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Gene Review

Cops5  -  COP9 (constitutive photomorphogenic)...

Mus musculus

Synonyms: AI303502, COP9 complex S5, COP9 signalosome complex subunit 5, CSN5, Csn5, ...
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Disease relevance of Cops5


High impact information on Cops5


Biological context of Cops5

  • In addition, a high level of Jab1 is observed in a variety of human cancers and is sometimes correlated with a poor prognosis, suggesting that Jab1 contributes to cancer cell proliferation and survival and could be a novel target of cancer therapy [6].
  • We obtained Jun-activation-domain-binding protein 1 (Jab1) as a new Brn-2 binding protein [1].
  • These results indicate that cytoplasmic shuttling regulated by Jab1/CSN5 and other CSN components may be a new pathway to control the intracellular abundance of the key cell cycle regulator [7].
  • Alteration of conserved leucine residues to alanine within Jab1/CSN5-NES abolished the interaction with CRM1 in vitro and impaired LMB-sensitive nuclear export and the ability to induce p27 breakdown in cultured cells [7].
  • Here we describe experiments that showing phosphorylation of p27(Kip1) at serine 10 leads to the suppression of Jab1 levels with the concomitant inhibition of c-Jun-dependent transcription [8].

Anatomical context of Cops5

  • In the adult brain, additional areas of JAB1/CSN5 expression were the hippocampus and the Purkinjie layer of the cerebellum [9].
  • Preferential expression in selected tissues was detected starting at E11.5, with higher levels in dorsal root ganglia; at later stages, prominent expression of JAB1/CSN5 transcripts was observed in cranial nerve, spinal and sympathetic ganglia, as well as in selected epithelia, such as the oral and the olfactory epithelium [9].
  • When Jab1 expression and lymph node status are combined, patients with Jab1(+)/lymph node(+) revealed poorer disease-free andoverall survival than others (P < 0.0001 and P < 0.0001, respectively) [10].

Associations of Cops5 with chemical compounds

  • Glycerol gradient and cell fractionation experiments showed that at least two different forms of Jab1/CSN5-containing complexes existed within the cell [7].
  • Nuclear-cytoplasmic translocation plays an important role because leptomycin B (LMB), a chemical inhibitor of CRM1-dependent nuclear export, prevents p27 degradation mediated by Jab1/CSN5 [7].

Physical interactions of Cops5

  • Additional far Western and pull-down studies with Id3 support our two-hybrid data and show that the transcription regulator can bind to CSN5 and CSN7 [11].

Other interactions of Cops5


  1. The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved in the onset of neurodegenerative diseases. Huang, Y.T., Iwamoto, K., Kurosaki, T., Nasu, M., Ueda, S. Neurosci. Lett. (2005) [Pubmed]
  2. Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors. Korbonits, M., Chahal, H.S., Kaltsas, G., Jordan, S., Urmanova, Y., Khalimova, Z., Harris, P.E., Farrell, W.E., Claret, F.X., Grossman, A.B. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  3. Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines. Fukumoto, A., Tomoda, K., Yoneda-Kato, N., Nakajima, Y., Kato, J.Y. FEBS Lett. (2006) [Pubmed]
  4. Psoriasin interacts with Jab1 and influences breast cancer progression. Emberley, E.D., Niu, Y., Leygue, E., Tomes, L., Gietz, R.D., Murphy, L.C., Watson, P.H. Cancer Res. (2003) [Pubmed]
  5. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. Tomoda, K., Yoneda-Kato, N., Fukumoto, A., Yamanaka, S., Kato, J.Y. J. Biol. Chem. (2004) [Pubmed]
  6. Preparation and Characterization of Monoclonal Antibodies Against Mouse Jab1/CSN5 Protein. Kato, J.Y., Nakamae, I., Tomoda, K., Fukumoto, A., Yoneda-Kato, N. Hybridoma (2005) (2006) [Pubmed]
  7. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. Tomoda, K., Kubota, Y., Arata, Y., Mori, S., Maeda, M., Tanaka, T., Yoshida, M., Yoneda-Kato, N., Kato, J.Y. J. Biol. Chem. (2002) [Pubmed]
  8. Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1. Chopra, S., Fernandez De Mattos, S., Lam, E.W., Mann, D.J. J. Biol. Chem. (2002) [Pubmed]
  9. Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8. Carrabino, S., Carminati, E., Talarico, D., Pardi, R., Bianchi, E. Gene Expr. Patterns (2004) [Pubmed]
  10. Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas. Dong, Y., Sui, L., Watanabe, Y., Yamaguchi, F., Hatano, N., Tokuda, M. Clin. Cancer Res. (2005) [Pubmed]
  11. Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome. Berse, M., Bounpheng, M., Huang, X., Christy, B., Pollmann, C., Dubiel, W. J. Mol. Biol. (2004) [Pubmed]
  12. Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation. Fukumoto, A., Tomoda, K., Kubota, M., Kato, J.Y., Yoneda-Kato, N. FEBS Lett. (2005) [Pubmed]
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