Chemical Compound Review:
BIM-1 3-[1-(3- dimethylaminopropyl)indol-3- yl]-4...
Synonyms:
Tocris-0741, CHEMBL7463, BIM I, SureCN78990, BIMI0417, ...
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- Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C. Yashpal, K., Pitcher, G.M., Parent, A., Quirion, R., Coderre, T.J. J. Neurosci. (1995)
- Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24. Poinot-Chazel, C., Portier, M., Bouaboula, M., Vita, N., Pecceu, F., Gully, D., Monroe, J.G., Maffrand, J.P., Le Fur, G., Casellas, P. Biochem. J. (1996)
- Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells. Courage, C., Snowden, R., Gescher, A. Br. J. Cancer (1996)
- Anti-inflammatory properties of Gö 6850: a selective inhibitor of protein kinase C. Jacobson, P.B., Kuchera, S.L., Metz, A., Schächtele, C., Imre, K., Schrier, D.J. J. Pharmacol. Exp. Ther. (1995)
- GF 109203X, a selective inhibitor of protein kinase C, impairs retention performance in an operant task. Stemmelin, J., Mathis, C., Ungerer, A. Neuroreport (1999)
- Modulation of monocyte-endothelial cell interactions by platelet microparticles. Barry, O.P., Praticò, D., Savani, R.C., FitzGerald, G.A. J. Clin. Invest. (1998)
- PDGF induction of alpha 2 integrin gene expression is mediated by protein kinase C-zeta. Xu, J., Zutter, M.M., Santoro, S.A., Clark, R.A. J. Cell Biol. (1996)
- Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix. Slack, B.E. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors. Lee, R.K., Wurtman, R.J., Cox, A.J., Nitsch, R.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII. Ollivier, V., Bentolila, S., Chabbat, J., Hakim, J., de Prost, D. Blood (1998)
- Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers. Los, G.V., Artemenko, I.P., Hokin, L.E. Adv. Enzyme Regul. (1996)
- Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. O'Donnell, R.W., Johnson, D.K., Ziegler, L.M., DiMattina, A.J., Stone, R.I., Holland, J.A. Endothelium (2003)
- Modulation of apoptosis of proliferating and differentiating HL-60 cells by protein kinase inhibitors: suppression of PKC or PKA differently affects cell differentiation and apoptosis. Savickiene, J., Gineitis, A., Stigbrand, T. Cell Death Differ. (1999)
- Differential effects of the protein kinase C activator phorbol 12-myristate 13-acetate on calcium responses and secretion in adherent and suspended RBL-2H3 mucosal mast cells. Wolfe, P.C., Chang, E.Y., Rivera, J., Fewtrell, C. J. Biol. Chem. (1996)
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. Toullec, D., Pianetti, P., Coste, H., Bellevergue, P., Grand-Perret, T., Ajakane, M., Baudet, V., Boissin, P., Boursier, E., Loriolle, F. J. Biol. Chem. (1991)
- Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Booth, G., Stalker, T.J., Lefer, A.M., Scalia, R. Diabetes (2002)
- Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action. Levites, Y., Amit, T., Youdim, M.B., Mandel, S. J. Biol. Chem. (2002)
- Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C. Paolucci, L., Rozengurt, E. Cancer Res. (1999)
- Signaling pathways involved in IL-8-dependent activation of adhesion through Mac-1. Takami, M., Terry, V., Petruzzelli, L. J. Immunol. (2002)
- Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. Fagerström, S., Påhlman, S., Nånberg, E. J. Biol. Chem. (1998)
- Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Quagliaro, L., Piconi, L., Assaloni, R., Martinelli, L., Motz, E., Ceriello, A. Diabetes (2003)
- Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C. Habib, A., Vezza, R., Créminon, C., Maclouf, J., FitzGerald, G.A. J. Biol. Chem. (1997)
- Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. Liu, Y., Liu, Y.C., Meller, N., Giampa, L., Elly, C., Doyle, M., Altman, A. J. Immunol. (1999)
- Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion. Keely, S.J., Uribe, J.M., Barrett, K.E. J. Biol. Chem. (1998)
- Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton. Sinnett-Smith, J., Zachary, I., Valverde, A.M., Rozengurt, E. J. Biol. Chem. (1993)
- A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells. cross-talk between cyclic AMP and protein kinase c pathways. Gao, Z., Chen, T., Weber, M.J., Linden, J. J. Biol. Chem. (1999)
- Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. Avdi, N.J., Winston, B.W., Russel, M., Young, S.K., Johnson, G.L., Worthen, G.S. J. Biol. Chem. (1996)
- Endothelin-1 activates c-Jun NH2-terminal kinase in mesangial cells. Araki, S., Haneda, M., Togawa, M., Kikkawa, R. Kidney Int. (1997)
- Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively. Tóth, R., Szegezdi, E., Molnár, G., Lord, J.M., Fésüs, L., Szondy, Z. Eur. J. Immunol. (1999)
- An essential role of ERK signalling in TPA-induced reactivation of Kaposi's sarcoma-associated herpesvirus. Cohen, A., Brodie, C., Sarid, R. J. Gen. Virol. (2006)
- Characteristics of myogenic tone in the rat ophthalmic artery. Ito, I., Jarajapu, Y.P., Grant, M.B., Knot, H.J. Am. J. Physiol. Heart Circ. Physiol. (2007)
- Posttranscriptional regulation of ribonucleotide reductase R1 gene expression is linked to a protein kinase C pathway in mammalian cells. Chen, F.Y., Amara, F.M., Wright, J.A. Biochem. Cell Biol. (1994)
- Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming. Nixon, A.B., Seeds, M.C., Bass, D.A., Smitherman, P.K., O'Flaherty, J.T., Daniel, L.W., Wykle, R.L. Biochim. Biophys. Acta (1997)