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Gene Review

Ccl7  -  chemokine (C-C motif) ligand 7

Mus musculus

Synonyms: C-C motif chemokine 7, Fic, Intercrine/chemokine MARC, MCP-3, Mcp3, ...
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Disease relevance of Ccl7

  • CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation [1].
  • Vectors were constructed based on the autonomous parvovirus minute virus of mice (MVMp), carrying the human (MCP-3) cDNA [2].
  • The antitumor effects of the MCP-3-transducing vector were not restricted to this tumor model since they could also be observed in the K1735 melanoma [2].
  • To determine the biological activity of FIC and to compare it with that of mouse MCP-1 (muMCP-1), both proteins were expressed in the baculovirus system [3].
  • Monocyte chemotactic protein-3 (MCP-3)/fibroblast-induced cytokine (FIC), a CC chemokine, is chemotactic for cells that typically infiltrate the late-phase allergic reaction [4].

High impact information on Ccl7


Chemical compound and disease context of Ccl7


Biological context of Ccl7


Anatomical context of Ccl7

  • Surprisingly, Abs to CCL7 and CXCL10 also decreased neutrophil recruitment by 63 and 72%, respectively [1].
  • The airway epithelium was identified as a source of CCL7 [1].
  • The latter data, together with tumor growth in nude mice and reverse-transcriptase (RT)-PCR analyses of MVMp/MCP3-treated tumors, clearly showed that activated CD4, CD8 and NK cells were indispensable for the antineoplastic effect in the B78/H1 tumor [2].
  • These latter effects would appear to be selective because no changes were observed when macrophage-inflammatory protein-1alpha, eotaxin, or MCP-3 were instilled into the airways of normal mice or when mast cells were treated in vitro [13].
  • It is tempting to speculate that altered trafficking of APCs, which express receptors and respond to MCP-3, together with recruitment of activated T cells, underlies activation of specific immunity by MCP-3-transfected cells [14].

Associations of Ccl7 with chemical compounds

  • The murine Fic cDNA, which encodes a Marc-mutant protein with an arginine substitution for alanine, was not identified in the other sequenced homologous isolates [15].
  • We conclude that MCP-3/FIC plays a significant role in the allergen-induced eosinophilic inflammation of the airways [4].
  • The IL-12 suppression occurred at the level of mRNA accumulation for IL-12 genes in response to LPS stimulation, but the infection induced a marked accumulation of mRNA for both MCP-1 and MCP-3, which are known to suppress IL-12 production in LPS-stimulated macrophages [16].
  • Estrogen specifically and preferentially promoted spleen chemokine protein expression for MCP-1 and MCP-3, while having no effect on dermal protein expression for these chemokines [17].
  • The cross-talk between Ru486 and amplified MCP3 expression may be one of the mechanisms by way of which RU486 performs its abortificient and anti tumor role [10].

Other interactions of Ccl7

  • These findings indicate that CCL7 and CXCL10, two chemokines not previously reported to orchestrate neutrophilic inflammation, play a critical role in mediating oxidative stress-induced neutrophilic airway inflammation [1].
  • In a non-target organ of acute GVHD, the heart, the predominant chemokines expressed were MCP-1 and MCP-3 [18].
  • Increased accumulation of macrophages and polymorphonuclear neutrophils was evident also in nude mice. mAb against CD4, CD8, and IFN-gamma, but not against IL-4, inhibited rejection of MCP-3-producing cells [14].
  • Analyses of mRNA levels by RNase protection assay (RPA) revealed increases in MCP-1 as well as MCP-3 and MIP-2 mRNA at 1 day postinjury compared with 7 day postinjury [19].
  • Recent evidence suggests an important role for MCP- 1, MCP-2 and MCP-3 in a number of pathological states, including delayed type hypersensitivity conditions, parasitic infections and rheumatoid arthritis [20].

