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MeSH Review

Great Britain

 
 
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Disease relevance of Great Britain

 

Psychiatry related information on Great Britain

  • AIMS: Since its launch in the prescribing market in 1999 for the treatment of opiate dependence, buprenorphine has rapidly become established as an alternative to methadone treatment in the United Kingdom [6].
  • The following oral fluid opiate cutoffs were evaluated: the GC/MS limit of quantification (LOQ) of 2.5 mg/l; 15 microg/l currently used for oral fluid testing in the United Kingdom (UK); 30 microg/l (Opiate CRS cutoff); and 40 microg/l, the proposed Substance Abuse and Mental Health Services Administration (SAMHSA) cutoff [7].
  • METHODS: Incidence rates of CJD, based on person-year denominators, were assessed in a cohort of 1,848 patients treated with hGH in the United Kingdom from 1959 through 1985 and followed to the end of 2000 [8].
  • Over 90% of children met the Physical Activity Guidelines for Adolescents (PAGA) and the United States' Healthy People Objective No. 22.6; 80% met the United Kingdom Expert Consensus Group guideline; and 70% met the Healthy People Objective No. 22 [9].
 

High impact information on Great Britain

 

Chemical compound and disease context of Great Britain

 

Biological context of Great Britain

  • Almost half the sample shared the same Y-chromosome haplotype, which has not been observed in control samples either from the same geographic region or from the United Kingdom as a whole [20].
  • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials [21].
  • PURPOSE: This phase I study was performed to evaluate the safety and pharmacokinetics of escalating doses of Marimastat (British Biotech, Inc, Oxford, United Kingdom) in patients with advanced malignancies and to determine the phase II recommended dose to be used in subsequent studies [22].
  • METHODS: Frequencies of BcHE K variant, alpha2M insertion and/or deletion polymorphism, the ApoE common polymorphisms and promoter variants at ApoE-491 and -291, were examined by fluorescent RFLP in DNA from 276 United Kingdom Prospective Diabetes Study Type II diabetic subjects and 351 non-diabetic subjects from the Diabetes In Families study [23].
  • Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population [24].
 

Anatomical context of Great Britain

 

Associations of Great Britain with chemical compounds

 

Gene context of Great Britain

 

Analytical, diagnostic and therapeutic context of Great Britain

References

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  3. Hepatocellular carcinoma in primary biliary cirrhosis: detection by alpha-fetoprotein estimation. Melia, W.M., Johnson, P.J., Neuberger, J., Zaman, S., Portmann, B.C., Williams, R. Gastroenterology (1984) [Pubmed]
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  14. TPA patent battle rages in United Kingdom. Johnston, K. Nature (1987) [Pubmed]
  15. Molecular follow-up in gastric mucosa-associated lymphoid tissue lymphomas: early analysis of the LY03 cooperative trial. Bertoni, F., Conconi, A., Capella, C., Motta, T., Giardini, R., Ponzoni, M., Pedrinis, E., Novero, D., Rinaldi, P., Cazzaniga, G., Biondi, A., Wotherspoon, A., Hancock, B.W., Smith, P., Souhami, R., Cotter, F.E., Cavalli, F., Zucca, E. Blood (2002) [Pubmed]
  16. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. Nabholtz, J.M., Buzdar, A., Pollak, M., Harwin, W., Burton, G., Mangalik, A., Steinberg, M., Webster, A., von Euler, M. J. Clin. Oncol. (2000) [Pubmed]
  17. The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. Mann, J.R., Raafat, F., Robinson, K., Imeson, J., Gornall, P., Sokal, M., Gray, E., McKeever, P., Hale, J., Bailey, S., Oakhill, A. J. Clin. Oncol. (2000) [Pubmed]
  18. Phase I/II study of iodine 131 metaiodobenzylguanidine in chemoresistant neuroblastoma: a United Kingdom Children's Cancer Study Group investigation. Lashford, L.S., Lewis, I.J., Fielding, S.L., Flower, M.A., Meller, S., Kemshead, J.T., Ackery, D. J. Clin. Oncol. (1992) [Pubmed]
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  20. Surnames and the Y chromosome. Sykes, B., Irven, C. Am. J. Hum. Genet. (2000) [Pubmed]
  21. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Kottaridis, P.D., Gale, R.E., Frew, M.E., Harrison, G., Langabeer, S.E., Belton, A.A., Walker, H., Wheatley, K., Bowen, D.T., Burnett, A.K., Goldstone, A.H., Linch, D.C. Blood (2001) [Pubmed]
  22. Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. Wojtowicz-Praga, S., Torri, J., Johnson, M., Steen, V., Marshall, J., Ness, E., Dickson, R., Sale, M., Rasmussen, H.S., Chiodo, T.A., Hawkins, M.J. J. Clin. Oncol. (1998) [Pubmed]
  23. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Hashim, Y., Shepherd, D., Wiltshire, S., Holman, R.R., Levy, J.C., Clark, A., Cull, C.A. Diabetologia (2001) [Pubmed]
  24. Linkage analysis of markers on chromosome 11q13 with asthma and atopy in a United Kingdom population. Simon Thomas, N., Wilkinson, J., Lonjou, C., Morton, N.E., Holgate, S.T. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  25. Humoral inhibitor of rat hepatocyte DNA synthesis from patients with fulminant liver failure. Yamada, H., Toda, G., Yoshiba, M., Hashimoto, N., Ikeda, Y., Mitsui, H., Kurokawa, K., Sugata, F., Hughes, R.D., Williams, R. Hepatology (1994) [Pubmed]
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  28. Lack of association of T cell receptor V beta 8 polymorphism with rheumatoid arthritis in United Kingdom and Italian white patients. Lunardi, C., Ibberson, M., Zeminian, S., De Sandre, G., So, A.K. Ann. Rheum. Dis. (1994) [Pubmed]
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  36. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Barton, A., Bowes, J., Eyre, S., Spreckley, K., Hinks, A., John, S., Worthington, J. Arthritis Rheum. (2004) [Pubmed]
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