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Gene Review

Pkd2l1  -  polycystic kidney disease 2-like 1

Mus musculus

Synonyms: B830002B15, BC046386, PCL, PKD2L, Pkdl, ...
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Disease relevance of Pkd2l1


High impact information on Pkd2l1


Biological context of Pkd2l1


Anatomical context of Pkd2l1


Associations of Pkd2l1 with chemical compounds

  • Fluorescently labeled PEO(45)-b-PCL(23) block copolymer was prepared by conjugating a tetramethylrhodamine molecule to the end of the hydrophobic PCL block [8].
  • In vitro and in vivo scaffold degradation rate could be differentiated using a fast degrading polymer (e.g., poly D, L-lactic-glycolic acid co-polymer, PLGA, 50:50) and a slow degrading polymer (e.g., poly epsilon-caprolactone, PCL) [9].
  • Spleen cells from C3H/HeN mice primed for CS responses either by the topical application of picryl chloride or by the adoptive transfer of PCL immune cells show little or no cytolytic activity in vitro against TNP-coupled target cells [10].

Analytical, diagnostic and therapeutic context of Pkd2l1

  • The immune response to diphtheria toxoid loaded PCL-TPGS microspheres after nasal administration was shown to be higher than that achieved using PCL microspheres alone [11].
  • However, both PCL sensitization and adoptive transfer, when combined with the injection of TNP-substituted syngeneic spleen cells, induce significant cytolytic activity against TNP-haptenated BW5147 target cells in vitro [10].


  1. Interaction of antigen-specific T cell factors with unique "receptors" on the surface of mast cells: demonstration in vitro by an indirect rosetting technique. Kops, S.K., Ratzlaff, R.E., Meade, R., Iverson, G.M., Askenase, P.W. J. Immunol. (1986) [Pubmed]
  2. Taxol-loaded block copolymer nanospheres composed of methoxy poly(ethylene glycol) and poly(epsilon-caprolactone) as novel anticancer drug carriers. Kim, S.Y., Lee, Y.M. Biomaterials (2001) [Pubmed]
  3. More than colocalizing with polycystin-1, polycystin-L is in the centrosome. Bui-Xuan, E.F., Li, Q., Chen, X.Z., Boucher, C.A., Sandford, R., Zhou, J., Basora, N. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  4. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. LopezJimenez, N.D., Cavenagh, M.M., Sainz, E., Cruz-Ithier, M.A., Battey, J.F., Sullivan, S.L. J. Neurochem. (2006) [Pubmed]
  5. Osteoblastic phenotype expression of MC3T3-E1 cells cultured on polymer surfaces. Calvert, J.W., Chua, W.C., Gharibjanian, N.A., Dhar, S., Evans, G.R. Plast. Reconstr. Surg. (2005) [Pubmed]
  6. Composite cell support membranes based on collagen and polycaprolactone for tissue engineering of skin. Dai, N.T., Williamson, M.R., Khammo, N., Adams, E.F., Coombes, A.G. Biomaterials (2004) [Pubmed]
  7. Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique. Vaz, C.M., van Tuijl, S., Bouten, C.V., Baaijens, F.P. Acta biomaterialia. (2005) [Pubmed]
  8. Cellular internalization of poly(ethylene oxide)-b-poly(epsilon-caprolactone) diblock copolymer micelles. Luo, L., Tam, J., Maysinger, D., Eisenberg, A. Bioconjug. Chem. (2002) [Pubmed]
  9. The effect of scaffold degradation rate on three-dimensional cell growth and angiogenesis. Sung, H.J., Meredith, C., Johnson, C., Galis, Z.S. Biomaterials (2004) [Pubmed]
  10. Generation of anti-hapten T cell cytotoxicity in vivo. Relationship to contact sensitivity and the role of contrasuppression. Ptak, W., Friedman, A.M., Flood, P.M. Arch. Immunol. Ther. Exp. (Warsz.) (1994) [Pubmed]
  11. Effect of vitamin E TPGS on immune response to nasally delivered diphtheria toxoid loaded poly(caprolactone) microparticles. Somavarapu, S., Pandit, S., Gradassi, G., Bandera, M., Ravichandran, E., Alpar, O.H. International journal of pharmaceutics. (2005) [Pubmed]
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