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Ccl7  -  chemokine (C-C motif) ligand 7

Rattus norvegicus

Synonyms: C-C motif chemokine 7, MCP-3, Mcp3, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, ...
 
 
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Disease relevance of Ccl7

  • The temporal expression of MCP-3 mRNA was examined in brain tissue rendered ischemia by permanent or temporary occlusion of the middle cerebral artery (MCAO) [1].
  • Given the focal hypoxia observed with vaginal distention, we characterized stromal derived factor-1 and monocyte chemotactic protein-3 expression by pelvic organ tissues after vaginal distention [2].
  • Stromal derived factor-1 and monocyte chemotactic protein-3 were identified as cytokines that are over expressed after myocardial ischemia and signal stem cell migration to ischemic sites in a rat cardiac model [2].
  • We previously reported that the gene expression of six CC chemokines-MCP-1, MCP-3, MIP-1alpha, MIP-1beta, RANTES, and TCA3-was enhanced in a rat model of crescentic glomerulonephritis, the most severe form of glomerulonephritis [3].
  • We previously reported that among six chemokines, the expression of mRNAs for MCP-1, MCP-3, TCA3, and MIP-1alpha, but not for MIP-1beta and RANTES, was markedly elevated in the renal cortex of rats with puromycin aminonucleoside induced nephrosis [4].
 

High impact information on Ccl7

 

Biological context of Ccl7

 

Anatomical context of Ccl7

 

Associations of Ccl7 with chemical compounds

  • Thus, the results are consistent with a dual mechanism for ethanol-induced reductions in steady-state MCP-3 mRNA levels [5].
 

Other interactions of Ccl7

  • In the present study we investigated the expression of mRNAs for other CC chemokines, namely, MCP-3, macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, RANTES and TCA3, all of which are chemotactic for monocytes, in the CGN model [7].
  • The levels of mRNAs for MCP-1, MCP-3, and lymphotactin increased on day 5 and returned to their normal levels by day 7 [4].
 

Analytical, diagnostic and therapeutic context of Ccl7

References

  1. Molecular cloning and expression of the rat monocyte chemotactic protein-3 gene: a possible role in stroke. Wang, X., Li, X., Yaish-Ohad, S., Sarau, H.M., Barone, F.C., Feuerstein, G.Z. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  2. Over expression of stem cell homing cytokines in urogenital organs following vaginal distention. Woo, L.L., Hijaz, A., Kuang, M., Penn, M.S., Damaser, M.S., Rackley, R.R. J. Urol. (2007) [Pubmed]
  3. Gene expression of CC chemokines in experimental acute tubulointerstitial nephritis. Ou, Z.L., Natori, Y., Natori, Y. J. Lab. Clin. Med. (1999) [Pubmed]
  4. Transient and sequential expression of chemokine mRNA in glomeruli in puromycin aminonucleoside nephrosis. Ou, Z.L., Natori, Y., Natori, Y. Nephron (2000) [Pubmed]
  5. Dual mechanisms for ethanol-induced inhibition of monocyte chemotactic protein-3 mRNA expression in activated glial cells. Ren, L., Syapin, P.J. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  6. Expression of monocyte chemotactic protein-3 mRNA in rat vascular smooth muscle cells and in carotid artery after balloon angioplasty. Wang, X., Li, X., Yue, T.L., Ohlstein, E.H. Biochim. Biophys. Acta (2000) [Pubmed]
  7. Gene expression of CC chemokines in experimental crescentic glomerulonephritis (CGN). Natori, Y., Sekiguchi, M., Ou, Z., Natori, Y. Clin. Exp. Immunol. (1997) [Pubmed]
 
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