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Gene Review

GNAI2  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: Adenylate cyclase-inhibiting G alpha protein, GIP, GNAI2B, Guanine nucleotide-binding protein G(i) subunit alpha-2, H_LUCA15.1, ...
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Disease relevance of GNAI2


High impact information on GNAI2


Chemical compound and disease context of GNAI2

  • Following diet and weight-reduction there was a significant decrease in both fasting and post-prandial insulin levels in the obese subjects but there were no significant changes in glucose or GIP concentrations [8].

Biological context of GNAI2


Anatomical context of GNAI2


Associations of GNAI2 with chemical compounds

  • Compensation index, potentiation, and sensitivity to GIP were interrelated parameters (P < 0.05 or less). beta-Cell function parameters were also related to mean 24-h glucose levels (r2 = 0.63, P < 0.0001, multivariate model) [15].
  • CONCLUSION: The close correlation between the use of pyrazinamide as measured by the GIP and NTR provides strong evidence that in the Netherlands tuberculosis is reported in conformity with the guidelines for notifiable diseases [16].
  • The majority of cases of GIP are caused by exposure to cobalt, tungsten and other hard metals [14].

Other interactions of GNAI2

  • Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13 [9].
  • Screening of the MEN 1 gene and genetic analysis of the hot spot regions of the GNAS 1 (codons 201 and 227) and GNAI 2 (codons 179 and 205) genes did not show any mutations in the constitutional DNA or the adrenal tissue DNA of the index patient [17].

Analytical, diagnostic and therapeutic context of GNAI2

  • Fasting GIP concentrations were similar, but postprandial levels were significantly greater in the obese subjects during both the OGTT and MTT [8].


  1. The -318 C>G single-nucleotide polymorphism in GNAI2 gene promoter region impairs transcriptional activity through specific binding of Sp1 transcription factor and is associated with high blood pressure in Caucasians from Italy. Menzaghi, C., Paroni, G., De Bonis, C., Soccio, T., Marucci, A., Bacci, S., Trischitta, V. J. Am. Soc. Nephrol. (2006) [Pubmed]
  2. Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin. Roche, J., Boldog, F., Robinson, M., Robinson, L., Varella-Garcia, M., Swanton, M., Waggoner, B., Fishel, R., Franklin, W., Gemmill, R., Drabkin, H. Oncogene (1996) [Pubmed]
  3. Absence of GNAI2 codon 179 oncogene mutations in inflammatory bowel disease. Zhang, W.J., Koltun, W.A., Tilberg, A.F., Page, M.J., Chorney, M.J. Inflamm. Bowel Dis. (2000) [Pubmed]
  4. ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications. Lieberman, S.A., Eccleshall, T.R., Feldman, D. Eur. J. Endocrinol. (1994) [Pubmed]
  5. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Sekido, Y., Bader, S., Latif, F., Chen, J.Y., Duh, F.M., Wei, M.H., Albanesi, J.P., Lee, C.C., Lerman, M.I., Minna, J.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Blatt, C., Eversole-Cire, P., Cohn, V.H., Zollman, S., Fournier, R.E., Mohandas, L.T., Nesbitt, M., Lugo, T., Jones, D.T., Reed, R.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  7. Isolation and characterization of sixteen novel p53 response genes. Kostic, C., Shaw, P.H. Oncogene (2000) [Pubmed]
  8. Obesity is associated with increased post-prandial GIP levels which are not reduced by dietary restriction and weight loss. Jones, I.R., Owens, D.R., Luzio, S.D., Hayes, T.M. Diabète & métabolisme. (1989) [Pubmed]
  9. Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. Magovcevic, I., Ang, S.L., Seidman, J.G., Tolman, C.J., Neer, E.J., Morton, C.C. Genomics (1992) [Pubmed]
  10. G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome. Sarwal, M.M., Sontag, J.M., Hoang, L., Brenner, S., Wilkie, T.M. Genome Res. (1996) [Pubmed]
  11. Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription. Fehmann, H.C., Göke, B. Peptides (1995) [Pubmed]
  12. Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining. Yeung, C.M., Wong, C.K., Chung, S.K., Chung, S.S., Chow, B.K. Mol. Cell. Endocrinol. (1999) [Pubmed]
  13. Are granulocyte inhibitory proteins contributing to enhanced susceptibility to infections in uraemia? Haag-Weber, M., Hörl, W.H. Nephrol. Dial. Transplant. (1996) [Pubmed]
  14. Giant-cell interstitial pneumonia in a gas station worker. Lee, S.M., Moon, C.H., Oh, Y.B., Kim, H.Y., Ahn, Y., Ko, E.J., Joo, J.E. J. Korean Med. Sci. (1998) [Pubmed]
  15. Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests. Mari, A., Gastaldelli, A., Natali, A., Ostergard, T., Schmitz, O., Ferrannini, E. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  16. Pyrazinamide use as a method of estimating under-reporting of tuberculosis. van Loenhout-Rooyackers, J.H., Leufkens, H.G., Hekster, Y.A., Kalisvaart, N.A. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2001) [Pubmed]
  17. Familial ACTH-independent Cushing's syndrome with bilateral macronodular adrenal hyperplasia clinically affecting only female family members. Nies, C., Bartsch, D.K., Ehlenz, K., Wild, A., Langer, P., Fleischhacker, S., Rothmund, M. Exp. Clin. Endocrinol. Diabetes (2002) [Pubmed]
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