Analytical, diagnostic and therapeutic context of Ccl7


  1. CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation. Michalec, L., Choudhury, B.K., Postlethwait, E., Wild, J.S., Alam, R., Lett-Brown, M., Sur, S. J. Immunol. (2002) [Pubmed]
  2. MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells. Wetzel, K., Struyf, S., Van Damme, J., Kayser, T., Vecchi, A., Sozzani, S., Rommelaere, J., Cornelis, J.J., Dinsart, C. Int. J. Cancer (2007) [Pubmed]
  3. The product of a novel growth factor-activated gene, fic, is a biologically active "C-C"-type cytokine. Heinrich, J.N., Ryseck, R.P., Macdonald-Bravo, H., Bravo, R. Mol. Cell. Biol. (1993) [Pubmed]
  4. Monocyte chemotactic protein-3 (MCP-3)/fibroblast-induced cytokine (FIC) in eosinophilic inflammation of the airways and the inhibitory effects of an anti-MCP-3/FIC antibody. Stafford, S., Li, H., Forsythe, P.A., Ryan, M., Bravo, R., Alam, R. J. Immunol. (1997) [Pubmed]
  5. BCL-6 regulates chemokine gene transcription in macrophages. Toney, L.M., Cattoretti, G., Graf, J.A., Merghoub, T., Pandolfi, P.P., Dalla-Favera, R., Ye, B.H., Dent, A.L. Nat. Immunol. (2000) [Pubmed]
  6. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. Ponath, P.D., Qin, S., Post, T.W., Wang, J., Wu, L., Gerard, N.P., Newman, W., Gerard, C., Mackay, C.R. J. Exp. Med. (1996) [Pubmed]
  7. Production of the novel C-C chemokine MCP-4 by airway cells and comparison of its biological activity to other C-C chemokines. Stellato, C., Collins, P., Ponath, P.D., Soler, D., Newman, W., La Rosa, G., Li, H., White, J., Schwiebert, L.M., Bickel, C., Liu, M., Bochner, B.S., Williams, T., Schleimer, R.P. J. Clin. Invest. (1997) [Pubmed]
  8. Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. Taub, D.D., Proost, P., Murphy, W.J., Anver, M., Longo, D.L., van Damme, J., Oppenheim, J.J. J. Clin. Invest. (1995) [Pubmed]
  9. Transfection of colorectal cancer cells with chemokine MCP-3 (monocyte chemotactic protein-3) gene retards tumor growth and inhibits tumor metastasis. Hu, J.Y., Li, G.C., Wang, W.M., Zhu, J.G., Li, Y.F., Zhou, G.H., Sun, Q.B. World J. Gastroenterol. (2002) [Pubmed]
  10. Mifepristone (Ru486) antagonizes monocyte chemotactic protein-3 down-regulation at early mouse pregnancy revealing immunomodulatory events in Ru486 induced abortion. Nautiyal, J., Kumar, P.G., Laloraya, M. Am. J. Reprod. Immunol. (2004) [Pubmed]
  11. Monocyte chemotactic protein-2, monocyte chemotactic protein-3, and fibroblast-induced cytokine. Three new chemokines induce chemotaxis and activation of basophils. Alam, R., Forsythe, P., Stafford, S., Heinrich, J., Bravo, R., Proost, P., Van Damme, J. J. Immunol. (1994) [Pubmed]
  12. Monocyte chemoattractant protein 3 as a mediator of fibrosis: Overexpression in systemic sclerosis and the type 1 tight-skin mouse. Ong, V.H., Evans, L.A., Shiwen, X., Fisher, I.B., Rajkumar, V., Abraham, D.J., Black, C.M., Denton, C.P. Arthritis Rheum. (2003) [Pubmed]
  13. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. Campbell, E.M., Charo, I.F., Kunkel, S.L., Strieter, R.M., Boring, L., Gosling, J., Lukacs, N.W. J. Immunol. (1999) [Pubmed]
  14. Reduced tumorigenicity and augmented leukocyte infiltration after monocyte chemotactic protein-3 (MCP-3) gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor. Fioretti, F., Fradelizi, D., Stoppacciaro, A., Ramponi, S., Ruco, L., Minty, A., Sozzani, S., Garlanda, C., Vecchi, A., Mantovani, A. J. Immunol. (1998) [Pubmed]
  15. Mouse macrophage derived monocyte chemotactic protein-3: cDNA cloning and identification as MARC/FIC. Thirion, S., Nys, G., Fiten, P., Masure, S., Van Damme, J., Opdenakker, G. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  16. Legionella pneumophila suppresses interleukin-12 production by macrophages. Matsunaga, K., Klein, T.W., Newton, C., Friedman, H., Yamamoto, Y. Infect. Immun. (2001) [Pubmed]
  17. Tissue-specific effect of estradiol on endothelial cell-dependent lymphocyte recruitment. Murphy, H.S., Sun, Q., Murphy, B.A., Mo, R., Huo, J., Chen, J., Chensue, S.W., Adams, M., Richardson, B.C., Yung, R. Microvasc. Res. (2004) [Pubmed]
  18. T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease. New, J.Y., Li, B., Koh, W.P., Ng, H.K., Tan, S.Y., Yap, E.H., Chan, S.H., Hu, H.Z. Bone Marrow Transplant. (2002) [Pubmed]
  19. Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion. Ma, M., Wei, T., Boring, L., Charo, I.F., Ransohoff, R.M., Jakeman, L.B. J. Neurosci. Res. (2002) [Pubmed]
  20. Induction of monocyte chemotactic protein-1 (MCP-1) and TNF alpha by Trichinella spiralis in serum of mice in vivo. Reale, M., Frydas, S., Barbacane, R.C., Placido, F.C., Cataldo, I., Vacalis, D., Trakatellis, A., Anogianakis, G., Felaco, M., Di Gioacchino, M., Conti, P. Mol. Cell. Biochem. (1998) [Pubmed]
  21. Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. Chen, A., Mumick, S., Zhang, C., Lamb, J., Dai, H., Weingarth, D., Mudgett, J., Chen, H., MacNeil, D.J., Reitman, M.L., Qian, S. Obes. Res. (2005) [Pubmed]
  22. Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. Minty, A., Chalon, P., Guillemot, J.C., Kaghad, M., Liauzun, P., Magazin, M., Miloux, B., Minty, C., Ramond, P., Vita, N. Eur. Cytokine Netw. (1993) [Pubmed]
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