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Gene Review

Z600  -  CG17962 gene product from transcript...

Drosophila melanogaster

Synonyms: 3.2, CG17962, DMZ60MEX, Dmel\CG17962, Frs, ...
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Disease relevance of Z600

  • We analysed 165 sporadic uterine fibroids to define a small 3.2 megabase (Mb) commonly deleted region on 7q22.3-q31.1, flanked by clones AC005070 and AC007567 [1].
  • In a search through 35 kb of Dfd sequences for additional transcriptional control elements, we have identified a 3.2 kb DNA fragment containing an enhancer that mimics the expression of Dfd in the subesophageal ganglion of the embryonic central nervous system [2].

High impact information on Z600

  • We have identified two genes, frühstart and tribbles, that are required for this ventral inhibition. tribbles encodes a kinase-related protein whose RNA, however, is also present outside of the ventral region [3].
  • The 3.2 kb genomic DNA fragment hybridizes to a 1.8 kb polyadenylated transcript which accumulates maximally at 2-4 hr of embryonic development [4].
  • Each is restricted to either a 3.2- or a 4.3-kb size class generated by alternative polyadenylation [5].
  • As revealed by RNA blot-hybridization analysis, two mRNA species of 2.3 and 3.2 kb are detected in the central nervous system of Lymnaea [6].
  • At 18 degrees C and 24 degrees C, separated sister chromatids moved poleward at average rates (3.6 and 6.6 microm/min, respectively) slightly greater than the mean rates of poleward flux (3.2 and 5.2 microm/min, respectively) [7].

Biological context of Z600

  • We have used several approaches to study the spatial and temporal expression of z600 during embryogenesis [8].
  • The Drosophila z600 gene is a member of an overlapping gene cluster located in the 71CD interval of chromosome 3 [8].
  • An analysis of germ line transformants harboring a z600-lacZ gene fusion demonstrates that a 276-bp DNA region contains the sequences responsible for dorsal activation, but not ventral repression, of z600 gene expression during early embryogenesis [8].
  • Furthermore, the expression of frs is delayed in haploid embryos and requires activity of the maternal checkpoint gene grapes [9].
  • Here we isolate the zygotic gene frühstart of Drosophila and show that it is involved in pausing the cleavage cell cycle. frs is expressed immediately after the last cleavage division [9].

Anatomical context of Z600

  • A specific mRNA of 3.2 kilobases was detected in low abundance in many cell types and found highly expressed in testis [10].
  • The 3.2 kb mRNA encoding the 98 kDa protein isoform is selectively localised in the oocyte up to stage 9 [11].
  • The Drosophila melanogaster z600 gene encodes a chromatin-associated protein synthesized in the syncytial blastoderm [12].
  • We show that the export of the 3.2 kb mRNA from the nurse cell nuclei requires a functional otu protein [11].
  • Quantitative real-time polymerase chain reaction studies verified that the highest levels of Sp1 transcript expression of 4.1, 3.7, and 3.2 kb occur in the primary spermatocytes [13].

Associations of Z600 with chemical compounds


Other interactions of Z600

  • Transcripts most likely start in front of or within the 3.2 Mb region of YLII-related sequences, pass through subsequent blocks of 1.2 and 0.3 Mb of YLI- and rally-related sequences, respectively, and cease within the region of a smaller block of YLI-related repeats [15].

Analytical, diagnostic and therapeutic context of Z600

  • Two transcripts, 3.2 and 5kb, were detected, in northern blot analysis, with different expression patterns in the surveyed tissues when different cDNAs were used [16].
  • We localized the z600 protein in whole-amount embryos by indirect immunofluorescence [12].


  1. 7q deletion mapping and expression profiling in uterine fibroids. Vanharanta, S., Wortham, N.C., Laiho, P., Sjöberg, J., Aittomäki, K., Arola, J., Tomlinson, I.P., Karhu, A., Arango, D., Aaltonen, L.A. Oncogene (2005) [Pubmed]
  2. Deformed expression in the Drosophila central nervous system is controlled by an autoactivated intronic enhancer. Lou, L., Bergson, C., McGinnis, W. Nucleic Acids Res. (1995) [Pubmed]
  3. A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila. Grosshans, J., Wieschaus, E. Cell (2000) [Pubmed]
  4. A molecular analysis of fushi tarazu, a gene in Drosophila melanogaster that encodes a product affecting embryonic segment number and cell fate. Weiner, A.J., Scott, M.P., Kaufman, T.C. Cell (1984) [Pubmed]
  5. Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Kornfeld, K., Saint, R.B., Beachy, P.A., Harte, P.J., Peattie, D.A., Hogness, D.S. Genes Dev. (1989) [Pubmed]
  6. Serotonin receptor cDNA cloned from Lymnaea stagnalis. Sugamori, K.S., Sunahara, R.K., Guan, H.C., Bulloch, A.G., Tensen, C.P., Seeman, P., Niznik, H.B., Van Tol, H.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  7. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Maddox, P., Desai, A., Oegema, K., Mitchison, T.J., Salmon, E.D. Curr. Biol. (2002) [Pubmed]
  8. Dorsal expression of the Drosophila z600 gene during early embryogenesis. Schulz, R.A., Miksch, J.L. Dev. Biol. (1989) [Pubmed]
  9. Control of cleavage cycles in Drosophila embryos by frühstart. Grosshans, J., Müller, H.A., Wieschaus, E. Dev. Cell (2003) [Pubmed]
  10. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. Touré, A., Dorseuil, O., Morin, L., Timmons, P., Jégou, B., Reibel, L., Gacon, G. J. Biol. Chem. (1998) [Pubmed]
  11. Two otu transcripts are selectively localised in Drosophila oogenesis by a mechanism that requires a function of the otu protein. Tirronen, M., Lahti, V.P., Heino, T.I., Roos, C. Mech. Dev. (1995) [Pubmed]
  12. The Drosophila melanogaster z600 gene encodes a chromatin-associated protein synthesized in the syncytial blastoderm. Galewsky, S., Xie, X.L., Schulz, R.A. Gene (1990) [Pubmed]
  13. Identification, characterization, and functional analysis of sp1 transcript variants expressed in germ cells during mouse spermatogenesis. Thomas, K., Sung, D.Y., Yang, J., Johnson, K., Thompson, W., Millette, C., McCarrey, J., Breitberg, A., Gibbs, R., Walker, W. Biol. Reprod. (2005) [Pubmed]
  14. Cytogenetic toxicity and no-effect limit dose of pesticides. Kumar, D., Khan, P.K., Sinha, S.P. Food Chem. Toxicol. (1995) [Pubmed]
  15. Strukturdifferenzierungen in Y-chromosom von Drosophila hydei: the unique morphology of the Y chromosomal lampbrush loops Threads results from 'coaxial shells' formed by different satellite-specific subregions within megabase-sized transcripts. Kurek, R., Trapitz, P., Bünemann, H. Chromosome Res. (1996) [Pubmed]
  16. Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome. Pizzuti, A., Novelli, G., Mari, A., Ratti, A., Colosimo, A., Amati, F., Penso, D., Sangiuolo, F., Calabrese, G., Palka, G., Silani, V., Gennarelli, M., Mingarelli, R., Scarlato, G., Scambler, P., Dallapiccola, B. Am. J. Hum. Genet. (1996) [Pubmed]
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