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Gene Review

STC1  -  stanniocalcin 1

Homo sapiens

Synonyms: STC, STC-1, Stanniocalcin-1
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Disease relevance of STC1

  • The related gene, STC1, was also examined and shown to be associated with ER status in breast carcinomas (Fisher's exact test, P < 0.05) [1].
  • We conclude that these human fibrosarcoma cells express both STC1 and STC2 as secreted phosphoproteins in vivo, with STC2 being phosphorylated by an ecto-CK2-like enzyme [2].
  • STC1 is present in breast ductal epithelium, and its expression is induced by BRCA1, a tumor suppressor gene that has an important role in breast and ovarian cancer [3].
  • In contrast, expression of another homologue, STC1, is only upregulated by hypoxia independent of PERK or ATF4 expression [4].
  • The data further supports the notion that STC1 plays a role in breast cancer and that it may prove to be a novel diagnostic and prognostic marker, and potential therapeutic target [5].

Psychiatry related information on STC1

  • Moreover, even wild-type pups exhibited a growth retardation phenotype when nursed by a transgenic foster mother, and this implies that hSTC overexpression deleteriously affects maternal behavior and/or lactation [6].

High impact information on STC1


Chemical compound and disease context of STC1

  • A novel C1-using denitrifier alcaligenes sp. STC1 and its genes for copper-containing nitrite reductase and azurin [9].
  • Given that mobilization and influx of calcium is considered a main neurotoxic mechanism following ischemia, our results suggest that the altered expression of STC contributes to the protection of cerebral neurons against hypoxic/ischemic damage [8].
  • In human insulinoma (CM) cells, in human pancreatic carcinoid (BON) cells and in NE tumour cells of the gut (STC-1), gefitinib induced a time- and dose-dependent growth inhibition by almost 100% [10].
  • The aim of this study was to evaluate a modified method applying 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride (STC) to the Clinical and Laboratory Standards Institute (CLSI) guideline for susceptibility testing of Mycobacterium tuberculosis [11].

Biological context of STC1


Anatomical context of STC1


Associations of STC1 with chemical compounds


Regulatory relationships of STC1


Other interactions of STC1

  • STC1 plays a role in calcium and phosphate homoeostasis, while the role of STC2 is unknown [2].
  • Following incubation of HT1080 cells with (32)P, labelled STC1 and STC2 were found to be secreted into the medium [2].
  • Collectively, the present findings provide the first evidence of HIF-1 regulation of STC1 expression in human cancer cells [16].
  • In contrast, HIF-targets Pgf (placental growth factor) and Egln3 were strongly affected by the CH1 mutation, while Stc1 (stanniocalcin-1) and Slc2a1 (glucose-transporter-1) were moderately affected [22].
  • The inhibitory effect of STC1 was accompanied by a pronounced suppression of the CYP11A transcripts and the FSH induction of functional LH receptors [19].

