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Gene Review

Gata3  -  GATA binding protein 3

Mus musculus

Synonyms: GATA-binding factor 3, Gata-3, Trans-acting T-cell-specific transcription factor GATA-3, jal
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Disease relevance of Gata3


High impact information on Gata3


Biological context of Gata3


Anatomical context of Gata3


Associations of Gata3 with chemical compounds

  • We then measured serum urea levels, performed histomorphometric analysis for tubular necrosis and regeneration, and evaluated the mRNA expression of HO-1, t-bet, Gata-3 and MCP-1 by real-time PCR at 24, 48 and 120 h after surgery [9].

Regulatory relationships of Gata3

  • Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney [10].
  • AIM: To investigate effects of CpG oligodeoxynucleotide (CpG ODN) on the mRNA expression of transcription factors GATA binding protein 3 (GATA-3) and T-box expressed in T cells (T-bet) in asthmatic mice [11].

Other interactions of Gata3

  • No phenotypic abnormalities were observed in the inner ear of Gata2-/- embryos before lethality at E10.5 and Gata3 expression was unchanged [2].
  • This is the first time when tumor supressor gene Dab2 is shown to be implicated in the defective phenotype of Gata3 mutant mice [7].
  • At the molecular level, the nephric duct of Gata 3(-/-) embryos is characterized by the loss of Ret expression and signaling, which may contribute to the guidance defect of the nephric duct [10].
  • Gata3 is required for early morphogenesis and Fgf10 expression during otic development [12].
  • Finally, PG102T and PG102E downregulated the level of GATA-binding protein 3, while inducing that of T-box transcription factor and nuclear factor of activated T cells c2 [13].


  1. Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. van der Wees, J., van Looij, M.A., de Ruiter, M.M., Elias, H., van der Burg, H., Liem, S.S., Kurek, D., Engel, J.D., Karis, A., van Zanten, B.G., de Zeeuw, C.I., Grosveld, F.G., van Doorninck, J.H. Neurobiol. Dis. (2004) [Pubmed]
  2. Partially overlapping expression of Gata2 and Gata3 during inner ear development. Lilleväli, K., Matilainen, T., Karis, A., Salminen, M. Dev. Dyn. (2004) [Pubmed]
  3. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Lim, K.C., Lakshmanan, G., Crawford, S.E., Gu, Y., Grosveld, F., Engel, J.D. Nat. Genet. (2000) [Pubmed]
  4. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Zhu, J., Min, B., Hu-Li, J., Watson, C.J., Grinberg, A., Wang, Q., Killeen, N., Urban, J.F., Guo, L., Paul, W.E. Nat. Immunol. (2004) [Pubmed]
  5. Gene silencing quantitatively controls the function of a developmental trans-activator. Hutchins, A.S., Mullen, A.C., Lee, H.W., Sykes, K.J., High, F.A., Hendrich, B.D., Bird, A.P., Reiner, S.L. Mol. Cell (2002) [Pubmed]
  6. Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Moriguchi, T., Takako, N., Hamada, M., Maeda, A., Fujioka, Y., Kuroha, T., Huber, R.E., Hasegawa, S.L., Rao, A., Yamamoto, M., Takahashi, S., Lim, K.C., Engel, J.D. Development (2006) [Pubmed]
  7. Gene expression analysis of Gata3-/- mice by using cDNA microarray technology. Airik, R., Kärner, M., Karis, A., Kärner, J. Life Sci. (2005) [Pubmed]
  8. Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Kurek, D., Garinis, G.A., van Doorninck, J.H., van der Wees, J., Grosveld, F.G. Development (2007) [Pubmed]
  9. Influence of TH1/TH2 switched immune response on renal ischemia-reperfusion injury. Marques, V.P., Gonçalves, G.M., Feitoza, C.Q., Cenedeze, M.A., Fernandes Bertocchi, A.P., Damião, M.J., Pinheiro, H.S., Antunes Teixeira, V.P., dos Reis, M.A., Pacheco-Silva, A., Saraiva Câmara, N.O. Nephron Exp. Nephrol. (2006) [Pubmed]
  10. Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Grote, D., Souabni, A., Busslinger, M., Bouchard, M. Development (2006) [Pubmed]
  11. Effects of CpG oligodeoxynucleotide on transcription factors GATA-3 and T-bet mRNA expression in asthmatic mice. Wu, Z.Q., Xu, Y.P., Xiang, H., Shen, H.H. Acta Pharmacol. Sin. (2005) [Pubmed]
  12. Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Lilleväli, K., Haugas, M., Matilainen, T., Pussinen, C., Karis, A., Salminen, M. Mech. Dev. (2006) [Pubmed]
  13. Control of IgE and selective T(H)1 and T(H)2 cytokines by PG102 isolated from Actinidia arguta. Park, E.J., Kim, B., Eo, H., Park, K., Kim, Y., Lee, H.J., Son, M., Chang, Y.S., Cho, S.H., Kim, S., Jin, M. J. Allergy Clin. Immunol. (2005) [Pubmed]
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