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Gene Review

Cyp21a1  -  cytochrome P450, family 21, subfamily a,...

Rattus norvegicus

Synonyms: 21-OH, 21-OHase, Cyp21, Cytochrome P-450c21, Cytochrome P450 21, ...
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Disease relevance of Cyp21a1

  • Hyperprolactinemia did not influence microsomal 3B-HSD or mitochondrial 11-OHase activities but was associated with a dose dependent decrease in microsomal 21-OHase activity when compared to controls (p less than 0.001) [1].

High impact information on Cyp21a1


Chemical compound and disease context of Cyp21a1


Anatomical context of Cyp21a1


Associations of Cyp21a1 with chemical compounds

  • However, different from human and mouse, a copy of the C4, Cyp21, and Stk19 genes is found that maps to the class II region in the rat [7].
  • Dog PBD-2 metabolizes progesterone primarily to the 21-OH metabolite, while metabolism by rat PB-B leads to the formation of the 16 alpha-OH product [8].
  • Rat adrenal 3 beta-hydroxysteroid dehydrogenase/isomerase (3-HSD), 21-hydroxylase (21-OH) and 11-hydroxylase (11-OH) activities decreased with increasing RU486 doses, with 21-OH and 11-OH being most severely affected [9].
  • High local activity with no side effects, equivalent to that of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon), is obtained when either the 17- or 21-OH of halopredone are benzoylated [10].

Physical interactions of Cyp21a1


Other interactions of Cyp21a1


Analytical, diagnostic and therapeutic context of Cyp21a1


  1. New evidence for a direct effect of prolactin on rat adrenal steroidogenesis. Albertson, B.D., Sienkiewicz, M.L., Kimball, D., Munabi, A.K., Cassorla, F., Loriaux, D.L. Endocr. Res. (1987) [Pubmed]
  2. The acute and chronic effects of adrenocorticotropin on the levels of messenger ribonucleic acid and protein of steroidogenic enzymes in rat adrenal in vivo. Lehoux, J.G., Fleury, A., Ducharme, L. Endocrinology (1998) [Pubmed]
  3. Alteration in the expression of genes for cholesterol side-chain cleavage enzyme and 21-hydroxylase by hypophysectomy and ACTH administration in the rat adrenal. Imai, T., Seo, H., Murata, Y., Ohno, M., Satoh, Y., Funahashi, H., Takagi, H., Matsui, N. J. Mol. Endocrinol. (1990) [Pubmed]
  4. Organ-specific properties of cytochromes P-450s21 (steroid 21-hydroxylases) of liver and adrenocortical microsomes. Ichikawa, Y., Hiwatashi, A., Tsubaki, M. FEBS Lett. (1984) [Pubmed]
  5. Steroid 21-hydroxylase expression in cultured rat astrocytes. Lovelace, M., Watson, T.G., Stephenson, G.L. Brain Res. Bull. (2003) [Pubmed]
  6. Biphasic regulation by N6,2'-O-dibutyryl adenosine 3',5'-cyclic monophosphate (dbcAMP) of steroid 21-hydroxylase activity in rat hepatocytes. Nasuda, K., Endoh, A., Igarashi, Y. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
  7. Physical mapping of the major histocompatibility complex class II and class III regions of the rat. Walter, L., Hurt, P., Himmelbauer, H., Sudbrak, R., Günther, E. Immunogenetics (2002) [Pubmed]
  8. The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2. Duignan, D.B., Sipes, I.G., Ciaccio, P.J., Halpert, J.R. Arch. Biochem. Biophys. (1988) [Pubmed]
  9. Effect of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis. Albertson, B.D., Hill, R.B., Sprague, K.A., Wood, K.E., Nieman, L.K., Loriaux, D.L. Eur. J. Endocrinol. (1994) [Pubmed]
  10. New esters of Halopredone for topical antiinflammatory use. Toscano, L., Grisanti, G., Bianchetti, A., Bossoni, G. Arzneimittel-Forschung. (1977) [Pubmed]
  11. The effect of Sutherlandia frutescens on steroidogenesis: confirming indigenous wisdom. Prevoo, D., Smith, C., Swart, P., Swart, A.C. Endocr. Res. (2004) [Pubmed]
  12. Levels of adrenodoxin, NADPH-cytochrome P-450 reductase and cytochromes P-45011 beta, P-45021, P-450scc, in adrenal zona fasciculata-reticularis tissue from androgen-treated rats. Brownie, A.C., Bhasker, C.R., Waterman, M.R. Mol. Cell. Endocrinol. (1988) [Pubmed]
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