Disease relevance of IGKV3D-7

• In Hashimoto's goiter, Graves' disease, and sporadic nontoxic goiter (which we consider an autoimmune thyroid disease) the numbers of dendritic cells were higher compared to those in the normal gland, and these dendritic cells were clearly positive for RFD1 and L25 [1].
• The Q27P or Q27R substitution in either HSV-1 and HSV-2 gD, but not the L25P substitution, significantly reduced cell fusion and binding activity for both human and mouse HVEM [2].

High impact information on IGKV3D-7

• Lymphocyte surface antigen L25 is a member of the integrin receptor superfamily [3].
• The analysis of L25 subunits from lysates of antigen-stimulated T lymphocytes revealed a loss of the Mr 150,000 polypeptides in mAb anti-L25 immunoprecipitates [3].
• This relationship placed L25 as a member of the integrin receptor superfamily [3].
• In contrast, the gamma(s)() value of D25 is found to be about 6 times as small as that of the para-substituted phenylacetylene oligomer (L25) composed of 24 units of phenylacetylenes [4].
• These dendritic cells in normal thyroid tissue lacked the marker molecules identified by the monoclonal antibodies RFD1 and L25 [1].

Biological context of IGKV3D-7

• Biopsy sections were stained with monoclonal antibodies: OKT6 (CD1a-Langerhans cells), Ki-M6 (CD68-macrophages), L25 (dendritic cells), anti-IgE, HLA-DR and HLA-DQ (Major Histocompatibility Complex Class II-antigen presenting cells), as well as staining with acid phosphatase [5].
• Southern blot analysis showed 2 copies of gene L25 per genome arranged in tandem position and pointing in the same direction [6].
• A cDNA clone codifying ribosomal protein L25 was isolated from a Leishmania braziliensis cDNA gene library [6].
• RESULTS: Two homozygous missense mutations, L25P and M368V, were identified, each of which leads to the replacement of a highly conserved amino acid in the HGO protein [7].
• The chromosomes from two human uterine lipoleiomyomas, L25 and L26, from the same patient, were studied by a banding technique applied to preparations from short-term cultures [8].

Anatomical context of IGKV3D-7

• Solid phase double determinant binding assays demonstrated that L25 is similar and probably identical to lymphocyte surface antigen very late activation-4 [3].
• Irregularly shaped cells with a marker pattern comparable to that of blood-derived DC (positive for DR, DQ, L25, RFD1, and CD68) were predominantly observed in the epithelium and subepithelial tissue of the bronch(iol)us and in the bronchus-associated lymphoid tissue [9].
• A novel cell-surface antigen (L25) expressed on human B cells was identified using a B cell-reactive monoclonal antibody (TB1-4D5) [10].
• Mouse liver microsomes activated aflatoxin B1 to a greater extent [(1 micro M) 12.8 +/- 2.51 SCE/Cell] than either rat [(10 micro M) 12.0 +/- 3.84 SCE/Cell or human (L25) [(10 micro M) 8.8 +/- 2.00 SCE/Cell liver microsomes [11].
• This L25 antigen was expressed on most B-lineage cells but not other cell types including thymocytes, T cells, granulocytes and monocytes [10].

Associations of IGKV3D-7 with chemical compounds

• In Exp. 1, the best multienzyme cocktail (ferulic acid esterase, xylanase, cellulase, endo-glucanase [I, II], and beta-glucanase) was developed using an orthogonal experimental design, L25 (5(6)), where L = orthogonal table; 6 = factors; 5 = five levels of each; and 25 = experimental number, for further in situ and/or in vivo study [12].

References