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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cholinergic Fibers

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Disease relevance of Cholinergic Fibers

  • That is to say, it is easier for the investigator to detect the cholinergic fiber and ganglion cell in the gut wall using NADPH-diaphorase staining than by using AChE staining [1].

Psychiatry related information on Cholinergic Fibers


High impact information on Cholinergic Fibers

  • Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity [3].
  • Muscarinic activation, either by repetitive stimulation of cholinergic fibers or by bath-applied carbachol, strongly increased intradendritic Ca2+ accumulation during directly evoked repetitive firing, in part by blocking a Ca(2+)-dependent K+ conductance [4].
  • The effects of repetitive stimulation of cholinergic fibers were enhanced by the acetylcholine-esterase blocker eserine and blocked by the muscarinic antagonist atropine [4].
  • We also show by choline acetyl transferase immunohistochemistry that the MHb is cholinergic and sends cholinergic fibers to the Uva [5].
  • This effect is persistent and can be mimicked by endogenous acetylcholine released from cholinergic fibers [6].

Biological context of Cholinergic Fibers

  • The results of this study indicate that FF transection leads to perikaryal shrinkage with loss of ChAT immunoreactivity, perikaryal phosphorylation of NFs, cholinergic fiber abnormalities, and cell loss [7].

Anatomical context of Cholinergic Fibers


Associations of Cholinergic Fibers with chemical compounds


Gene context of Cholinergic Fibers


Analytical, diagnostic and therapeutic context of Cholinergic Fibers


  1. Histological studies on Hirschsprung's disease and its allied disorders in childhood. Tomita, R., Munakata, K., Howard, E.R., Fujisaki, S. Hepatogastroenterology (2004) [Pubmed]
  2. Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease. Geula, C., Mesulam, M.M. Cereb. Cortex (1996) [Pubmed]
  3. Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum. Zhou, F.M., Liang, Y., Dani, J.A. Nat. Neurosci. (2001) [Pubmed]
  4. Cholinergic input uncouples Ca2+ changes from K+ conductance activation and amplifies intradendritic Ca2+ changes in hippocampal neurons. Müller, W., Connor, J.A. Neuron (1991) [Pubmed]
  5. Connections of thalamic modulatory centers to the vocal control system of the zebra finch. Akutagawa, E., Konishi, M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Nicotine activates immature "silent" connections in the developing hippocampus. Maggi, L., Le Magueresse, C., Changeux, J.P., Cherubini, E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Aberrant phosphorylation of neurofilaments accompanies transmitter-related changes in rat septal neurons following transection of the fimbria-fornix. Koliatsos, V.E., Applegate, M.D., Kitt, C.A., Walker, L.C., DeLong, M.R., Price, D.L. Brain Res. (1989) [Pubmed]
  8. Maturation and maintenance of cholinergic medial septum neurons require glucocorticoid receptor signaling. Guijarro, C., Rutz, S., Rothmaier, K., Turiault, M., Zhi, Q., Naumann, T., Frotscher, M., Tronche, F., Jackisch, R., Kretz, O. J. Neurochem. (2006) [Pubmed]
  9. Sprouting of central noradrenergic fibers in the dentate gyrus following combined lesions of its entorhinal and septal afferents. Peterson, G.M. Hippocampus. (1994) [Pubmed]
  10. Localization of the m2 muscarinic acetylcholine receptor protein and mRNA in cortical neurons of the normal and cholinergically deafferented rhesus monkey. Mrzljak, L., Levey, A.I., Belcher, S., Goldman-Rakic, P.S. J. Comp. Neurol. (1998) [Pubmed]
  11. Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease. Emre, M., Heckers, S., Mash, D.C., Geula, C., Mesulam, M.M. J. Comp. Neurol. (1993) [Pubmed]
  12. Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain. Beeson, J.G., Shelton, E.R., Chan, H.W., Gage, F.H. J. Comp. Neurol. (1994) [Pubmed]
  13. Effects of two years of estrogen loss or replacement on nucleus basalis cholinergic neurons and cholinergic fibers to the dorsolateral prefrontal and inferior parietal cortex of monkeys. Tinkler, G.P., Tobin, J.R., Voytko, M.L. J. Comp. Neurol. (2004) [Pubmed]
  14. Neurochemical architecture of the human striatum. Holt, D.J., Graybiel, A.M., Saper, C.B. J. Comp. Neurol. (1997) [Pubmed]
  15. Intraocular grafts of fresh and freeze-stored rat hippocampal tissue: a comparison of survivability and histological and connective organization. Jensen, S., Sørensen, T., Møller, A.G., Zimmer, J. J. Comp. Neurol. (1984) [Pubmed]
  16. Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex. Stancampiano, R., Carta, M., Cocco, S., Curreli, R., Rossetti, Z.L., Fadda, F. Brain Res. (2004) [Pubmed]
  17. Cholinergic fiber perturbations and neuritic outgrowth produced by intrafimbrial infusion of the neurofilament-disrupting agent 2,5-hexanedione. Di Patre, P.L., Butcher, L.L. Brain Res. (1991) [Pubmed]
  18. Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing beta-amyloid precursor protein (APP) with the Swedish double mutation (APP23). Diez, M., Danner, S., Frey, P., Sommer, B., Staufenbiel, M., Wiederhold, K.H., Hökfelt, T. Neurobiol. Dis. (2003) [Pubmed]
  19. Time course of neocortical graft innervation by AChE-positive fibers. Clinton, R.J., Ebner, F.F. J. Comp. Neurol. (1988) [Pubmed]
  20. Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. Shinoe, T., Matsui, M., Taketo, M.M., Manabe, T. J. Neurosci. (2005) [Pubmed]
  21. Splanchnic neural regulation of somatostatin secretion in the isolated perfused human pancreas. Brunicardi, F.C., Elahi, D., Andersen, D.K. Ann. Surg. (1994) [Pubmed]
  22. Origins and pathways of choline acetyltransferase-positive parasympathetic nerve fibers to cerebral vessels in rat. Suzuki, N., Hardebo, J.E., Owman, C. J. Cereb. Blood Flow Metab. (1990) [Pubmed]
  23. Importance of cholinergic innervation of the pancreas for glucose tolerance in the rat. Trimble, E.R., Berthoud, H.R., Siegel, E.G., Jeanrenaud, B., Renold, A.E. Am. J. Physiol. (1981) [Pubmed]
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