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Gene Review

RPVgp1  -  N protein

Rinderpest virus (strain Kabete O)

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Disease relevance of RPVgp1


High impact information on RPVgp1

  • In the intracellular neutralization experiments, confocal immunofluorescence microscopy showed prominent colocalization of anti-H IgA and H protein inside virus-infected cells, whereas colocalization of anti-F and F protein and of anti-N and N protein was much less, in agreement with the neutralization results [6].
  • This IgA was also the most effective at intraepithelial cell neutralization after infection at the apical surface and endocytosis of IgA at the basolateral surface, although an antibody against the internal N protein was also effective [6].
  • Three defense functions of immunoglobulin A (IgA), immune exclusion, intracellular neutralization, and virus excretion, were assessed in a measles virus model using polarized epithelial cells expressing the polymeric immunoglobulin receptor and monoclonal antibodies against the viral H and F envelope proteins and the internal N protein [6].
  • In cell culture, expression of V protein led to a redistribution of MV N protein in doubly transfected Cos-7 cells, indicating that these proteins form heterologous complexes [7].
  • These findings indicate that V protein acts to balance accumulation of viral gene products in cell culture, and this may be dependent on its interaction with MV N protein [7].

Chemical compound and disease context of RPVgp1


Biological context of RPVgp1

  • This suggests that the association with the P protein may mask the binding site for the N46 MAb or that it induces a conformational change in the N protein [2].
  • These data suggest that the self-assembled form of measles N protein functions in Sendai DI genome synthesis [9].
  • The majority of the deduced amino acid sequence was further confirmed by direct sequencing of peptide fragments of the N protein derived from purified virions [10].
  • The lineage groups described from comparison of the nucleotide sequences encoding the C-terminal regions of the N protein of MV were the same as those derived from the H gene sequences in almost all cases [11].
  • There was no cross reaction between the two viruses in the test and the N protein could be detected in infected cell supernatants kept at ambient temperature for one week [12].

Anatomical context of RPVgp1

  • Depletion of CD8+ T lymphocytes did not abrogate the protective potential of the N protein-specific cell-mediated immune response in rats, while protection could be adoptively transferred with N protein-specific CD4+ T lymphocytes [1].
  • Immunized rats revealed polyvalent antibodies to the N protein of measles virus in the absence of any neutralizing antibodies as well as an N protein-specific proliferative lymphocyte response [1].
  • Paradoxically, this normally protective cellular response mediates redistribution of viral N protein from the cytoplasm into infected cell nuclei, which is the likely basis for complex nuclear body formation and a unique form of virus-induced cytopathic effect [13].
  • Following infection of human fibroblasts with RAd68 in vitro, recombinant N protein was synthesized as a 60-kDa protein that represented up to 20% total soluble cell protein [14].
  • Intranuclear inclusion bodies did not stain positively for the CDV nucleocapsid phosphoprotein nor was intranuclear N protein observed in the absence of nuclear or elevated cytoplasmic 72 kd HSP [13].

Associations of RPVgp1 with chemical compounds


Regulatory relationships of RPVgp1


Other interactions of RPVgp1

  • Furthermore, when the Sendai P-L polymerase complex was provided separately, measles N protein alone synthesized DI genome RNA in the absence of Sendai P protein [9].

Analytical, diagnostic and therapeutic context of RPVgp1

  • C3H/He mice immunized with rBCG::N developed T cell responses and ELISA antibodies to the N protein and low levels of neutralizing antibody after intracranial infection with MV strain CAM/R40 [18].
  • After immunofluorescence labelling and confocal microscopy, L.CD46 cells also displayed a significant increase in the co-localisation of the N protein with the cell surface H and F proteins [19].
  • Identification of immunodominant but PPRV-specific epitopes and domains will provide the foundation in designing an N-protein-based diagnostic immunoassay for PPRV [20].


