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Gene Review

ANXA8L2  -  annexin A8-like 2

Homo sapiens

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Disease relevance of ANXA8


High impact information on ANXA8


Biological context of ANXA8


Anatomical context of ANXA8


Associations of ANXA8 with chemical compounds

  • In the present investigation, we showed using the APL-derived NB4 cell line that expression of the annexin VIII gene is regulated at the transcription level during induced differentiation by all-trans retinoic acid (ATRA) [1].
  • Treatment of NB-4 cells with all-trans retinoic acid (ATRA) or the phorbol ester TPA induced terminal differentiation and down-regulated annexin VIII mRNA expression rapidly within a few hours; vitamin D3 was ineffective in this regard; the protein kinase C activator Bryostatin 1 up-regulated the expression [4].

Regulatory relationships of ANXA8


Other interactions of ANXA8


Analytical, diagnostic and therapeutic context of ANXA8


  1. Regulation of the expression of annexin VIII in acute promyelocytic leukemia. Sarkar, A., Yang, P., Fan, Y.H., Mu, Z.M., Hauptmann, R., Adolf, G.R., Stass, S.A., Chang, K.S. Blood (1994) [Pubmed]
  2. Specific expression of the annexin VIII gene in acute promyelocytic leukemia. Chang, K.S., Wang, G., Freireich, E.J., Daly, M., Naylor, S.L., Trujillo, J.M., Stass, S.A. Blood (1992) [Pubmed]
  3. Annexin A8 displays unique phospholipid and F-actin binding properties. Goebeler, V., Ruhe, D., Gerke, V., Rescher, U. FEBS Lett. (2006) [Pubmed]
  4. Expression and modulation of annexin VIII in human leukemia-lymphoma cell lines. Hu, Z.B., Ma, W., Uphoff, C.C., Drexler, H.G. Leuk. Res. (1993) [Pubmed]
  5. Expression of the annexin VIII gene in acute promyelocytic leukemia. Liu, J.H., Stass, S.A., Chang, K.S. Leuk. Lymphoma (1994) [Pubmed]
  6. Two candidate downstream target genes for E2A-HLF. Kurosawa, H., Goi, K., Inukai, T., Inaba, T., Chang, K.S., Shinjyo, T., Rakestraw, K.M., Naeve, C.W., Look, A.T. Blood (1999) [Pubmed]
  7. Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. Hauptmann, R., Maurer-Fogy, I., Krystek, E., Bodo, G., Andree, H., Reutelingsperger, C.P. Eur. J. Biochem. (1989) [Pubmed]
  8. A 42-kilodalton annexin-like protein is associated with plant vacuoles. Seals, D.F., Parrish, M.L., Randall, S.K. Plant Physiol. (1994) [Pubmed]
  9. Specific expression of annexin A8 in adult murine stratified epithelia. Runkel, F., Michels, M., Franken, S., Franz, T. J. Mol. Histol. (2006) [Pubmed]
  10. Differential tissue expression of Annexin VIII in human. Reutelingsperger, C.P., van Heerde, W., Hauptmann, R., Maassen, C., van Gool, R.G., de Leeuw, P., Tiebosch, A. FEBS Lett. (1994) [Pubmed]
  11. Molecular characterization of adenocarcinoma and squamous carcinoma of the uterine cervix using microarray analysis of gene expression. Chao, A., Wang, T.H., Lee, Y.S., Hsueh, S., Chao, A.S., Chang, T.C., Kung, W.H., Huang, S.L., Chao, F.Y., Wei, M.L., Lai, C.H. Int. J. Cancer (2006) [Pubmed]
  12. The crystal structure of annexin A8 is similar to that of annexin A3. Réty, S., Sopková-de Oliveira Santos, J., Dreyfuss, L., Blondeau, K., Hofbauerová, K., Raguénès-Nicol, C., Kerboeuf, D., Renouard, M., Russo-Marie, F., Lewit-Bentley, A. J. Mol. Biol. (2005) [Pubmed]
  13. Detection of VAC-beta (annexin-8) in human placenta. Pepinsky, R.B., Hauptmann, R. FEBS Lett. (1992) [Pubmed]
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