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Gene Review

Dnajc5  -  DnaJ (Hsp40) homolog, subfamily C, member 5

Mus musculus

Synonyms: 2610314I24Rik, AU018536, CSP, Csp, Cysteine string protein, ...
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Disease relevance of Dnajc5

  • The DNA coding for the circumsporozoite protein of Plasmodium falciparum (CSP; aa 1-412) has been placed under the control of the mycobacterial promoter derived from the gene encoding the 64-kDa antigen of Mycobacterium bovis-BCG [1].
  • Inoculation of the recombinant BCG to mice did not induce humoral response to CSP nor proliferative response to CSP Th2R CD4+ T lymphocyte epitope [1].
  • OBJECTIVE: The recent success of a Plasmodium falciparum malaria vaccine consisting of circumsporozoite (CS) protein (CSP) T and B cell epitopes has rekindled interest in the development of a pre-erythrocytic vaccine [2].
  • METHODS: Well-characterized CSP-specific neutralizing B cell epitopes and a 'universal' T cell epitope were combined with a particulate carrier platform, the hepatitis B core antigen (HBcAg), to produce a novel pre-erythrocytic vaccine candidate [2].

High impact information on Dnajc5


Biological context of Dnajc5

  • Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis [5].
  • The purified material, when injected into mice, generated only modest antibody responses, although antisera from immunized mice reacted with control CSP antigens carrying or not the major immunodominant repeat region [6].

Anatomical context of Dnajc5

  • The synaptic vesicle protein CSP alpha prevents presynaptic degeneration [7].
  • We conclude that CSP is associated with insulin secretory granules and that CSP participates in the molecular regulation of insulin exocytosis by mechanisms not involving changes in the activity of voltage-gated Ca2+-channels [5].
  • Punctate CSP-like immunoreactivity (CSP-LI) was demonstrated in most islets of Langerhans cells, acinar cells and nerve fibers of the rat pancreas [5].
  • In addition, the interaction of Csp1 with syntaxin 4 suggests that this Csp isoform may play a role in insulin-stimulated fusion of GSVs with the plasma membrane [8].
  • Immunization with either DNA encoding the PyCSP or irradiated sporozoites demonstrated that this CTL epitope is subdominant since it is not recognized in the context of whole CSP immunization [9].

Other interactions of Dnajc5


Analytical, diagnostic and therapeutic context of Dnajc5

  • Tunicamycin had only a slight effect on the initial times and rates of CSP appearance on the cell surface; some apparent intracellular redistribution of CSP was detected by immunofluorescence [3].
  • In situ hybridization and RT-PCR analysis demonstrated CSP mRNA expression in insulin-producing cells [5].
  • One clone (B6), produced by the fusion of spleen cells from mice that had been given three immunizations, secreted an IgG antibody that did produce a CSP response on the sporozoite and neutralized the infectivity of the parasite [10].


  1. Stable integration and expression of the Plasmodium falciparum circumsporozoite protein coding sequence in mycobacteria. Haeseleer, F., Pollet, J.F., Haumont, M., Bollen, A., Jacobs, P. Mol. Biochem. Parasitol. (1993) [Pubmed]
  2. A malaria vaccine candidate based on a hepatitis B virus core platform. Sällberg, M., Hughes, J., Jones, J., Phillips, T.R., Milich, D.R. Intervirology (2002) [Pubmed]
  3. Role of carbohydrates in protein secretion and turnover: effects of tunicamycin on the major cell surface glycoprotein of chick embryo fibroblasts. Olden, K., Pratt, R.M., Yamada, K.M. Cell (1978) [Pubmed]
  4. Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells. Yamada, K.M., Ohanian, S.H., Pastan, I. Cell (1976) [Pubmed]
  5. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. Brown, H., Larsson, O., Bränström, R., Yang, S.N., Leibiger, B., Leibiger, I., Fried, G., Moede, T., Deeney, J.T., Brown, G.R., Jacobsson, G., Rhodes, C.J., Braun, J.E., Scheller, R.H., Corkey, B.E., Berggren, P.O., Meister, B. EMBO J. (1998) [Pubmed]
  6. Plasmodium falciparum: recombinant baculoviruses direct the expression of circumsporozoite proteins in Spodoptera frugiperda cell cultures. Jacobs, P., Massaer, M., Heinderyckx, M., Milican, F., Gilles, P., van Opstal, O., Voet, P., Gheysen, D., Bollen, A. Mol. Biol. Rep. (1991) [Pubmed]
  7. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Fernández-Chacón, R., Wölfel, M., Nishimune, H., Tabares, L., Schmitz, F., Castellano-Muñoz, M., Rosenmund, C., Montesinos, M.L., Sanes, J.R., Schneggenburger, R., Südhof, T.C. Neuron (2004) [Pubmed]
  8. The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4. Chamberlain, L.H., Graham, M.E., Kane, S., Jackson, J.L., Maier, V.H., Burgoyne, R.D., Gould, G.W. J. Cell. Sci. (2001) [Pubmed]
  9. A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture. Franke, E.D., Sette, A., Sacci, J., Southwood, S., Corradin, G., Hoffman, S.L. Infect. Immun. (2000) [Pubmed]
  10. Production of monoclonal antibodies by hybridomas sensitized to sporozoites of Plasmodium berghei. Danforth, H.D., Campbell, G.H., Leef, M.F., Beaudoin, R.L. J. Parasitol. (1982) [Pubmed]
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