Analytical, diagnostic and therapeutic context of STC1


  1. Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer. Bouras, T., Southey, M.C., Chang, A.C., Reddel, R.R., Willhite, D., Glynne, R., Henderson, M.A., Armes, J.E., Venter, D.J. Cancer Res. (2002) [Pubmed]
  2. Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. Jellinek, D.A., Chang, A.C., Larsen, M.R., Wang, X., Robinson, P.J., Reddel, R.R. Biochem. J. (2000) [Pubmed]
  3. Mammalian stanniocalcins and cancer. Chang, A.C., Jellinek, D.A., Reddel, R.R. Endocr. Relat. Cancer (2003) [Pubmed]
  4. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Ito, D., Walker, J.R., Thompson, C.S., Moroz, I., Lin, W., Veselits, M.L., Hakim, A.M., Fienberg, A.A., Thinakaran, G. Mol. Cell. Biol. (2004) [Pubmed]
  5. Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. McCudden, C.R., Majewski, A., Chakrabarti, S., Wagner, G.F. Mol. Cell. Endocrinol. (2004) [Pubmed]
  6. Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. Varghese, R., Gagliardi, A.D., Bialek, P.E., Yee, S.P., Wagner, G.F., Dimattia, G.E. Endocrinology (2002) [Pubmed]
  7. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Welcsh, P.L., Lee, M.K., Gonzalez-Hernandez, R.M., Black, D.J., Mahadevappa, M., Swisher, E.M., Warrington, J.A., King, M.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Stanniocalcin: A molecular guard of neurons during cerebral ischemia. Zhang, K., Lindsberg, P.J., Tatlisumak, T., Kaste, M., Olsen, H.S., Andersson, L.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  9. A novel C1-using denitrifier alcaligenes sp. STC1 and its genes for copper-containing nitrite reductase and azurin. Ozeki, S., Baba, I., Takaya, N., Shoun, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
  10. A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839). Höpfner, M., Sutter, A.P., Gerst, B., Zeitz, M., Scherübl, H. Br. J. Cancer (2003) [Pubmed]
  11. Evaluation of a modified antimycobacterial susceptibility test using Middlebrook 7H10 agar containing 2,3-diphenyl-5-thienyl-(2)-tetrazolium chloride. Lee, S., Kong, D.H., Yun, S.H., Lee, K.R., Lee, K.P., Franzblau, S.G., Lee, E.Y., Chang, C.L. J. Microbiol. Methods (2006) [Pubmed]
  12. Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Luo, C.W., Pisarska, M.D., Hsueh, A.J. Endocrinology (2005) [Pubmed]
  13. Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. Gagliardi, A.D., Kuo, E.Y., Raulic, S., Wagner, G.F., DiMattia, G.E. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
  14. Molecular cloning and characterization of stanniocalcin-related protein. DiMattia, G.E., Varghese, R., Wagner, G.F. Mol. Cell. Endocrinol. (1998) [Pubmed]
  15. Avian stanniocalcin-2 is expressed in developing striated muscle and joints. Mittapalli, V.R., Pr??ls, F., Huang, R., Christ, B., Scaal, M. Anat. Embryol. (2006) [Pubmed]
  16. Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. Yeung, H.Y., Lai, K.P., Chan, H.Y., Mak, N.K., Wagner, G.F., Wong, C.K. Endocrinology (2005) [Pubmed]
  17. Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. Xiao, L.J., Yuan, J.X., Song, X.X., Li, Y.C., Hu, Z.Y., Liu, Y.X. Reproduction (2006) [Pubmed]
  18. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Chang, A.C., Reddel, R.R. Mol. Cell. Endocrinol. (1998) [Pubmed]
  19. Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Luo, C.W., Kawamura, K., Klein, C., Hsueh, A.J. Mol. Endocrinol. (2004) [Pubmed]
  20. Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line. Abello, J., Ye, F., Bosshard, A., Bernard, C., Cuber, J.C., Chayvialle, J.A. Endocrinology (1994) [Pubmed]
  21. Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes. Chakraborty, A., Brooks, H., Zhang, P., Smith, W., McReynolds, M.R., Hoying, J.B., Bick, R., Truong, L., Poindexter, B., Lan, H., Elbjeirami, W., Sheikh-Hamad, D. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  22. Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Kasper, L.H., Brindle, P.K. Cell Cycle (2006) [Pubmed]
  23. Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. Wagner, G.F., Guiraudon, C.C., Milliken, C., Copp, D.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  24. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. Wu, S., Yoshiko, Y., De Luca, F. J. Biol. Chem. (2006) [Pubmed]
  25. Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. Chang, A.C., Jeffrey, K.J., Tokutake, Y., Shimamoto, A., Neumann, A.A., Dunham, M.A., Cha, J., Sugawara, M., Furuichi, Y., Reddel, R.R. Genomics (1998) [Pubmed]
  26. Molecular cloning of a second human stanniocalcin homologue (STC2). Ishibashi, K., Miyamoto, K., Taketani, Y., Morita, K., Takeda, E., Sasaki, S., Imai, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  27. Stanniocalcin-1 as a novel marker to detect minimal residual disease of human leukemia. Tohmiya, Y., Koide, Y., Fujimaki, S., Harigae, H., Funato, T., Kaku, M., Ishii, T., Munakata, Y., Kameoka, J., Sasaki, T. Tohoku J. Exp. Med. (2004) [Pubmed]
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