The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

ENPP7  -  ectonucleotide pyrophosphatase/phosphodies...

Homo sapiens

Synonyms: ALK-SMase, Alk-SMase, Alkaline sphingomyelin phosphodiesterase, E-NPP 7, Ectonucleotide pyrophosphatase/phosphodiesterase family member 7, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of ENPP7

 

High impact information on ENPP7

 

Biological context of ENPP7

 

Anatomical context of ENPP7

 

Associations of ENPP7 with chemical compounds

  • Treating alk-SMase cDNA-transfected COS-7 cells with tunicamycin rendered the expressed enzyme completely inactive [7].
  • Intestinal alkaline sphingomyelinase (alk-SMase) digests sphingomyelin and the process may influence colonic tumorigenesis and cholesterol absorption [8].
  • Alkaline sphingomyelinase (alk-SMase) is a new member of the NPP (nucleotide pyrophosphatase/phosphodiesterase) family that hydrolyses SM (sphingomyelin) to generate ceramide in the intestinal tract [11].
  • Feeding rats with 0.3% (w/w) taurocholate for four days decreased peak activity of intestinal alkaline sphingomyelinase by 39% and total activity in the intestine by 20% and increased the output of the enzyme in the feces [12].
 

Analytical, diagnostic and therapeutic context of ENPP7

  • Northern blotting of human intestinal tissues found high levels of alk-SMase mRNA in the intestine and liver [5].
  • Total RNA was isolated and the cDNA of alk-SMase was amplified by RT-PCR [1].
  • To confirm the cloned protein is the real form of alk-SMase, native alk-SMase was purified from rat intestine and subjected to proteolytic digestion followed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry and electrospray ionization (ESI) tandem mass spectrometry [8].
  • In this work, we compared the effects of ursodeoxycholate and other bile salts on the levels of rat intestinal alkaline sphingomyelinase both in the intestinal loops and after oral administration [12].

References

  1. Identification of one exon deletion of intestinal alkaline sphingomyelinase in colon cancer HT-29 cells and a differentiation-related expression of the wild-type enzyme in Caco-2 cells. Wu, J., Cheng, Y., Nilsson, A., Duan, R.D. Carcinogenesis (2004) [Pubmed]
  2. Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity. Sjöqvist, U., Hertervig, E., Nilsson, A., Duan, R.D., Ost, A., Tribukait, B., Löfberg, R. Inflamm. Bowel Dis. (2002) [Pubmed]
  3. Human meconium contains significant amounts of alkaline sphingomyelinase, neutral ceramidase, and sphingolipid metabolites. Duan, R.D., Cheng, Y., J??nsson, B.A., Ohlsson, L., Herbst, A., Hellstr??m-Westas, L., Nilsson, A. Pediatr. Res. (2007) [Pubmed]
  4. Alkaline sphingomyelinase: An old enzyme with novel implications. Duan, R.D. Biochim. Biophys. Acta (2006) [Pubmed]
  5. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. Duan, R.D., Bergman, T., Xu, N., Wu, J., Cheng, Y., Duan, J., Nelander, S., Palmberg, C., Nilsson, A. J. Biol. Chem. (2003) [Pubmed]
  6. Absorption and lipoprotein transport of sphingomyelin. Nilsson, A., Duan, R.D. J. Lipid Res. (2006) [Pubmed]
  7. Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis. Wu, J., Hansen, G.H., Nilsson, A., Duan, R.D. Biochem. J. (2005) [Pubmed]
  8. Cloning of alkaline sphingomyelinase from rat intestinal mucosa and adjusting of the hypothetical protein XP_221184 in GenBank. Wu, J., Cheng, Y., Palmberg, C., Bergman, T., Nilsson, A., Duan, R.D. Biochim. Biophys. Acta (2005) [Pubmed]
  9. Detection of alkaline sphingomyelinase activity in human stool: proposed role as a new diagnostic and prognostic marker of colorectal cancer. Di Marzio, L., Di Leo, A., Cinque, B., Fanini, D., Agnifili, A., Berloco, P., Linsalata, M., Lorusso, D., Barone, M., De Simone, C., Cifone, M.G. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  10. Purification, localization, and expression of human intestinal alkaline sphingomyelinase. Duan, R.D., Cheng, Y., Hansen, G., Hertervig, E., Liu, J.J., Syk, I., Sjostrom, H., Nilsson, A. J. Lipid Res. (2003) [Pubmed]
  11. Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Wu, J., Nilsson, A., Jönsson, B.A., Stenstad, H., Agace, W., Cheng, Y., Duan, R.D. Biochem. J. (2006) [Pubmed]
  12. Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis. Duan, R.D., Cheng, Y., Tauschel, H.D., Nilsson, A. Dig. Dis. Sci. (1998) [Pubmed]
 
WikiGenes - Universities