Gene Review:
AREG - amphiregulin
Homo sapiens
Synonyms:
AR, AREGB, Amphiregulin, CRDGF, Colorectum cell-derived growth factor, ...
- Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells. Mahtouk, K., Hose, D., Rème, T., De Vos, J., Jourdan, M., Moreaux, J., Fiol, G., Raab, M., Jourdan, E., Grau, V., Moos, M., Goldschmidt, H., Baudard, M., Rossi, J.F., Cremer, F.W., Klein, B. Oncogene (2005)
- Canonical WNT signaling pathway and human AREG. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2006)
- TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Gschwind, A., Hart, S., Fischer, O.M., Ullrich, A. EMBO J. (2003)
- Colorectum cell-derived growth factor (CRDGF) is homologous to amphiregulin, a member of the epidermal growth factor family. Culouscou, J.M., Remacle-Bonnet, M., Carlton, G.W., Plowman, G.D., Shoyab, M. Growth Factors (1992)
- Heparin-binding epidermal growth factor-like growth factor stimulates mitogenic signaling and is highly expressed in human malignant gliomas. Mishima, K., Higashiyama, S., Asai, A., Yamaoka, K., Nagashima, Y., Taniguchi, N., Kitanaka, C., Kirino, T., Kuchino, Y. Acta Neuropathol. (1998)
- Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells. Eckstein, N., Servan, K., Girard, L., Cai, D., von Jonquieres, G., Jaehde, U., Kassack, M.U., Gazdar, A.F., Minna, J.D., Royer, H.D. J. Biol. Chem. (2008)
- Upregulation of A2A adenosine receptors in platelets from patients affected by bipolar disorders under treatment with typical antipsychotics. Martini, C., Tuscano, D., Trincavelli, M.L., Cerrai, E., Bianchi, M., Ciapparelli, A., Alessio, L., Novelli, L., Catena, M., Lucacchini, A., Cassano, G.B., Dell'Osso, L. Journal of psychiatric research. (2006)
- Structure, expression and function of a schwannoma-derived growth factor. Kimura, H., Fischer, W.H., Schubert, D. Nature (1990)
- Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. Romano, M., Ricci, V., Di Popolo, A., Sommi, P., Del Vecchio Blanco, C., Bruni, C.B., Ventura, U., Cover, T.L., Blaser, M.J., Coffey, R.J., Zarrilli, R. J. Clin. Invest. (1998)
- Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. Cook, P.W., Piepkorn, M., Clegg, C.H., Plowman, G.D., DeMay, J.M., Brown, J.R., Pittelkow, M.R. J. Clin. Invest. (1997)
- Prostaglandin E2 synergistically enhances receptor tyrosine kinase-dependent signaling system in colon cancer cells. Shao, J., Evers, B.M., Sheng, H. J. Biol. Chem. (2004)
- Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells. Martinez-Lacaci, I., Johnson, G.R., Salomon, D.S., Dickson, R.B. J. Cell. Physiol. (1996)
- Increased expression of schwannoma-derived growth factor (SDGF) mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat gliomas. Mishima, K., Asai, A., Sugiyama, A., Miyagi, Y., Kitanaka, C., Kagaya, S., Kirino, T., Kuchino, Y. Int. J. Cancer (1996)
- Vitamin D-mediated growth inhibition of an androgen-ablated LNCaP cell line model of human prostate cancer. Yang, E.S., Maiorino, C.A., Roos, B.A., Knight, S.R., Burnstein, K.L. Mol. Cell. Endocrinol. (2002)
- The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity. Zitzmann, M., Brune, M., Kornmann, B., Gromoll, J., von Eckardstein, S., von Eckardstein, A., Nieschlag, E. J. Clin. Endocrinol. Metab. (2001)
- Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. Chokki, M., Eguchi, H., Hamamura, I., Mitsuhashi, H., Kamimura, T. FEBS J. (2005)
- Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7. Shoyab, M., McDonald, V.L., Bradley, J.G., Todaro, G.J. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Merchant, N.B., Rogers, C.M., Trivedi, B., Morrow, J., Coffey, R.J. Surgery (2005)
- The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion. Thorne, B.A., Plowman, G.D. Mol. Cell. Biol. (1994)
- Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. Kansra, S., Stoll, S.W., Johnson, J.L., Elder, J.T. Mol. Biol. Cell (2004)
- A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling. Wong, L., Deb, T.B., Thompson, S.A., Wells, A., Johnson, G.R. J. Biol. Chem. (1999)
- Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. Rittié, L., Varani, J., Kang, S., Voorhees, J.J., Fisher, G.J. J. Invest. Dermatol. (2006)
- Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Ciardiello, F., Kim, N., Saeki, T., Dono, R., Persico, M.G., Plowman, G.D., Garrigues, J., Radke, S., Todaro, G.J., Salomon, D.S. Proc. Natl. Acad. Sci. U.S.A. (1991)
- The role of amphiregulin in breast cancer. Salomon, D.S., Normanno, N., Ciardiello, F., Brandt, R., Shoyab, M., Todaro, G.J. Breast Cancer Res. Treat. (1995)
- Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines. Hurbin, A., Dubrez, L., Coll, J.L., Favrot, M.C. Ann. N. Y. Acad. Sci. (2003)
- Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke. Richter, A., O'Donnell, R.A., Powell, R.M., Sanders, M.W., Holgate, S.T., Djukanović, R., Davies, D.E. Am. J. Respir. Cell Mol. Biol. (2002)
- Co-expression of heparin-binding EGF-like growth factor and related peptides in human gastric carcinoma. Naef, M., Yokoyama, M., Friess, H., Büchler, M.W., Korc, M. Int. J. Cancer (1996)
- Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. Amsellem-Ouazana, D., Bièche, I., Tozlu, S., Botto, H., Debré, B., Lidereau, R. J. Urol. (2006)
- Cooperation of amphiregulin and insulin-like growth factor-1 inhibits Bax- and Bad-mediated apoptosis via a protein kinase C-dependent pathway in non-small cell lung cancer cells. Hurbin, A., Coll, J.L., Dubrez-Daloz, L., Mari, B., Auberger, P., Brambilla, C., Favrot, M.C. J. Biol. Chem. (2005)