Disease relevance of KITLG

• We showed that SCF was efficient in increasing the toxicity of Ara-C on the self-renewing blast progenitors, especially with high concentrations of Ara-C [1].

High impact information on KITLG

• These mesenchymal-epithelial cell interactions are in part mediated by keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and Kit ligand (KL) [2].
• Over 90% of the bound [3H]SCF was competitively inhibited by excess unlabeled SCF and several other inhibin preparations of testicular origin: high mol wt fraction of ram testis fluid (mol wt, greater than 10,000), low mol wt fraction of ram testis fluid (mol wt, less than 5,000), ovine testicular lymph, and aqueous rat testicular extract [3].
• Culture of CD34(+) cells on FN significantly reduced the generation of mature myeloid cells vs those cultured on BSA-coated wells, and could be overcome by addition of SCF [4].
• Insulin powder containing citric acid prepared by the SCF method (MIC SCF) showed improved inhalation performance compared with insulin powder prepared by the SD process, although the particle size of the former powder was larger than that in powders prepared by SD [5].
• The dry powders, with mannitol as a carrier, were prepared with or without an absorption enhancer (citric acid) by supercritical carbon dioxide (SCF) and spray drying (SD) processes [5].

Biological context of KITLG

• Our data suggest that this mutation in the bovine MGF gene is responsible for the roan phenotype [6].
• A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle [6].
• PCR primers to the exons of this candidate gene, the steel locus or mast cell growth factor (MGF) were designed [6].
• Thecal cell-granulosa cell interactions involve a positive feedback loop among keratinocyte growth factor, hepatocyte growth factor, and Kit ligand during ovarian follicular development [2].
• However, a large patient-to-patient heterogeneity was found and the activity of SCF was not correlated with its effect on the cell cycle [1].

Anatomical context of KITLG

• RESULTS: Similar to FBS, human serum dose-dependently suppressed the growth of tryptase+ cells from CD34+ cord blood cells or 20-week cultured mast cells under stimulation with stem cell factor (SCF) [7].
• However, LIF treatment did increase expression of Kit ligand (KL) mRNA in cultured granulosa cells [8].
• Kit ligand actions on ovarian stromal cells: effects on theca cell recruitment and steroid production [9].
• OBJECTIVE: To characterize the expression and distribution of the Kit receptor in bovine bone marrow cells (BMC) and to define the function of its ligand, stem cell factor (SCF) [10].
• Semisolid cultures supplemented with granulocyte colony-stimulating factor (G-CSF) and SCF were used to measure the colony formation capacity of Kit+ BMC [10].

Associations of KITLG with chemical compounds

• These data indicate that SCF can enhance sensitivity to Ara-C of some leukemic cells with self-renewing capacity [1].

Analytical, diagnostic and therapeutic context of KITLG

• Our results also indicate that the pituitary binding may be used as a rapid radioreceptor assay for SCF and various other inhibin preparations [3].
• Two isoforms of SCF mRNA were amplified by RT-PCR [11].
• Stem cell factor (SCF) and ET-1 treated cells were also examined for migration into micropore filters coated with the same protein [12].

References