The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

KITLG  -  KIT ligand

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of KITLG

  • We showed that SCF was efficient in increasing the toxicity of Ara-C on the self-renewing blast progenitors, especially with high concentrations of Ara-C [1].

High impact information on KITLG

  • These mesenchymal-epithelial cell interactions are in part mediated by keratinocyte growth factor (KGF), hepatocyte growth factor (HGF), and Kit ligand (KL) [2].
  • Over 90% of the bound [3H]SCF was competitively inhibited by excess unlabeled SCF and several other inhibin preparations of testicular origin: high mol wt fraction of ram testis fluid (mol wt, greater than 10,000), low mol wt fraction of ram testis fluid (mol wt, less than 5,000), ovine testicular lymph, and aqueous rat testicular extract [3].
  • Culture of CD34(+) cells on FN significantly reduced the generation of mature myeloid cells vs those cultured on BSA-coated wells, and could be overcome by addition of SCF [4].
  • Insulin powder containing citric acid prepared by the SCF method (MIC SCF) showed improved inhalation performance compared with insulin powder prepared by the SD process, although the particle size of the former powder was larger than that in powders prepared by SD [5].
  • The dry powders, with mannitol as a carrier, were prepared with or without an absorption enhancer (citric acid) by supercritical carbon dioxide (SCF) and spray drying (SD) processes [5].

Biological context of KITLG


Anatomical context of KITLG

  • RESULTS: Similar to FBS, human serum dose-dependently suppressed the growth of tryptase+ cells from CD34+ cord blood cells or 20-week cultured mast cells under stimulation with stem cell factor (SCF) [7].
  • However, LIF treatment did increase expression of Kit ligand (KL) mRNA in cultured granulosa cells [8].
  • Kit ligand actions on ovarian stromal cells: effects on theca cell recruitment and steroid production [9].
  • OBJECTIVE: To characterize the expression and distribution of the Kit receptor in bovine bone marrow cells (BMC) and to define the function of its ligand, stem cell factor (SCF) [10].
  • Semisolid cultures supplemented with granulocyte colony-stimulating factor (G-CSF) and SCF were used to measure the colony formation capacity of Kit+ BMC [10].

Associations of KITLG with chemical compounds

  • These data indicate that SCF can enhance sensitivity to Ara-C of some leukemic cells with self-renewing capacity [1].

Analytical, diagnostic and therapeutic context of KITLG


  1. Effect of stem cell factor on leukemic progenitor cell growth and sensitivity to cytosine-arabinoside. Viallard, J.F., Grosset, C., Lacombe, F., David, S., Mahon, F.X., Barbot, C., Vianes, I., Dupouy, M., Reiffers, J. Leuk. Res. (1996) [Pubmed]
  2. Thecal cell-granulosa cell interactions involve a positive feedback loop among keratinocyte growth factor, hepatocyte growth factor, and Kit ligand during ovarian follicular development. Parrott, J.A., Skinner, M.K. Endocrinology (1998) [Pubmed]
  3. Pituitary binding of 3H-labeled Sertoli cell factor in vitro: a potential radioreceptor assay for inhibin. Seethalakshmi, L., Steinberger, A., Steinberger, E. Endocrinology (1984) [Pubmed]
  4. Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Dylla, S.J., Deyle, D.R., Theunissen, K., Padurean, A.M., Verfaillie, C.M. Exp. Hematol. (2004) [Pubmed]
  5. Improvement of insulin absorption from intratracheally administrated dry powder prepared by supercritical carbon dioxide process. Todo, H., Iida, K., Okamoto, H., Danjo, K. Journal of pharmaceutical sciences. (2003) [Pubmed]
  6. A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle. Seitz, J.J., Schmutz, S.M., Thue, T.D., Buchanan, F.C. Mamm. Genome (1999) [Pubmed]
  7. Serum inhibitors for human mast cell growth: possible role of retinol. Ishida, S., Kinoshita, T., Sugawara, N., Yamashita, T., Koike, K. Allergy (2003) [Pubmed]
  8. Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries. Nilsson, E.E., Kezele, P., Skinner, M.K. Mol. Cell. Endocrinol. (2002) [Pubmed]
  9. Kit ligand actions on ovarian stromal cells: effects on theca cell recruitment and steroid production. Parrott, J.A., Skinner, M.K. Mol. Reprod. Dev. (2000) [Pubmed]
  10. Expression and distribution of the Kit receptor in bovine bone marrow cells. Hikono, H., Ohta, M., Zhou, J.H., Sakurai, M. Am. J. Vet. Res. (2001) [Pubmed]
  11. Bovine stem cell factor: production of a biologically active protein and mRNA analysis in cattle infected with Trypanosoma congolense. Mertens, B., Muriuki, C., Muiya, P., Andrianarivo, A., Mwangi, S., Logan-Henfrey, L. Vet. Immunol. Immunopathol. (1997) [Pubmed]
  12. Effects of endothelin-1 on melanocyte adhesion and migration. Mou, K.H., Zhang, X.Q., Yu, B., Zhang, Z.L., Feng, J. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. (2004) [Pubmed]
WikiGenes - Universities