Gene Review:
CYP4F3 - cytochrome P450, family 4, subfamily F,...
Homo sapiens
Synonyms:
20-HETE synthase, 20-hydroxyeicosatetraenoic acid synthase, CPF3, CYP4F, CYPIVF3, ...
Christmas,
Carlesso,
Shang,
Cheng,
Weber,
Preffer,
Scadden,
Soberman,
Kikuta,
Miyauchi,
Kusunose,
Kusunose,
Hashizume,
Imaoka,
Mise,
Terauchi,
Fujii,
Miyazaki,
Kamataki,
Funae,
Kikuta,
Yamashita,
Kashiwagi,
Tani,
Okada,
Nakata,
Hashizume,
Imaoka,
Hiroi,
Terauchi,
Fujii,
Miyazaki,
Kamataki,
Funae,
Christmas,
Jones,
Patten,
Rock,
Zheng,
Cheng,
Weber,
Carlesso,
Scadden,
Rettie,
Soberman,
Bylund,
Finnström,
Oliw,
- Cytochrome P-450 4F18 is the leukotriene B4 omega-1/omega-2 hydroxylase in mouse polymorphonuclear leukocytes: identification as the functional orthologue of human polymorphonuclear leukocyte CYP4F3A in the down-regulation of responses to LTB4. Christmas, P., Tolentino, K., Primo, V., Berry, K.Z., Murphy, R.C., Chen, M., Lee, D.M., Soberman, R.J. J. Biol. Chem. (2006)
- Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. Christmas, P., Carlesso, N., Shang, H., Cheng, S.M., Weber, B.M., Preffer, F.I., Scadden, D.T., Soberman, R.J. J. Biol. Chem. (2003)
- Alternative splicing determines the function of CYP4F3 by switching substrate specificity. Christmas, P., Jones, J.P., Patten, C.J., Rock, D.A., Zheng, Y., Cheng, S.M., Weber, B.M., Carlesso, N., Scadden, D.T., Rettie, A.E., Soberman, R.J. J. Biol. Chem. (2001)
- Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization. Kikuta, Y., Kato, M., Yamashita, Y., Miyauchi, Y., Tanaka, K., Kamada, N., Kusunose, M. DNA Cell Biol. (1998)
- Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene. Kikuta, Y., Miyauchi, Y., Kusunose, E., Kusunose, M. DNA Cell Biol. (1999)
- Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells. Kikuta, Y., Yamashita, Y., Kashiwagi, S., Tani, K., Okada, K., Nakata, K. Biochim. Biophys. Acta (2004)
- cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Hashizume, T., Imaoka, S., Hiroi, T., Terauchi, Y., Fujii, T., Miyazaki, H., Kamataki, T., Funae, Y. Biochem. Biophys. Res. Commun. (2001)
- Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles. Bylund, J., Finnström, N., Oliw, E.H. Biochem. Biophys. Res. Commun. (1999)
- Prostaglandin and leukotriene omega-hydroxylases. Kikuta, Y., Kusunose, E., Kusunose, M. Prostaglandins Other Lipid Mediat. (2002)
- Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides. Le Quéré, V., Plée-Gautier, E., Potin, P., Madec, S., Salaün, J.P. J. Lipid Res. (2004)
- Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. Hashizume, T., Imaoka, S., Mise, M., Terauchi, Y., Fujii, T., Miyazaki, H., Kamataki, T., Funae, Y. J. Pharmacol. Exp. Ther. (2002)
- CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease. Xu, F., Ng, V.Y., Kroetz, D.L., de Montellano, P.R. J. Pharmacol. Exp. Ther. (2006)
- Covalent linkage of prosthetic heme to CYP4 family P450 enzymes. Henne, K.R., Kunze, K.L., Zheng, Y.M., Christmas, P., Soberman, R.J., Rettie, A.E. Biochemistry (2001)
- Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids. Kalsotra, A., Turman, C.M., Kikuta, Y., Strobel, H.W. Toxicol. Appl. Pharmacol. (2004)
- Sexual dimorphism and tissue specificity in the expression of CYP4F forms in Sprague Dawley rats. Kalsotra, A., Anakk, S., Boehme, C.L., Strobel, H.W. Drug Metab. Dispos. (2002)