  1. Measles virus nucleocapsid protein protects rats from encephalitis. Bankamp, B., Brinckmann, U.G., Reich, A., Niewiesk, S., ter Meulen, V., Liebert, U.G. J. Virol. (1991) [Pubmed]
  2. Conformational maturation of measles virus nucleocapsid protein. Gombart, A.F., Hirano, A., Wong, T.C. J. Virol. (1993) [Pubmed]
  3. Identification and phylogenetic comparison of Salem virus, a novel paramyxovirus of horses. Renshaw, R.W., Glaser, A.L., Van Campen, H., Weiland, F., Dubovi, E.J. Virology (2000) [Pubmed]
  4. Measles virus nucleocapsid protein expressed in insect cells assembles into nucleocapsid-like structures. Fooks, A.R., Stephenson, J.R., Warnes, A., Dowsett, A.B., Rima, B.K., Wilkinson, G.W. J. Gen. Virol. (1993) [Pubmed]
  5. Morbillivirus nucleoprotein possesses a novel nuclear localization signal and a CRM1-independent nuclear export signal. Sato, H., Masuda, M., Miura, R., Yoneda, M., Kai, C. Virology (2006) [Pubmed]
  6. Multiple functions of immunoglobulin A in mucosal defense against viruses: an in vitro measles virus model. Yan, H., Lamm, M.E., Björling, E., Huang, Y.T. J. Virol. (2002) [Pubmed]
  7. Expression of measles virus V protein is associated with pathogenicity and control of viral RNA synthesis. Tober, C., Seufert, M., Schneider, H., Billeter, M.A., Johnston, I.C., Niewiesk, S., ter Meulen, V., Schneider-Schaulies, S. J. Virol. (1998) [Pubmed]
  8. Comparison of proteins induced in cells infected with rinderpest and peste des petits ruminants viruses. Diallo, A., Barrett, T., Lefevre, P.C., Taylor, W.P. J. Gen. Virol. (1987) [Pubmed]
  9. Measles virus nucleocapsid protein can function in Sendai virus defective interfering particle genome synthesis in vitro. Chandrika, R., Myers, T., Moyer, S.A. Virology (1995) [Pubmed]
  10. Sequence analysis of the Hendra virus nucleoprotein gene: comparison with other members of the subfamily Paramyxovirinae. Yu, M., Hansson, E., Shiell, B., Michalski, W., Eaton, B.T., Wang, L.F. J. Gen. Virol. (1998) [Pubmed]
  11. Sequence divergence of measles virus haemagglutinin during natural evolution and adaptation to cell culture. Rima, B.K., Earle, J.A., Baczko, K., ter Meulen, V., Liebert, U.G., Carstens, C., Carabaña, J., Caballero, M., Celma, M.L., Fernandez-Muñoz, R. J. Gen. Virol. (1997) [Pubmed]
  12. Rapid differential diagnosis of rinderpest and peste des petits ruminants using an immunocapture ELISA. Libeau, G., Diallo, A., Colas, F., Guerre, L. Vet. Rec. (1994) [Pubmed]
  13. Cellular stress response induces selective intranuclear trafficking and accumulation of morbillivirus major core protein. Oglesbee, M., Krakowka, S. Lab. Invest. (1993) [Pubmed]
  14. High-level expression of the measles virus nucleocapsid protein by using a replication-deficient adenovirus vector: induction of an MHC-1-restricted CTL response and protection in a murine model. Fooks, A.R., Schadeck, E., Liebert, U.G., Dowsett, A.B., Rima, B.K., Steward, M., Stephenson, J.R., Wilkinson, G.W. Virology (1995) [Pubmed]
  15. Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells. Segev, Y., Ofir, R., Salzberg, S., Heller, A., Weinstein, Y., Isakov, N., Udem, S., Wolfson, M., Rager-Zisman, B. J. Virol. (1995) [Pubmed]
  16. Generation of mammalian cells expressing stably measles virus proteins via bicistronic RNA. Hirano, A., Wong, T.C. J. Virol. Methods (1991) [Pubmed]
  17. Domains of the measles virus N protein required for binding to P protein and self-assembly. Bankamp, B., Horikami, S.M., Thompson, P.D., Huber, M., Billeter, M., Moyer, S.A. Virology (1996) [Pubmed]
  18. Recombinant bacille Calmette-Guérin priming against measles. Fennelly, G.J., Flynn, J.L., ter Meulen, V., Liebert, U.G., Bloom, B.R. J. Infect. Dis. (1995) [Pubmed]
  19. Inefficient measles virus budding in murine L.CD46 fibroblasts. Vincent, S., Spehner, D., Manié, S., Delorme, R., Drillien, R., Gerlier, D. Virology (1999) [Pubmed]
  20. Antigenic and immunogenic investigation of B-cell epitopes in the nucleocapsid protein of peste des petits ruminants virus. Choi, K.S., Nah, J.J., Ko, Y.J., Kang, S.Y., Yoon, K.J., Jo, N.I. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
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