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Gene Review

Gab2  -  growth factor receptor bound protein 2...

Mus musculus

Synonyms: AI463667, D130058I17Rik, GRB2-associated binder 2, GRB2-associated-binding protein 2, Growth factor receptor bound protein 2-associated protein 2, ...
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Disease relevance of Gab2


High impact information on Gab2

  • Dos/Gab family scaffolding adapters (Dos, Gab1, Gab2) bind several signal relay molecules, including the protein-tyrosine phosphatase Shp-2 and phosphatidylinositol-3-OH kinase (PI(3)K); they are also implicated in growth factor, cytokine and antigen receptor signal transduction [2].
  • Biochemical analyses reveal that signalling pathways dependent on PI(3)K, a critical component of Fc(epsilon)RI signalling, are defective in Gab2-/- mast cells [2].
  • Here we report that Gab2-/- mice are viable and generally healthy; however, the response (for example, degranulation and cytokine gene expression) of Gab2-/- mast cells to stimulation of the high affinity immunoglobulin-epsilon (IgE) receptor Fc(epsilon)RI is defective [2].
  • Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation [5].
  • Gab2-deficient mast cells were severely impaired in chemokine mRNA induction whereas LAT-deficient mast cells showed a more pronounced defect in cytokines [6].

Biological context of Gab2


Anatomical context of Gab2


Associations of Gab2 with chemical compounds

  • Our findings provide the first evidence that Gab2 is an important player in neural differentiation, partly by acting downstream of bFGF to mediate survival through phosphoinositide 3 kinase-AKT [9].
  • A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation [9].
  • Since this association involves the proline-rich sequences of Gab2, it probably involves the Src homology 3 domain of Src kinase [11].

Regulatory relationships of Gab2


Other interactions of Gab2


  1. The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions. Zompi, S., Gu, H., Colucci, F. J. Leukoc. Biol. (2004) [Pubmed]
  2. Essential role for Gab2 in the allergic response. Gu, H., Saito, K., Klaman, L.D., Shen, J., Fleming, T., Wang, Y., Pratt, J.C., Lin, G., Lim, B., Kinet, J.P., Neel, B.G. Nature (2001) [Pubmed]
  3. Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice. Nepom, G.T., Nelson, K.A., Holbeck, S.L., Hellström, I., Hellström, K.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  4. Role of Gab2 in mammary tumorigenesis and metastasis. Ke, Y., Wu, D., Princen, F., Nguyen, T., Pang, Y., Lesperance, J., Muller, W.J., Oshima, R.G., Feng, G.S. Oncogene (2007) [Pubmed]
  5. Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. Gu, H., Pratt, J.C., Burakoff, S.J., Neel, B.G. Mol. Cell (1998) [Pubmed]
  6. Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. Gonzalez-Espinosa, C., Odom, S., Olivera, A., Hobson, J.P., Martinez, M.E., Oliveira-Dos-Santos, A., Barra, L., Spiegel, S., Penninger, J.M., Rivera, J. J. Exp. Med. (2003) [Pubmed]
  7. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses. Zhu, Q.S., Robinson, L.J., Roginskaya, V., Corey, S.J. Blood (2004) [Pubmed]
  8. Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. Gu, H., Botelho, R.J., Yu, M., Grinstein, S., Neel, B.G. J. Cell Biol. (2003) [Pubmed]
  9. A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid-induced neuronal differentiation. Mao, Y., Lee, A.W. J. Cell Biol. (2005) [Pubmed]
  10. Gads/Grb2-mediated association with LAT is critical for the inhibitory function of Gab2 in T cells. Yamasaki, S., Nishida, K., Sakuma, M., Berry, D., McGlade, C.J., Hirano, T., Saito, T. Mol. Cell. Biol. (2003) [Pubmed]
  11. Epidermal growth factor-induced DNA synthesis. Key role for Src phosphorylation of the docking protein Gab2. Kong, M., Mounier, C., Dumas, V., Posner, B.I. J. Biol. Chem. (2003) [Pubmed]
  12. New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Gu, H., Maeda, H., Moon, J.J., Lord, J.D., Yoakim, M., Nelson, B.H., Neel, B.G. Mol. Cell. Biol. (2000) [Pubmed]
  13. Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes. Kong, M., Mounier, C., Wu, J., Posner, B.I. J. Biol. Chem. (2000) [Pubmed]
  14. Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. Yu, M., Lowell, C.A., Neel, B.G., Gu, H. J. Immunol. (2006) [Pubmed]
  15. Scaffolding protein Gab2 mediates fibroblast transformation by the SEA tyrosine kinase. Ischenko, I., Petrenko, O., Gu, H., Hayman, M.J. Oncogene (2003) [Pubmed]
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