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Gene Review

Slc25a20  -  solute carrier family 25...

Rattus norvegicus

Synonyms: CAC, Cact, Carnitine/acylcarnitine translocase, Mitochondrial carnitine/acylcarnitine carrier protein, Solute carrier family 25 member 20
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Disease relevance of Slc25a20


High impact information on Slc25a20


Biological context of Slc25a20

  • The methylation of C-A is very low in the trinucleotides ACA and CAC, the other C-A containing trinucleotides in DNA are much better methylacceptors [8].
  • The tandem repeat and its adjacent region consisted of a similar motif of CAC/TCC/AC/T [9].
  • The cellular weakening or cytoxic consequences of CAC are intertwined in the most fundamental sense with energy intake, production, storage, and mobilization [10].
  • Four groups of male Sprague-Dawley rats were used: CAC (24, control for acclimated), HAC (24, heat acclimated), TCAC (3, telemetry implanted control for acclimation), and THAC (3, telemetry implanted, heat acclimated) [11].
  • The impact of CAC on the HPA axis to increase GCs makes this energy regulatory hormone along with pancreatic hormones a potential major player in the site-specific organ pathologies associated with CAC [10].

Anatomical context of Slc25a20


Associations of Slc25a20 with chemical compounds


Other interactions of Slc25a20


Analytical, diagnostic and therapeutic context of Slc25a20

  • Gel mobility-shift assays demonstrate that the transcriptionally active 68-kDa fragment of the sterol regulatory element (SRE-1)-binding protein assays (SREBP-1) binds to an oligonucleotide containing the wild-type sequence but not to an oligonucleotide in which the CAC has been mutated [5].


  1. Identification by site-directed mutagenesis and chemical modification of three vicinal cysteine residues in rat mitochondrial carnitine/acylcarnitine transporter. Tonazzi, A., Giangregorio, N., Indiveri, C., Palmieri, F. J. Biol. Chem. (2005) [Pubmed]
  2. Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats. Paradies, G., Ruggiero, F.M., Petrosillo, G., Quagliariello, E. FEBS Lett. (1996) [Pubmed]
  3. Alterations in carnitine-acylcarnitine translocase activity and in phospholipid composition in heart mitochondria from hypothyroid rats. Paradies, G., Ruggiero, F.M., Petrosillo, G., Quagliariello, E. Biochim. Biophys. Acta (1997) [Pubmed]
  4. Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Nelson, C., Shen, L.P., Meister, A., Fodor, E., Rutter, W.J. Genes Dev. (1990) [Pubmed]
  5. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Ericsson, J., Jackson, S.M., Lee, B.C., Edwards, P.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. Vancutsem, P.M., Lazarus, P., Williams, G.M. Cancer Res. (1994) [Pubmed]
  7. Elucidation of the mechanism by which (+)-acylcarnitines inhibit mitochondrial fatty acid transport. Baillet, L., Mullur, R.S., Esser, V., McGarry, J.D. J. Biol. Chem. (2000) [Pubmed]
  8. Non-C-G recognition sequences of DNA cytosine-5-methyltransferase from rat liver. Hubrich-Kühner, K., Buhk, H.J., Wagner, H., Kröger, H., Simon, D. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  9. Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression. Saijoh, K., Saito, N., Lee, M.J., Fujii, M., Kobayashi, T., Sumino, K. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  10. Alcohol, corticosteroids, energy utilization, and hippocampal endangerment. Eskay, R.L., Chautard, T., Torda, T., Daoud, R.I., Hamelink, C. Ann. N. Y. Acad. Sci. (1995) [Pubmed]
  11. Telemetry augments the validity of the rat as a model for heat acclimation. Matthew, C.B. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  12. Site-directed mutagenesis and chemical modification of the six native cysteine residues of the rat mitochondrial carnitine carrier: implications for the role of cysteine-136. Indiveri, C., Giangregorio, N., Iacobazzi, V., Palmieri, F. Biochemistry (2002) [Pubmed]
  13. Characterization of carnitine acylcarnitine translocase system of heart mitochondria. Pande, S.V., Parvin, R. J. Biol. Chem. (1976) [Pubmed]
  14. Enhancement of mitochondrial carnitine and carnitine acylcarnitine translocase-mediated transport of fatty acids into liver mitochondria under ketogenic conditions. Parvin, R., Pande, S.V. J. Biol. Chem. (1979) [Pubmed]
  15. Submitochondrial and subcellular distributions of the carnitine-acylcarnitine carrier. Fraser, F., Zammit, V.A. FEBS Lett. (1999) [Pubmed]
  16. Time-dependent effects of chloroquine on pH of hepatocyte lysosomes. Tietz, P.S., Yamazaki, K., LaRusso, N.F. Biochem. Pharmacol. (1990) [Pubmed]
  17. Carnitine-acylcarnitine translocase. Inhibition by alpha-cyano-4-hydroxycinnamate and evidence for separate identity from the pyruvate transporting system of mitochondria. Parvin, R., Pande, S.V. J. Biol. Chem. (1978) [Pubmed]
  18. Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. Murthy, M.S., Pande, S.V. J. Biol. Chem. (1984) [Pubmed]
  19. Increased carnitine palmitoyltransferase in cardiac myocytes is mediated by insulin growth factor I. Hudson, E.K., Wang, D., Bieber, L.L., Buja, L.M., McMillin, J.B. Am. J. Physiol. (1996) [Pubmed]
  20. Acetyl-L-carnitine prevents total body hydroxyl free radical and uric acid production induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the rat. Loots, d.u. .T., Mienie, L.J., Bergh, J.J., Van der Schyf, C.J. Life Sci. (2004) [Pubmed]
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