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Gene Review

Cyp21a1  -  cytochrome P450, family 21, subfamily a,...

Mus musculus

Synonyms: 21-OH, 21-OHase, 21-hydroxylase, 21OH, 21OHA, ...
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Disease relevance of Cyp21a1


High impact information on Cyp21a1

  • We found that there are two 21-OH genes in this region, located immediately 3' to the C4 and Slp genes [5].
  • To determine whether 21-OH genes are located in the H-2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse [5].
  • DNA fragments encoding the mouse steroid 21-hydroxylase (C21 or Cyp21A1) gene are de novo methylated when introduced into the mouse adrenocortical tumor cell line Y1 by DNA-mediated gene transfer [6].
  • Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination [7].
  • All data that were obtained supported the hypothesis that the meiotic, presumably unequal, recombination between homologous chromosomes of the H-2a and H-2wm7 haplotypes caused the deletion of the C4 and the 21-hydroxylase genes [7].

Chemical compound and disease context of Cyp21a1

  • Collectively, results of these investigations suggest that esterification of 21-OH with various anhydrides did not improve receptor binding, inhibition of NO generation and ear edema inhibition, however, serum corticosterone level and local over systemic activities (L/S) were markedly improved [8].

Biological context of Cyp21a1


Anatomical context of Cyp21a1


Associations of Cyp21a1 with chemical compounds


Physical interactions of Cyp21a1


Regulatory relationships of Cyp21a1


Other interactions of Cyp21a1


Analytical, diagnostic and therapeutic context of Cyp21a1


  1. The murine Slp gene. Additional evidence that sex-limited protein has no biologic function. Ogata, R.T., Zepf, N.E. J. Immunol. (1991) [Pubmed]
  2. Adrenomedullary function is severely impaired in 21-hydroxylase-deficient mice. Bornstein, S.R., Tajima, T., Eisenhofer, G., Haidan, A., Aguilera, G. FASEB J. (1999) [Pubmed]
  3. Restoration of adrenal steroidogenesis by adenovirus-mediated transfer of human cytochromeP450 21-hydroxylase into the adrenal gland of21-hydroxylase-deficient mice. Tajima, T., Okada, T., Ma, X.M., Ramsey, W., Bornstein, S., Aguilera, G. Gene Ther. (1999) [Pubmed]
  4. Analysis of autoantibody epitopes on steroid 21-hydroxylase using a panel of monoclonal antibodies. Chen, S., Sawicka, J., Prentice, L., Sanders, J.F., Tanaka, H., Petersen, V., Betterle, C., Volpato, M., Roberts, S., Powell, M., Smith, B.R., Furmaniak, J. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  5. Two steroid 21-hydroxylase genes are located in the murine S region. White, P.C., Chaplin, D.D., Weis, J.H., Dupont, B., New, M.I., Seidman, J.G. Nature (1984) [Pubmed]
  6. Nucleotide-sequence-specific de novo methylation in a somatic murine cell line. Szyf, M., Schimmer, B.P., Seidman, J.G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination. Shiroishi, T., Sagai, T., Natsuume-Sakai, S., Moriwaki, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  8. New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives. Ko, D.H., Heiman, A.S., Hudson, C.E., Lee, H.J. Steroids (2002) [Pubmed]
  9. Congenital adrenal hyperplasia: the molecular basis of 21-hydroxylase deficiency in H-2(aw18) mice. Riepe, F.G., Tatzel, S., Sippell, W.G., Pleiss, J., Krone, N. Endocrinology (2005) [Pubmed]
  10. Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Heikkilä, M., Peltoketo, H., Leppäluoto, J., Ilves, M., Vuolteenaho, O., Vainio, S. Endocrinology (2002) [Pubmed]
  11. Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression. Chaplin, D.D., Galbraith, L.J., Seidman, J.G., White, P.C., Parker, K.L. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. Pazirandeh, A., Xue, Y., Rafter, I., Sjövall, J., Jondal, M., Okret, S. FASEB J. (1999) [Pubmed]
  13. Steroidogenic adrenocortical cell lines produced by genetically targeted tumorigenesis in transgenic mice. Mellon, S.H., Miller, W.L., Bair, S.R., Moore, C.C., Vigne, J.L., Weiner, R.I. Mol. Endocrinol. (1994) [Pubmed]
  14. The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene. Yu, C.Y. J. Immunol. (1991) [Pubmed]
  15. Prenatal dexamethasone treatment does not prevent alterations of the hypothalamic pituitary adrenal axis in steroid 21-hydroxylase deficient mice. Tajima, T., Ma, X.M., Bornstein, S.R., Aguilera, G. Endocrinology (1999) [Pubmed]
  16. The transcription of the human fructose-bisphosphate aldolase C gene is activated by nerve-growth-factor-induced B factor in human neuroblastoma cells. Buono, P., Conciliis, L.D., Izzo, P., Salvatore, F. Biochem. J. (1997) [Pubmed]
  17. Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes. Mukai, K., Nagasawa, H., Agake-Suzuki, R., Mitani, F., Totani, K., Yanai, N., Obinata, M., Suematsu, M., Ishimura, Y. Eur. J. Biochem. (2002) [Pubmed]
  18. The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid 21-hydroxylase. Wilson, T.E., Mouw, A.R., Weaver, C.A., Milbrandt, J., Parker, K.L. Mol. Cell. Biol. (1993) [Pubmed]
  19. Adrenocortical function and regulation of the steroid 21-hydroxylase gene in NGFI-B-deficient mice. Crawford, P.A., Sadovsky, Y., Woodson, K., Lee, S.L., Milbrandt, J. Mol. Cell. Biol. (1995) [Pubmed]
  20. Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1. Hu, M.C., Hsu, N.C., El Hadj, N.B., Pai, C.I., Chu, H.P., Wang, C.K., Chung, B.C. Mol. Endocrinol. (2002) [Pubmed]
  21. Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Ikeda, Y., Lala, D.S., Luo, X., Kim, E., Moisan, M.P., Parker, K.L. Mol. Endocrinol. (1993) [Pubmed]
  22. Identification of promoter elements in the mouse 21-hydroxylase (Cyp21) gene that require a functional cyclic adenosine 3',5'-monophosphate-dependent protein kinase. Parissenti, A.M., Parker, K.L., Schimmer, B.P. Mol. Endocrinol. (1993) [Pubmed]
  23. Survival of steroid 21-hydroxylase-deficient mice without endogenous corticosteroids after neonatal treatment and genetic rescue by transgenesis as a model system for treatment of congenital adrenal hyperplasia in humans. Gotoh, H., Kusakabe, M., Shiroishi, T., Moriwaki, K. Endocrinology (1994) [Pubmed]
  24. Characterization of a regulatory region of the steroid 21-hydroxylase gene. Parker, K.L., Schimmer, B.P., Chaplin, D.D., Seidman, J.G. J. Biol. Chem. (1986) [Pubmed]
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