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Gene Review

Omp  -  olfactory marker protein

Rattus norvegicus

Synonyms: Olfactory marker protein, Olfactory neuronal-specific protein
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Disease relevance of Omp


High impact information on Omp


Biological context of Omp

  • The library was constructed from olfactory mucosa poly(A)+ RNA enriched for OMP mRNA and cloned into a pBR322-derived plasmid, pMG5 [3].
  • Studies with transgenic mice indicate that a 0.3-kb fragment of the OMP gene containing one Olf-1 motif is sufficient for olfactory tissue-specific expression of the reporter gene [4].
  • We report characterization of several domains within the 5' flanking region of the olfactory marker protein (OMP) gene that may participate in regulating transcription of this and other olfactory neuron-specific genes [4].
  • The functional significance that these dynamic regions of OMP have in modulating olfactory signal transduction is discussed [5].
  • Dual color FISH analysis of tumor cells confirmed that chromosome regions containing Omp and Jak2 were amplified and were situated in long marker chromosomes showing an aberrant banding pattern [6].

Anatomical context of Omp


Associations of Omp with chemical compounds

  • In addition, the immunoprecipitated product comigrated with OMP on NaDodSO4/polyacrylamide gels and on HPLC [11].
  • In contrast to axonally transported vasopressin and oxytocin mRNAs, which are deficient in their 3' polyA tails, axonal OMP RNA fractionated as polyA+ [12].
  • Dopamine also stimulated differentiation of surviving 13.S.1.24 cells into bipolar olfactory marker protein-immunoreactive neurons [13].
  • GnRH was never co-localized with carnosine/OMP in the same migratory cells [14].
  • Among these cell types are the ensheathing cells, the luteinizing hormone-releasing hormone-producing cells and the olfactory marker protein-immunoreactive cells [15].

Physical interactions of Omp


Regulatory relationships of Omp


Other interactions of Omp


Analytical, diagnostic and therapeutic context of Omp


  1. Olfactory marker protein gene: its structure and olfactory neuron-specific expression in transgenic mice. Danciger, E., Mettling, C., Vidal, M., Morris, R., Margolis, F. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  2. Essential role of thyroid hormones in maturation of olfactory receptor neurons: an immunocytochemical study of number and cytoarchitecture of OMP-positive cells in developing rats. Paternostro, M.A., Meisami, E. Int. J. Dev. Neurosci. (1996) [Pubmed]
  3. Molecular cloning and sequencing of a cDNA for olfactory marker protein. Rogers, K.E., Dasgupta, P., Gubler, U., Grillo, M., Khew-Goodall, Y.S., Margolis, F.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Olf-1-binding site: characterization of an olfactory neuron-specific promoter motif. Kudrycki, K., Stein-Izsak, C., Behn, C., Grillo, M., Akeson, R., Margolis, F.L. Mol. Cell. Biol. (1993) [Pubmed]
  5. Backbone dynamics of the olfactory marker protein as studied by 15N NMR relaxation measurements. Gitti, R.K., Wright, N.T., Margolis, J.W., Varney, K.M., Weber, D.J., Margolis, F.L. Biochemistry (2005) [Pubmed]
  6. Analysis of chromosomal aberrations involving chromosome 1q31-->q53 in a DMBA-induced rat fibrosarcoma cell line: amplification and overexpression of Jak2. Sjöling, A., Lindholm, H., Samuelson, E., Yamasaki, Y., Watanabe, T.K., Tanigami, A., Levan, G. Cytogenet. Cell Genet. (2001) [Pubmed]
  7. Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons. Moriya-Ito, K., Osada, T., Ishimatsu, Y., Muramoto, K., Kobayashi, T., Ichikawa, M. Chem. Senses (2005) [Pubmed]
  8. The expression of the growth associated protein B50/GAP43 in the olfactory system of neonatal and adult rats. Verhaagen, J., Oestreicher, A.B., Gispen, W.H., Margolis, F.L. J. Neurosci. (1989) [Pubmed]
  9. Olfactory bulb increases marker protein in olfactory receptor cells. Chuah, M.I., Farbman, A.I. J. Neurosci. (1983) [Pubmed]
  10. Differentiation of neurons containing olfactory marker protein in adult rat olfactory epithelium transplanted to the anterior chamber of the eye. Barber, P.C., Jensen, S., Zimmer, J. Neuroscience (1982) [Pubmed]
  11. Olfactory neuron-specific protein is translated from a large poly(A)+ mRNA. Rogers, K.E., Grillo, M., Sydor, W., Poonian, M., Margolis, F.L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  12. Olfactory marker protein mRNA is found in axons of olfactory receptor neurons. Wensley, C.H., Stone, D.M., Baker, H., Kauer, J.S., Margolis, F.L., Chikaraishi, D.M. J. Neurosci. (1995) [Pubmed]
  13. In vitro induction of apoptosis or differentiation by dopamine in an immortalized olfactory neuronal cell line. Coronas, V., Féron, F., Hen, R., Sicard, G., Jourdan, F., Moyse, E. J. Neurochem. (1997) [Pubmed]
  14. Development and migration of olfactory neurones in the nervous system of the neonatal opossum. Tarozzo, G., Peretto, P., Biffo, S., Varga, Z., Nicholls, J.G., Fasolo, A. Proc. Biol. Sci. (1995) [Pubmed]
  15. The telencephalic vesicles are innervated by olfactory placode-derived cells: a possible mechanism to induce neocortical development. De Carlos, J.A., López-Mascaraque, L., Valverde, F. Neuroscience (1995) [Pubmed]
  16. Olfactory marker protein immunohistochemistry and the anterograde transport of horseradish peroxidase as indices of damage to the olfactory epithelium. Slotnick, B., Bodyak, N., Davis, B.J. Chem. Senses (2001) [Pubmed]
  17. Number of olfactory marker protein-containing receptor cells is influenced by developmental stage of the olfactory bulb. Chuah, M.I., Au, C. J. Neurosci. Res. (1988) [Pubmed]
  18. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Tsim, T.Y., Wong, E.Y., Leung, M.S., Wong, C.C. Neuroscience (2004) [Pubmed]
  19. Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb--II. Prominent differences in the intraglomerular dendritic arborization and their relationship to olfactory nerve terminals. Kosaka, K., Toida, K., Margolis, F.L., Kosaka, T. Neuroscience (1997) [Pubmed]
  20. TGF-alpha and olfactory marker protein enhance mitosis in rat olfactory epithelium in vivo. Farbman, A.I., Ezeh, P.I. Neuroreport (2000) [Pubmed]
  21. Spatiotemporal distribution of the insulin-like growth factor receptor in the rat olfactory bulb. Ferrari, C.C., Johnson, B.A., Leon, M., Pixley, S.K. Neurochem. Res. (2003) [Pubmed]
  22. Amino acid sequence of a unique neuronal protein: rat olfactory marker protein. Sydor, W., Teitelbaum, Z., Blacher, R., Sun, S., Benz, W., Margolis, F.L. Arch. Biochem. Biophys. (1986) [Pubmed]
  23. Differential distribution of the synapsins in the rat olfactory bulb. Stone, L.M., Browning, M.D., Finger, T.E. J. Neurosci. (1994) [Pubmed]
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