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HOXC4  -  homeobox C4

Homo sapiens

Synonyms: HOX3, HOX3E, Homeobox protein CP19, Homeobox protein Hox-3E, Homeobox protein Hox-C4, ...
 
 
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Disease relevance of HOXC4

 

High impact information on HOXC4

 

Biological context of HOXC4

 

Anatomical context of HOXC4

  • The early expression and the nucleolar localization suggest an involvement of HOXC4 in the regulation of genes controlling lymphocyte activation and/or proliferation [11].
  • These results suggest that HOXC4 is expressed mainly in differentiated keratinocytes [3].
  • In earliest CD34+/CD38low and high cell fractions of bone marrow only HOXC4 and in megakaryocytic cells both HOXC4 and HOXC6 were found [4].
  • Overexpression of HOXC4 in human CD34(+) cells was obtained by retroviral gene transfer; its effect on clonogenic (CFU-GM, BFU-E, and CFU-GEMM) and early progenitors (LTC-IC) was evaluated [5].
 

Regulatory relationships of HOXC4

  • CONCLUSION: We demonstrate that HOXC4 is expressed in CD34(+) cells and that its overexpression induces an in vitro expansion of committed as well as very early hematopoietic progenitors [5].
 

Other interactions of HOXC4

  • Recently, we reported a largely similar expression pattern of HOXC4 and HOXC6 in normal and neoplastic cells of the lymphoid lineage [1].
  • Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation [3].
  • A good correlation between the distribution pattern of HOXC4 and cytokeratin 10 in the lesions examined was found [3].
  • However, recent studies demonstrated, by RT-PCR, that the HOXC4 gene is also actively transcribed in the most undifferentiated hematopoietic cells (CD34(+)38(low)) and in more mature myeloid and erythroid progenitors [5].
 

Analytical, diagnostic and therapeutic context of HOXC4

  • Northern blot analysis on polyA+ RNA from activated PBLs or Raji cells showed the presence of two different HOXC4 transcripts of 2.8 and 1.9 kb [11].

References

  1. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. Bijl, J.J., Rieger, E., van Oostveen, J.W., Walboomers, J.M., Kreike, M., Willemze, R., Meijer, C.J. Am. J. Pathol. (1997) [Pubmed]
  2. HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas. Bijl, J.J., van Oostveen, J.W., Walboomers, J.M., Horstman, A., van den Brule, A.J., Willemze, R., Meijer, C.J. Blood (1997) [Pubmed]
  3. Expression of the homeobox gene HOXC4 in keratinocytes of normal skin and epithelial skin tumors is correlated with differentiation. Rieger, E., Bijl, J.J., van Oostveen, J.W., Soyer, H.P., Oudejans, C.B., Jiwa, N.M., Walboomers, J.M., Meijer, C.J. J. Invest. Dermatol. (1994) [Pubmed]
  4. Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells. Bijl, J.J., van Oostveen, J.W., Walboomers, J.M., Brink, A.T., Vos, W., Ossenkoppele, G.J., Meijer, C.J. Leukemia (1998) [Pubmed]
  5. The retroviral transduction of HOXC4 into human CD34(+) cells induces an in vitro expansion of clonogenic and early progenitors. Daga, A., Podesta, M., Capra, M.C., Piaggio, G., Frassoni, F., Corte, G. Exp. Hematol. (2000) [Pubmed]
  6. Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue. Bijl, J., van Oostveen, J.W., Kreike, M., Rieger, E., van der Raaij-Helmer, L.M., Walboomers, J.M., Corte, G., Boncinelli, E., van den Brule, A.J., Meijer, C.J. Blood (1996) [Pubmed]
  7. The human HOX gene family. Acampora, D., D'Esposito, M., Faiella, A., Pannese, M., Migliaccio, E., Morelli, F., Stornaiuolo, A., Nigro, V., Simeone, A., Boncinelli, E. Nucleic Acids Res. (1989) [Pubmed]
  8. HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development. Stelnicki, E.J., Kömüves, L.G., Kwong, A.O., Holmes, D., Klein, P., Rozenfeld, S., Lawrence, H.J., Adzick, N.S., Harrison, M., Largman, C. J. Invest. Dermatol. (1998) [Pubmed]
  9. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. Gong, L.G., Qiu, G.R., Jiang, H., Xu, X.Y., Zhu, H.Y., Sun, K.L. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2005) [Pubmed]
  10. Unusual gene order and organization of the sea urchin hox cluster. Cameron, R.A., Rowen, L., Nesbitt, R., Bloom, S., Rast, J.P., Berney, K., Arenas-Mena, C., Martinez, P., Lucas, S., Richardson, P.M., Davidson, E.H., Peterson, K.J., Hood, L. J. exp. zool. B. Mol. Dev. Evol. (2006) [Pubmed]
  11. Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. Meazza, R., Faiella, A., Corsetti, M.T., Airoldi, I., Ferrini, S., Boncinelli, E., Corte, G. Blood (1995) [Pubmed]
 
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