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Disease relevance of Nippostrongylus


High impact information on Nippostrongylus


Chemical compound and disease context of Nippostrongylus


Biological context of Nippostrongylus


Anatomical context of Nippostrongylus


Associations of Nippostrongylus with chemical compounds


Gene context of Nippostrongylus

  • Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice [8].
  • Injection of a mixture of IL-12 and IL-18 into mice inoculated with Nippostrongylus brasiliensis or injected with anti-IgD induced IFN-gamma-producing cells that inhibit IgE production in them [30].
  • The lack of IL-4Ralpha resulted in markedly diminished, but not absent, TH2 responses after infection with the helminthic parasite Nippostrongylus brasiliensis [31].
  • Moreover, MCP-5 expression was up-regulated in the lungs of mice following aerosolized antigen challenge of sensitized mice, and during the host response to infection with Nippostrongylus brasiliensis [32].
  • Effects on polyclonal Ig production were tested in a Th2 cell-driven immune response in vivo after infection with Nippostrongylus brasiliensis, a parasite that dramatically enhances CD23 expression on B cells [33].

Analytical, diagnostic and therapeutic context of Nippostrongylus


  1. Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection. Kopf, M., Coyle, A.J., Schmitz, N., Barner, M., Oxenius, A., Gallimore, A., Gutierrez-Ramos, J.C., Bachmann, M.F. J. Exp. Med. (2000) [Pubmed]
  2. The effect of methionine and protein deficiency in delaying expulsion of Nippostrongylus brasiliensis in the rat. Cummins, A.G., Bolin, T.D., Duncombe, V.M., Davis, A.E. Am. J. Clin. Nutr. (1986) [Pubmed]
  3. Properties of multinucleated giant cells in a new in vitro model for human granuloma formation. Seitzer, U., Scheel-Toellner, D., Toellner, K.M., Reiling, N., Haas, H., Galle, J., Flad, H.D., Gerdes, J. J. Pathol. (1997) [Pubmed]
  4. Interferon-gamma- and interleukin-4-producing T cells can be primed on dendritic cells in vivo and do not require the presence of B cells. Ronchese, F., Hausmann, B., Le Gros, G. Eur. J. Immunol. (1994) [Pubmed]
  5. Inhibition of neutrophil chemotaxis and activation following decentralization of the superior cervical ganglia. Carter, L., Ferrari, J.K., Davison, J.S., Befus, D. J. Leukoc. Biol. (1992) [Pubmed]
  6. Helper T cells regulate type-2 innate immunity in vivo. Shinkai, K., Mohrs, M., Locksley, R.M. Nature (2002) [Pubmed]
  7. Eosinophil chemotactic factor release from neutrophils by Nippostrongylus brasiliensis larvae. Czarnetzki, B.M. Nature (1978) [Pubmed]
  8. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Urban, J.F., Noben-Trauth, N., Donaldson, D.D., Madden, K.B., Morris, S.C., Collins, M., Finkelman, F.D. Immunity (1998) [Pubmed]
  9. Impaired Th2 subset development in the absence of CD4. Fowell, D.J., Magram, J., Turck, C.W., Killeen, N., Locksley, R.M. Immunity (1997) [Pubmed]
  10. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Zhu, J., Min, B., Hu-Li, J., Watson, C.J., Grinberg, A., Wang, Q., Killeen, N., Urban, J.F., Guo, L., Paul, W.E. Nat. Immunol. (2004) [Pubmed]
  11. Effect of Ascaris suum and other adjuvants on the potentiation of the IgE response in guinea-pigs. Marretta, J., Casey, F.B. Immunology (1979) [Pubmed]
  12. Synthesis and biological evaluation of simplified mycothiazole analogues. Mahler, G., Serra, G., Dematteis, S., Saldaña, J., Domínguez, L., Manta, E. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  13. Host resistance assays as predictive models in styrene immunomodulation. Dogra, R.K., Chandra, K., Chandra, S., Gupta, S., Khanna, S., Srivastava, S.N., Shukla, L.J., Katiyar, J.C., Shanker, R. Int. J. Immunopharmacol. (1992) [Pubmed]
  14. The effect of iron and protein deficiency on plasma levels and parasite uptake of [14C] fenbendazole in rats infected with Nippostrongylus brasiliensis. Prichard, R.K., Kelly, J.D., Bolin, T.D., Duncombe, V.M., Fagan, M.R. The Australian journal of experimental biology and medical science. (1981) [Pubmed]
  15. Use of hydrogen gas (H2) analysis to assess intestinal absorption. Studies in normal rats and in rats infected with the nematode, Nippostrongylus brasiliensis. Carter, E.A., Bloch, K.J., Cohen, S., Isselbacher, K.J., Walker, W.A. Gastroenterology (1981) [Pubmed]
  16. Expression of selectin ligands on murine effector and IL-10-producing CD4+ T cells from non-infected and infected tissues. Kretschmer, U., Bonhagen, K., Debes, G.F., Mittrücker, H.W., Erb, K.J., Liesenfeld, O., Zaiss, D., Kamradt, T., Syrbe, U., Hamann, A. Eur. J. Immunol. (2004) [Pubmed]
