Gene Review:
Fa2h - fatty acid 2-hydroxylase
Mus musculus
Synonyms:
FAAH, Faah, Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, Faxdc1, ...
- Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. Liu, J., Batkai, S., Pacher, P., Harvey-White, J., Wagner, J.A., Cravatt, B.F., Gao, B., Kunos, G. J. Biol. Chem. (2003)
- Assessment of anandamide's pharmacological effects in mice deficient of both fatty acid amide hydrolase and cannabinoid CB(1) receptors. Wise, L.E., Shelton, C.C., Cravatt, B.F., Martin, B.R., Lichtman, A.H. Eur. J. Pharmacol. (2007)
- Structure and function of fatty acid amide hydrolase. McKinney, M.K., Cravatt, B.F. Annu. Rev. Biochem. (2005)
- Functional disassociation of the central and peripheral fatty acid amide signaling systems. Cravatt, B.F., Saghatelian, A., Hawkins, E.G., Clement, A.B., Bracey, M.H., Lichtman, A.H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Alexander, J.P., Cravatt, B.F. Chem. Biol. (2005)
- The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide. Di Marzo, V., Bisogno, T., Sugiura, T., Melck, D., De Petrocellis, L. Biochem. J. (1998)
- FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. Alderson, N.L., Maldonado, E.N., Kern, M.J., Bhat, N.R., Hama, H. J. Lipid Res. (2006)
- Expression and regulation of the fatty acid amide hydrolase gene in the rat uterus during the estrous cycle and peri-implantation period. Xiao, A.Z., Zhao, Y.G., Duan, E.K. Mol. Hum. Reprod. (2002)
- A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Saghatelian, A., McKinney, M.K., Bandell, M., Patapoutian, A., Cravatt, B.F. Biochemistry (2006)
- Anandamide activity and degradation are regulated by early postnatal aging and follicle-stimulating hormone in mouse Sertoli cells. Maccarrone, M., Cecconi, S., Rossi, G., Battista, N., Pauselli, R., Finazzi-Agrò, A. Endocrinology (2003)
- Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. Weber, A., Ni, J., Ling, K.H., Acheampong, A., Tang-Liu, D.D., Burk, R., Cravatt, B.F., Woodward, D. J. Lipid Res. (2004)
- Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. Holt, S., Comelli, F., Costa, B., Fowler, C.J. Br. J. Pharmacol. (2005)
- Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids. McKinney, M.K., Cravatt, B.F. Biochemistry (2006)
- Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice. Basavarajappa, B.S., Yalamanchili, R., Cravatt, B.F., Cooper, T.B., Hungund, B.L. Neuropharmacology (2006)
- The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Patel, S., Wohlfeil, E.R., Rademacher, D.J., Carrier, E.J., Perry, L.J., Kundu, A., Falck, J.R., Nithipatikom, K., Campbell, W.B., Hillard, C.J. Br. J. Pharmacol. (2003)