to N-[4-(9-acridinylamino)-3-methoxyphenyl]-methanesulfonamide (NSC-249992) (m-AMSA) were measured with an in vitro clonogenic assay, a modification of the Robinson and Pike human marrow culture system [7].
• Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival [8].
• Snyderman and Pike 159 and Chusid and co-workers 160 emphasized the existence of a large number of other neutrophil bactericidal abnormalities resulting from as yet unexplained cellular defects [9].
• Based on these results, we concluded that the closely related Arf GAPs, AGAP1 and AGAP2, distinguish between these related heterotetrameric adaptor protein complexes to specifically regulate AP-3 endosomes and AP-1 recycling endosomes [10].
• Aromatic cluster 1 of alpha-lactalbumin (LA), a substructure adjacent to the cleft, is important for its interaction with galactosyltransferase (GT) and effects on glucose binding in the lactose synthase complex [Grobler, J. A., Wang, M., Pike, A. K., & Brew, K. (1994) J. Biol. Chem. 269, 5106-5114] [11].

Biological context of CENTG1

• The PIKE family includes three members, PIKE-L, PIKE-S and PIKE-A, which are originated from a single gene (CENTG1) through alternative splicing or differential transcription initiation [12].
• These studies demonstrate that this cosmid is derived from a remarkably gene-dense region and add two new transcripts (KIAA0167 and 6E5.2) to the list of sequences that are expressed in tumors bearing amplification of this region [13].
• WAODA aids in implementation of dental health education program in Pike County [14].
• Against the backcloth of te quantitative picture of general practice activity described in the companion paper (Beaumont and Pike, Ecol. Dis. 2, 45, 1983), the question of health-environment interaction is addressed [15].
• Fluorimetric titrations of parvalbumin II (pI 4.2) of pike (Pike II) with Ca2+ and Tb3+ show the CD and EF binding sites to be non-equivalent [16].

Anatomical context of CENTG1

• A matched pairs analysis to evaluate crude relative risk according to Pike [7] and a logistic model fitted by maximum likelihood according to the method described by Cox [8] supported the conclusion that there was an elevated risk of cancer in the cervix among Lesotho women who consumed indigenous alcohols [17].
• The bone marrow granulocyte-macrophage progenitor cells (CFU-C) in patients with systemic lupus erythematosus (SLE) were estimated according to the double-layer soft agar system of Pike and Robinson [18].

Associations of CENTG1 with chemical compounds

• Helmet use was significantly (P < .001) higher in Beachwood, with legislation and education, than in the other communities; helmet use was significantly (P < .001) higher in Orange, with legislation alone, than in Moreland Hills and Pepper Pike, with no programs [19].
• For Pike III, acidic pH, sodium dodecyl sulfate or complete removal of Ca2+ show little effect in the far ultraviolet region but rather strong effects in the near ultraviolet [20].

Analytical, diagnostic and therapeutic context of CENTG1

• The apparatus is particularly useful for the microtitre tray antibody-forming cell plaque assay described by Pike et al [21].
• Data from a case-control study of breast cancer in 441 cases and matched controls aged less than or equal to 38 in Los Angeles is fitted to two models of carcinogenesis: the two-stage model of Moolgavkar and Knudson; and a multistage adaptation of the log/log model proposed by Pike et al [22].

References