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Gene Review

Meox2  -  mesenchyme homeobox 2

Mus musculus

Synonyms: AI528662, Gax, Homeobox protein MOX-2, Mesenchyme homeobox 2, Mox-2, ...
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Disease relevance of Meox2


High impact information on Meox2


Biological context of Meox2


Anatomical context of Meox2

  • Our results demonstrate that Meox1 and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites [5].
  • In the skeletal muscle lineage, Gax protein was expressed at the onset of somitogenesis before the expression of the myogenic basic helix-loop-helix and MEF2/RSRF family proteins [8].
  • Gax in the cardiac muscle lineage exhibited a biphasic pattern of expression [8].
  • Gax expression was also noted in smooth muscle cells as early as day 9.5 pc [8].
  • Gax is a homeobox-containing gene that has been detected in adult cardiovascular tissues and exhibits a growth arrest-specific pattern of expression in cultured vascular myocytes [8].

Associations of Meox2 with chemical compounds


Other interactions of Meox2


Analytical, diagnostic and therapeutic context of Meox2

  • Further analysis revealed that Gax down-regulated numerous nuclear factor-kappaB (NF-kappaB) target genes and decreased the binding of NF-kappaB to its target sequence in electrophoretic mobility shift assays [2].


  1. Analysis of Meox-2 mutant mice reveals a novel postfusion-based cleft palate. Jin, J.Z., Ding, J. Dev. Dyn. (2006) [Pubmed]
  2. The homeobox gene Gax inhibits angiogenesis through inhibition of nuclear factor-kappaB-dependent endothelial cell gene expression. Patel, S., Leal, A.D., Gorski, D.H. Cancer Res. (2005) [Pubmed]
  3. Mox2 is a component of the genetic hierarchy controlling limb muscle development. Mankoo, B.S., Collins, N.S., Ashby, P., Grigorieva, E., Pevny, L.H., Candia, A., Wright, C.V., Rigby, P.W., Pachnis, V. Nature (1999) [Pubmed]
  4. Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity. Perlman, H., Sata, M., Le Roux, A., Sedlak, T.W., Branellec, D., Walsh, K. EMBO J. (1998) [Pubmed]
  5. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Mankoo, B.S., Skuntz, S., Harrigan, I., Grigorieva, E., Candia, A., Wright, C.V., Arnheiter, H., Pachnis, V. Development (2003) [Pubmed]
  6. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Candia, A.F., Hu, J., Crosby, J., Lalley, P.A., Noden, D., Nadeau, J.H., Wright, C.V. Development (1992) [Pubmed]
  7. Whole genomewide linkage screen for neural tube defects reveals regions of interest on chromosomes 7 and 10. Rampersaud, E., Bassuk, A.G., Enterline, D.S., George, T.M., Siegel, D.G., Melvin, E.C., Aben, J., Allen, J., Aylsworth, A., Brei, T., Bodurtha, J., Buran, C., Floyd, L.E., Hammock, P., Iskandar, B., Ito, J., Kessler, J.A., Lasarsky, N., Mack, P., Mackey, J., McLone, D., Meeropol, E., Mehltretter, L., Mitchell, L.E., Oakes, W.J., Nye, J.S., Powell, C., Sawin, K., Stevenson, R., Walker, M., West, S.G., Worley, G., Gilbert, J.R., Speer, M.C. J. Med. Genet. (2005) [Pubmed]
  8. Embryonic expression of the Gax homeodomain protein in cardiac, smooth, and skeletal muscle. Skopicki, H.A., Lyons, G.E., Schatteman, G., Smith, R.C., Andrés, V., Schirm, S., Isner, J., Walsh, K. Circ. Res. (1997) [Pubmed]
  9. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. Grigoriou, M., Kastrinaki, M.C., Modi, W.S., Theodorakis, K., Mankoo, B., Pachnis, V., Karagogeos, D. Genomics (1995) [Pubmed]
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