  17. Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during infection by the rat intestinal parasite Nippostrongylus brasiliensis. Karlsson, N.G., Olson, F.J., Jovall, P.A., Andersch, Y., Enerbäck, L., Hansson, G.C. Biochem. J. (2000) [Pubmed]
  18. Cysteine protease of the nematode Nippostrongylus brasiliensis preferentially evokes an IgE/IgG1 antibody response in rats. Kamata, I., Yamada, M., Uchikawa, R., Matsuda, S., Arizono, N. Clin. Exp. Immunol. (1995) [Pubmed]
  19. The Indian soft-furred rat, Millardia meltada, a new host for Nippostrongylus brasiliensis, showing androgen-dependent sex difference in intestinal mucosal defence. Tiuria, R., Horii, Y., Tateyama, S., Tsuchiya, K., Nawa, Y. Int. J. Parasitol. (1994) [Pubmed]
  20. Infection of Nippostrongylus brasiliensis induces normal increase of basophils in mast cell-deficient Ws/Ws rats with a small deletion at the kinase domain of c-kit. Kasugai, T., Okada, M., Morimoto, M., Arizono, N., Maeyama, K., Yamada, M., Tei, H., Dohmae, K., Onoue, H., Newlands, G.F. Blood (1993) [Pubmed]
  21. Lymphocytes bearing Fc receptors for IgE. VI. Suppressive effect of glucocorticoids on the expression of Fc epsilon receptors and glycosylation of IgE-binding factors. Yodoi, J., Hirashima, M., Ishizaka, K. J. Immunol. (1981) [Pubmed]
  22. Murine follicular dendritic cells and low affinity Fc receptors for IgE (Fc epsilon RII). Maeda, K., Burton, G.F., Padgett, D.A., Conrad, D.H., Huff, T.F., Masuda, A., Szakal, A.K., Tew, J.G. J. Immunol. (1992) [Pubmed]
  23. Antigenic challenge of immunized mice induces endogeneous production of IL-3 that increases histamine synthesis in hematopoietic organs. Lebel, B., Schneider, E., Piquet-Pellorce, C., Machavoine, F., Kindler, V., Luffau, G., Dy, M. J. Immunol. (1990) [Pubmed]
  24. Effect of nedocromil sodium on the compound exocytosis of mast cells. Enerbäck, L., Bergström, S. Drugs (1989) [Pubmed]
  25. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. Hoshino, K., Kashiwamura, S., Kuribayashi, K., Kodama, T., Tsujimura, T., Nakanishi, K., Matsuyama, T., Takeda, K., Akira, S. J. Exp. Med. (1999) [Pubmed]
  26. Macrophage engulfment of mucosal mast cells in rats treated with dexamethasone. Soda, K., Kawabori, S., Perdue, M.H., Bienenstock, J. Gastroenterology (1991) [Pubmed]
  27. Intestinal mucosal mast cells from rats infected with Nippostrongylus brasiliensis contain protease-resistant chondroitin sulfate di-B proteoglycans. Stevens, R.L., Lee, T.D., Seldin, D.C., Austen, K.F., Befus, A.D., Bienenstock, J. J. Immunol. (1986) [Pubmed]
  28. Nippostrongylus brasiliensis infection in the rat: effect of iron and protein deficiency on the anthelmintic efficacy of mebendazole, pyrantel, piperazine, and levamisole. Duncombe, V.M., Bolin, T.D., Davis, A.E., Fagan, M.R., Kelly, J.D. Gut (1979) [Pubmed]
  29. Nerve growth factor enhances antigen and other secretagogue-induced histamine release from rat peritoneal mast cells in the absence of phosphatidylserine. Tomioka, M., Stead, R.H., Nielsen, L., Coughlin, M.D., Bienenstock, J. J. Allergy Clin. Immunol. (1988) [Pubmed]
  30. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Yoshimoto, T., Okamura, H., Tagawa, Y.I., Iwakura, Y., Nakanishi, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  31. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Noben-Trauth, N., Shultz, L.D., Brombacher, F., Urban, J.F., Gu, H., Paul, W.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  32. Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. Sarafi, M.N., Garcia-Zepeda, E.A., MacLean, J.A., Charo, I.F., Luster, A.D. J. Exp. Med. (1997) [Pubmed]
  33. Mice deficient in CD23 reveal its modulatory role in IgE production but no role in T and B cell development. Stief, A., Texido, G., Sansig, G., Eibel, H., Le Gros, G., van der Putten, H. J. Immunol. (1994) [Pubmed]
  34. Development of IgE-forming cells in vitro from rat mesenteric lymph node cells. Suemura, M., Urban, J.F., Ishizaka, K. J. Immunol. (1978) [Pubmed]
  35. Kinetics of 4-aminobutyrate:2-oxoglutarate aminotransferase from Nippostrongylus brasiliensis. Watts, S.D., Atkins, A.M. Mol. Biochem. Parasitol. (1984) [Pubmed]
  36. Fluctuations in rat liver alanine-amino-transferase activity during experimental nippostrongylosis. Robertson, L.J. Parasitology (1989) [Pubmed]
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