Disease relevance of KITLG

• Alterations in plasma and CSF amino acids, amines and metabolites in hepatic coma [1].
• The control group, which received intraventricular artificial CSF, developed minimal ventricular fluid acidosis (pH 7.26) [2].
• When halothane or enflurane were used for anesthesia, the CSF pressure-lowering effect of hypocapnia was not sustained [3].
• Experimental intraventricular hemorrhage was produced by injection of autologous fresh blood (0.25 ml/kg) or artificial CSF into the right lateral ventricle of 24 dogs [2].
• Levels of brain creatine kinase (CK), aspartate aminotransferase (ASAT), and lactate dehydrogenase (LD) in CSF after cardiac arrest were studied in dog models [4].

Psychiatry related information on KITLG

• However, these findings do not negate the possibility that Ang II acts synergistically with CSF Na+, but not plasma Na+, to modulate drinking behavior [5].

High impact information on KITLG

• Less pronounced but significant elevations in monocytes occurred during G-CSF treatment [6].
• However, there was an increase in the concentration of eicosanoids in CSF, and the elevation of 6-keto-PGF1 alpha paralleled the vasodilation [7].
• In another experiment, an intrinsic PKC activator, 1,2-diacylglycerol (DAG), in the basilar artery, the CSF, and the cisternal clot of beagles exposed to two hemorrhages was measured on days 1, 2, 4, 7, and 14 using the DAG kinase method [8].
• This relationship of CBF to CMRO2 was examined in six anesthetized dogs that were subjected to 12 min of complete ischemia induced either by CSF compression or aortic occlusion [9].
• Hemoglobin and its metabolite, bilirubin, have been shown to be present in high concentrations in CSF following subarachnoid hemorrhage (SAH) [10].

Chemical compound and disease context of KITLG

• When isoflurane, fentanyl, or thiopental were used for anesthesia, the CSF pressure-lowering effect of hypocapnia was sustained [3].
• Low CSF GABA levels have been reported in epilepsy and also febrile convulsions of children [11].
• Plasma and CSF levels of insulin and glucose were also measured and compared during eating and insulin-induced hypoglycemia [12].
• Ionic composition of cisternal CSF in acute respiratory acidosis: lack of effect of large dose bumetanide [13].
• In this study, we report the effects of large dose intravenous bumetanide, a potent inhibitor of Na,K,2Cl carrier, on cisternal CSF ionic composition in acute respiratory acidosis in pentobarbital-anesthetized mechanically ventilated dogs [13].

Biological context of KITLG

• KITLG maps to canine chromosome 15 and is excluded as a candidate gene for merle in dogs [14].
• Normal flow values could be reestablished even at a raised CSFP if the perfusion pressure was increased by raising the arterial blood pressure [15].
• Part I of these studies (Artru, 1987) examined how cerebral blood volume (CBV), CSF volume, and brain tissue water and electrolytes determined CSF pressure during 4 h of hypocapnia in sedated dogs [3].
• PURPOSE: To determine the effect of intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) on optic disc movement and lamina cribrosa displacement using confocal scanning laser tomography (CSLT) [16].
• We conclude that 1) PP and insulin in CSF do not appear to play a major role in the short term regulation of food intake and acute changes in energy metabolism; and 2) PP, probably after entering the brain, may modulate brain function in such physiological situations as strenuous exercise [12].

Anatomical context of KITLG

• The effect of cerebrospinal fluid pressure (CSFP) on spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, was studied in dogs [15].
• CSFP was altered by the infusion of mock CSF into the lumbar subarachnoid space [15].
• Two plasmas were studied: One (AP1) contained electrolytes, amino acids, and albumin; the other (AP2) was similar to CSF and contained a mixture of 37 organic nutrients plus electrolytes and albumin [17].
• We infused the ganglion blocker, trimethaphan, intravenously into anesthetized dogs and measured the effects on mean arterial blood pressure (MAP) and on cisterna magna CSF levels of NE [18].
• In the dogs with healthy meninges the ratio CSF/plasma AUCs was 47% after 25 mg/kg and 33% after 12.5 mg/kg [19].

Associations of KITLG with chemical compounds

• With halothane the intracranial volume increase was comprised chiefly of cerebral blood and with enflurane the intracranial volume increase was comprised chiefly of CSF [3].
• At this time, brain water content was significantly less than normal, but both CSF osmolality and glycerol concentration were higher than plasma [20].
• In both groups, CSF [HCO3-] and [H+] increased approximately 3 mEq/L and 20 nEq/L, respectively [13].
• In this study the pentetrazole seizure threshold of dogs was compared with the concentration of GABA in the CSF and blood plasma [11].
• It was expected that the serotonin synthesis rates determined for the whole brain would be correlated with CSF 5-hydroxyindole-3-acetic acid concentrations, a measure of central serotonin turnover, because both measures were obtained at steady state [21].

Analytical, diagnostic and therapeutic context of KITLG

• Brain enzyme levels in CSF after cardiac arrest and resuscitation in dogs: markers of damage and predictors of outcome [4].
• The rebound rise in CSF pressure observed during the continuous administration of glycerol cannot be explained by rehydration of brain tissue but may be related to alterations in CSF dynamics [20].
• CSF [des Ang I]-Aogen exhibited a greater anion-exchange HPLC retention [22].
• Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations [21].
• Phlebotomy (24 +/- 3 ml.kg-1) significantly decreased MAPp (to 106 +/- 6 mmHg), CVP (to 1.6 +/- 0.6 mmHg), and CSFP (to 1.2 +/- 1.1 mmHg) [23].

References