Gene Review:
Apln - apelin
Mus musculus
Synonyms:
6030430G11Rik, APJ endogenous ligand, Apel, Apelin
- The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments. Masri, B., Morin, N., Pedebernade, L., Knibiehler, B., Audigier, Y. J. Biol. Chem. (2006)
- Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Cox, C.M., D'Agostino, S.L., Miller, M.K., Heimark, R.L., Krieg, P.A. Dev. Biol. (2006)
- The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Ashley, E.A., Powers, J., Chen, M., Kundu, R., Finsterbach, T., Caffarelli, A., Deng, A., Eichhorn, J., Mahajan, R., Agrawal, R., Greve, J., Robbins, R., Patterson, A.J., Bernstein, D., Quertermous, T. Cardiovasc. Res. (2005)
- Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Wei, L., Hou, X., Tatemoto, K. Regul. Pept. (2005)
- G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility. Hashimoto, Y., Ishida, J., Yamamoto, R., Fujiwara, K., Asada, S., Kasuya, Y., Mochizuki, N., Fukamizu, A. Int. J. Mol. Med. (2005)
- Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Hashimoto, T., Kihara, M., Ishida, J., Imai, N., Yoshida, S., Toya, Y., Fukamizu, A., Kitamura, H., Umemura, S. Arterioscler. Thromb. Vasc. Biol. (2006)
- Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Saint-Geniez, M., Masri, B., Malecaze, F., Knibiehler, B., Audigier, Y. Mech. Dev. (2002)
- Apelin is a novel angiogenic factor in retinal endothelial cells. Kasai, A., Shintani, N., Oda, M., Kakuda, M., Hashimoto, H., Matsuda, T., Hinuma, S., Baba, A. Biochem. Biophys. Res. Commun. (2004)
- The apj receptor is expressed in pancreatic islets and its ligand, apelin, inhibits insulin secretion in mice. Sörhede Winzell, M., Magnusson, C., Ahrén, B. Regul. Pept. (2005)
- Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. Chun, H.J., Ali, Z.A., Kojima, Y., Kundu, R.K., Sheikh, A.Y., Agrawal, R., Zheng, L., Leeper, N.J., Pearl, N.E., Patterson, A.J., Anderson, J.P., Tsao, P.S., Lenardo, M.J., Ashley, E.A., Quertermous, T. J. Clin. Invest. (2008)
- Apelin expression in normal human tissues. De Falco, M., De Luca, L., Onori, N., Cavallotti, I., Artigiano, F., Esposito, V., De Luca, B., Laforgia, V., Groeger, A.M., De Luca, A. In Vivo (2002)
- Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Masri, B., Lahlou, H., Mazarguil, H., Knibiehler, B., Audigier, Y. Biochem. Biophys. Res. Commun. (2002)
- Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Higuchi, K., Masaki, T., Gotoh, K., Chiba, S., Katsuragi, I., Tanaka, K., Kakuma, T., Yoshimatsu, H. Endocrinology (2007)