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Gene Review

Cebpb  -  CCAAT/enhancer binding protein (C/EBP), beta

Rattus norvegicus

Synonyms: C/EBP beta, C/EBP-related protein 2, CCAAT/enhancer-binding protein beta, Crp2, IL-6DBP, ...
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Disease relevance of Cebpb


High impact information on Cebpb


Biological context of Cebpb


Anatomical context of Cebpb


Associations of Cebpb with chemical compounds


Regulatory relationships of Cebpb

  • Altogether, these results demonstrated that infection of glial cells by JEV provided the early ERK-, NF-kappaB-, and NF-IL-6-mediated signals that directly activated RANTES expression, which might be involved in the initiation and amplification of inflammatory responses in the CNS [13].

Other interactions of Cebpb


Analytical, diagnostic and therapeutic context of Cebpb


  1. LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation. Buck, M., Turler, H., Chojkier, M. EMBO J. (1994) [Pubmed]
  2. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-kappa B and NF-IL6 in cardiac myocytes. Matsui, H., Ihara, Y., Fujio, Y., Kunisada, K., Akira, S., Kishimoto, T., Yamauchi-Takihara, K. Cardiovasc. Res. (1999) [Pubmed]
  3. Transcription factors modulating angiotensinogen gene expression in hepatocytes. Brasier, A.R., Li, J., Copland, A. Kidney Int. (1994) [Pubmed]
  4. Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Wuarin, J., Schibler, U. Cell (1990) [Pubmed]
  5. The consolidation of new but not reactivated memory requires hippocampal C/EBPbeta. Taubenfeld, S.M., Milekic, M.H., Monti, B., Alberini, C.M. Nat. Neurosci. (2001) [Pubmed]
  6. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. Trautwein, C., van der Geer, P., Karin, M., Hunter, T., Chojkier, M. J. Clin. Invest. (1994) [Pubmed]
  7. Functional cooperation between CCAAT/enhancer-binding proteins and the vitamin D receptor in regulation of 25-hydroxyvitamin D3 24-hydroxylase. Dhawan, P., Peng, X., Sutton, A.L., MacDonald, P.N., Croniger, C.M., Trautwein, C., Centrella, M., McCarthy, T.L., Christakos, S. Mol. Cell. Biol. (2005) [Pubmed]
  8. AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor. Boruk, M., Savory, J.G., Haché, R.J. Mol. Endocrinol. (1998) [Pubmed]
  9. Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells. Billack, B., Heck, D.E., Mariano, T.M., Gardner, C.R., Sur, R., Laskin, D.L., Laskin, J.D. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  10. Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. Walpen, S., Beck, K.F., Schaefer, L., Raslik, I., Eberhardt, W., Schaefer, R.M., Pfeilschifter, J. FASEB J. (2001) [Pubmed]
  11. Transcriptional regulation of the mouse angiotensin II type 2 receptor gene. Ichiki, T., Inagami, T. Hypertension (1995) [Pubmed]
  12. Downregulation of the CCAAT-enhancer binding protein beta in deltaFosB transgenic mice and by electroconvulsive seizures. Chen, J., Newton, S.S., Zeng, L., Adams, D.H., Dow, A.L., Madsen, T.M., Nestler, E.J., Duman, R.S. Neuropsychopharmacology (2004) [Pubmed]
  13. Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. Chen, C.J., Chen, J.H., Chen, S.Y., Liao, S.L., Raung, S.L. J. Virol. (2004) [Pubmed]
  14. Inhibition of inducible nitric oxide synthase expression by baicalein in endotoxin/cytokine-stimulated microglia. Chen, C.J., Raung, S.L., Liao, S.L., Chen, S.Y. Biochem. Pharmacol. (2004) [Pubmed]
  15. Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3. Zhao, X., Zhuang, S., Chen, Y., Boss, G.R., Pilz, R.B. J. Biol. Chem. (2005) [Pubmed]
  16. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction. Nishio, Y., Isshiki, H., Kishimoto, T., Akira, S. Mol. Cell. Biol. (1993) [Pubmed]
  17. Induction of cytokine-induced neutrophil chemoattractant in response to various stresses in rat C6 glioma cells. Uehara, T., Baba, I., Nomura, Y. Brain Res. (1998) [Pubmed]
  18. SF-B that binds to a negative element in glutathione transferase P gene is similar or identical to trans-activator LAP/IL6-DBP. Imagawa, M., Osada, S., Koyama, Y., Suzuki, T., Hirom, P.C., Diccianni, M.B., Morimura, S., Muramatsu, M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  19. The cardioprotective agent urocortin induces expression of CT-1. Janjua, S., Lawrence, K.M., Ng, L.L., Latchman, D.S. Cardiovasc. Toxicol. (2003) [Pubmed]
  20. Regulated expression of alpha 2,6-sialyltransferase by the liver-enriched transcription factors HNF-1, DBP, and LAP. Svensson, E.C., Conley, P.B., Paulson, J.C. J. Biol. Chem. (1992) [Pubmed]
  21. Down-regulation by cAMP of angiotensin II type 2 receptor gene expression in PC12 cells. Murasawa, S., Matsubara, H., Kijima, K., Maruyama, K., Ohkubo, N., Mori, Y., Iwasaka, T., Inada, M. Hypertens. Res. (1996) [Pubmed]
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