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Gene Review

Ptgds  -  prostaglandin D2 synthase (brain)

Rattus norvegicus

Synonyms: Glutathione-independent PGD synthase, Lipocalin-type prostaglandin-D synthase, PGD2 synthase, PGDS, PGDS2, ...
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Disease relevance of Ptgds


High impact information on Ptgds


Chemical compound and disease context of Ptgds


Biological context of Ptgds


Anatomical context of Ptgds


Associations of Ptgds with chemical compounds


Analytical, diagnostic and therapeutic context of Ptgds


  1. Prostaglandin D2 synthase inhibits the exaggerated growth phenotype of spontaneously hypertensive rat vascular smooth muscle cells. Ragolia, L., Palaia, T., Paric, E., Maesaka, J.K. J. Biol. Chem. (2003) [Pubmed]
  2. Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain. García-Fernández, L.F., Rausell, E., Urade, Y., Hayaishi, O., Bernal, J., Muñoz, A. Eur. J. Neurosci. (1997) [Pubmed]
  3. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. Beuckmann, C.T., Gordon, W.C., Kanaoka, Y., Eguchi, N., Marcheselli, V.L., Gerashchenko, D.Y., Urade, Y., Hayaishi, O., Bazan, N.G. J. Neurosci. (1996) [Pubmed]
  4. Regulation of lipocalin-type prostaglandin D synthase gene expression by Hes-1 through E-box and interleukin-1 beta via two NF-kappa B elements in rat leptomeningeal cells. Fujimori, K., Fujitani, Y., Kadoyama, K., Kumanogoh, H., Ishikawa, K., Urade, Y. J. Biol. Chem. (2003) [Pubmed]
  5. Structural basis of hematopoietic prostaglandin D synthase activity elucidated by site-directed mutagenesis. Pinzar, E., Miyano, M., Kanaoka, Y., Urade, Y., Hayaishi, O. J. Biol. Chem. (2000) [Pubmed]
  6. Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter. Tanaka, T., Urade, Y., Kimura, H., Eguchi, N., Nishikawa, A., Hayaishi, O. J. Biol. Chem. (1997) [Pubmed]
  7. Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. García-Fernández, L.F., Urade, Y., Hayaishi, O., Bernal, J., Muñoz, A. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  8. Inhibition of cell cycle progression and migration of vascular smooth muscle cells by prostaglandin D2 synthase: resistance in diabetic Goto-Kakizaki rats. Ragolia, L., Palaia, T., Koutrouby, T.B., Maesaka, J.K. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  9. Prostaglandin D2 synthase induces apoptosis in PC12 neuronal cells. Ragolia, L., Palaia, T., Frese, L., Fishbane, S., Maesaka, J.K. Neuroreport (2001) [Pubmed]
  10. Secretion of lipocalin-type prostaglandin D synthase (beta-trace) from human heart to plasma during coronary circulation. Urade, Y., Eguchi, Y., Eguchi, N., Kijima, Y., Matsuura, Y., Oda, H., Seiki, K., Hayaishi, O. Adv. Exp. Med. Biol. (1999) [Pubmed]
  11. Binding of biliverdin, bilirubin, and thyroid hormones to lipocalin-type prostaglandin D synthase. Beuckmann, C.T., Aoyagi, M., Okazaki, I., Hiroike, T., Toh, H., Hayaishi, O., Urade, Y. Biochemistry (1999) [Pubmed]
  12. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Gerashchenko, D.Y., Beuckmann, C.T., Marcheselli, V.L., Gordon, W.C., Kanaoka, Y., Eguchi, N., Urade, Y., Hayaishi, O., Bazan, N.G. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  13. Cellular localization of lipocalin-type prostaglandin D synthase (beta-trace) in the central nervous system of the adult rat. Beuckmann, C.T., Lazarus, M., Gerashchenko, D., Mizoguchi, A., Nomura, S., Mohri, I., Uesugi, A., Kaneko, T., Mizuno, N., Hayaishi, O., Urade, Y. J. Comp. Neurol. (2000) [Pubmed]
  14. Prostaglandin D2 and E2 syntheses in rat Kupffer cells are antagonistically regulated by lipopolysaccharide and phorbol ester. Grewe, M., Duyster, J., Dieter, P., Henninger, H., Schulze-Specking, A., Decker, K. Biol. Chem. Hoppe-Seyler (1992) [Pubmed]
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