Gene Review:
Bcl2l11 - BCL2-like 11 (apoptosis facilitator)
Rattus norvegicus
Synonyms:
Bcl-2-like protein 11, Bcl-2-related ovarian death protein, Bcl2-L-11, Bcl2-interacting mediator of cell death, Bim, ...
- The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia. Okuno, S., Saito, A., Hayashi, T., Chan, P.H. J. Neurosci. (2004)
- Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. Meller, R., Cameron, J.A., Torrey, D.J., Clayton, C.E., Ordonez, A.N., Henshall, D.C., Minami, M., Schindler, C.K., Saugstad, J.A., Simon, R.P. J. Biol. Chem. (2006)
- Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy. Shinoda, S., Schindler, C.K., Meller, R., So, N.K., Araki, T., Yamamoto, A., Lan, J.Q., Taki, W., Simon, R.P., Henshall, D.C. J. Clin. Invest. (2004)
- During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria. Kim, P.K., Annis, M.G., Dlugosz, P.J., Leber, B., Andrews, D.W. Mol. Cell (2004)
- Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. Wilson-Annan, J., O'Reilly, L.A., Crawford, S.A., Hausmann, G., Beaumont, J.G., Parma, L.P., Chen, L., Lackmann, M., Lithgow, T., Hinds, M.G., Day, C.L., Adams, J.M., Huang, D.C. J. Cell Biol. (2003)
- Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function. Qi, X.J., Wildey, G.M., Howe, P.H. J. Biol. Chem. (2006)
- Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. Le, S.S., Loucks, F.A., Udo, H., Richardson-Burns, S., Phelps, R.A., Bouchard, R.J., Barth, H., Aktories, K., Tyler, K.L., Kandel, E.R., Heidenreich, K.A., Linseman, D.A. J. Neurochem. (2005)
- Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. Biswas, S.C., Greene, L.A. J. Biol. Chem. (2002)
- Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. Biswas, S.C., Liu, D.X., Greene, L.A. J. Neurosci. (2005)
- Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain. Korhonen, L., Belluardo, N., Mudo, G., Lindholm, D. Eur. J. Neurosci. (2003)
- Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection. Näpänkangas, U., Lindqvist, N., Lindholm, D., Hallböök, F. Brain Res. Mol. Brain Res. (2003)
- Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Leinninger, G.M., Backus, C., Sastry, A.M., Yi, Y.B., Wang, C.W., Feldman, E.L. Neurobiol. Dis. (2006)
- Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors. Butts, B.D., Hudson, H.R., Linseman, D.A., Le, S.S., Ryan, K.R., Bouchard, R.J., Heidenreich, K.A. Mol. Cell. Neurosci. (2005)
- Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. Loucks, F.A., Le, S.S., Zimmermann, A.K., Ryan, K.R., Barth, H., Aktories, K., Linseman, D.A. J. Neurochem. (2006)
- Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim. Zimmermann, A.K., Loucks, F.A., Le, S.S., Butts, B.D., Florez-McClure, M.L., Bouchard, R.J., Heidenreich, K.A., Linseman, D.A. J. Neurochem. (2005)
- Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Lajoix, A.D., Gross, R., Aknin, C., Dietz, S., Granier, C., Laune, D. Mol. Divers. (2004)
- Toxicogenomic studies of the rat brain at an early time point following acute sarin exposure. Damodaran, T.V., Greenfield, S.T., Patel, A.G., Dressman, H.K., Lin, S.K., Abou-Donia, M.B. Neurochem. Res. (2006)
- Identification of JNK-dependent and -independent components of cerebellar granule neuron apoptosis. Harris, C., Maroney, A.C., Johnson, E.M. J. Neurochem. (2002)
- JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury. Yin, K.J., Kim, G.M., Lee, J.M., He, Y.Y., Xu, J., Hsu, C.Y. Neurobiol. Dis. (2005)