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PAG1  -  pregnancy-associated glycoprotein 1

Bos taurus

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Disease relevance of PAG1B

  • Pregnancy-specific protein B and progesterone in monitoring viability of the embryo in early pregnancy in the cow after experimental infection with Actinomyces pyogenes [1].
  • Sequential monitoring of PSPB, which identifies embryonic death when a continuing fall in plasma concentration is demonstrated, is a better indicator of embryonic death following bacterial infection with A. pyogenes than plasma progesterone concentration, which falls only when infection is resolved [1].

High impact information on PAG1B


Biological context of PAG1B


Anatomical context of PAG1B


Associations of PAG1B with chemical compounds

  • Here, the sequential use of ammonium sulfate precipitation and Sepharose blue, anion-exchange, and cation-exchange chromatographies, as well as isoelectric elution from a Mono P column, has allowed several PAG1-related molecules to be purified from the medium after culture of explants from Day 100 sheep placentas [4].
  • In non-pregnant females without extended CL maintenance (progesterone less than 1.5 ng/ml on Day 24) and or showing a normal time of return to oestrus (Group 1, N = 63), PSPB concentrations were undetectable whatever the stage after AI except in 2 cows [14].
  • Cells were treated with PSPB (0, 2.5, 5.0 micrograms) and PGF2 alpha (0, 100, 200 ng) in a 3 x 3 factorial arrangement [11].
  • Luteal PGE2 production increased in response to PSPB treatment (P < 0.01) and PGF2 alpha treatment (P < 0.001) [11].
  • Analysis of the various peptide binding subsites demonstrates why both bovine and ovine PAG-1 are capable of binding pepstatin [15].

Other interactions of PAG1B


Analytical, diagnostic and therapeutic context of PAG1B


  1. Pregnancy-specific protein B and progesterone in monitoring viability of the embryo in early pregnancy in the cow after experimental infection with Actinomyces pyogenes. Semambo, D.K., Eckersall, P.D., Sasser, R.G., Ayliffe, T.R. Theriogenology (1992) [Pubmed]
  2. Pregnancy-specific protein B induces release of an alpha chemokine in bovine endometrium. Austin, K.J., King, C.P., Vierk, J.E., Sasser, R.G., Hansen, T.R. Endocrinology (1999) [Pubmed]
  3. Expression of trophoblast cell-specific pregnancy-related genes in somatic cell-cloned bovine pregnancies. Patel, O.V., Yamada, O., Kizaki, K., Takahashi, T., Imai, K., Takahashi, S., Izaike, Y., Schuler, L.A., Takezawa, T., Hashizume, K. Biol. Reprod. (2004) [Pubmed]
  4. Multiple pregnancy-associated glycoproteins are secreted by day 100 ovine placental tissue. Xie, S., Green, J., Bao, B., Beckers, J.F., Valdez, K.E., Hakami, L., Roberts, R.M. Biol. Reprod. (1997) [Pubmed]
  5. Trophoblast-specific processing and phosphorylation of pregnancy-associated glycoprotein-1 in day 15 to 25 sheep placenta. Xie, S., Nagel, R.J., Green, J., Beckers, J.F., Roberts, R.M. Biol. Reprod. (1996) [Pubmed]
  6. A novel glycoprotein of the aspartic proteinase gene family expressed in bovine placental trophectoderm. Xie, S., Low, B.G., Nagel, R.J., Beckers, J.F., Roberts, R.M. Biol. Reprod. (1994) [Pubmed]
  7. Detection of pregnancy by radioimmunoassay of a novel pregnancy-specific protein in serum of cows and a profile of serum concentrations during gestation. Sasser, R.G., Ruder, C.A., Ivani, K.A., Butler, J.E., Hamilton, W.C. Biol. Reprod. (1986) [Pubmed]
  8. Pregnancy-specific protein B in serum of postpartum beef cows. Kiracofe, G.H., Wright, J.M., Schalles, R.R., Ruder, C.A., Parish, S., Sasser, R.G. J. Anim. Sci. (1993) [Pubmed]
  9. Light and electron microscopic immunolocalization of bovine pregnancy-associated glycoprotein in the bovine placentome. Zoli, A.P., Demez, P., Beckers, J.F., Reznik, M., Beckers, A. Biol. Reprod. (1992) [Pubmed]
  10. Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses. Hill, J.R., Burghardt, R.C., Jones, K., Long, C.R., Looney, C.R., Shin, T., Spencer, T.E., Thompson, J.A., Winger, Q.A., Westhusin, M.E. Biol. Reprod. (2000) [Pubmed]
  11. Bovine luteal cell production in vitro of prostaglandin E2, oxytocin and progesterone in response to pregnancy-specific protein B and prostaglandin F2 alpha. Del Vecchio, R.P., Sutherland, W.D., Sasser, R.G. J. Reprod. Fertil. (1996) [Pubmed]
  12. Pregnancy associated glycoprotein-1, -6, -7, and -17 are major products of bovine binucleate trophoblast giant cells at midpregnancy. Klisch, K., De Sousa, N.M., Beckers, J.F., Leiser, R., Pich, A. Mol. Reprod. Dev. (2005) [Pubmed]
  13. Plasma pregnancy-associated glycoprotein-1 (PAG-1) concentrations during gestation in Neospora-infected dairy cows. L??pez-Gatius, F., Garbayo, J.M., Santolaria, P., Y??niz, J.L., Almer??a, S., Ayad, A., de Sousa, N.M., Beckers, J.F. Theriogenology (2007) [Pubmed]
  14. Pregnancy-specific protein B, progesterone concentrations and embryonic mortality during early pregnancy in dairy cows. Humblot, F., Camous, S., Martal, J., Charlery, J., Jeanguyot, N., Thibier, M., Sasser, R.G. J. Reprod. Fertil. (1988) [Pubmed]
  15. Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Guruprasad, K., Blundell, T.L., Xie, S., Green, J., Szafranska, B., Nagel, R.J., McDowell, K., Baker, C.B., Roberts, R.M. Protein Eng. (1996) [Pubmed]
  16. Bovine trophoblast cell culture systems: a technique to culture bovine trophoblast cells without feeder cells. Hashizume, K., Shimada, A., Nakano, H., Takahashi, T. Methods Mol. Med. (2006) [Pubmed]
  17. Radioimmunoassay of a bovine pregnancy-associated glycoprotein in serum: its application for pregnancy diagnosis. Zoli, A.P., Guilbault, L.A., Delahaut, P., Ortiz, W.B., Beckers, J.F. Biol. Reprod. (1992) [Pubmed]
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